Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lianhui Sun"'
Lactylated Apolipoprotein C‐II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis
Autor:
Jian Chen, Deping Zhao, Yupeng Wang, Ming Liu, Yuan Zhang, Tingting Feng, Chao Xiao, Huan Song, Rui Miao, Li Xu, Hongwei Chen, Xiaoying Qiu, Yi Xu, Jingxuan Xu, Zelin Cui, Wei Wang, Yanchun Quan, Yifeng Zhu, Chen Huang, Song Guo Zheng, Jian‐yuan Zhao, Ting Zhu, Lianhui Sun, Guangjian Fan
Publikováno v:
Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)
Abstract Mortality rates due to lung cancer are high worldwide. Although PD‐1 and PD‐L1 immune checkpoint inhibitors boost the survival of patients with non‐small‐cell lung cancer (NSCLC), resistance often arises. The Warburg Effect, which ca
Externí odkaz:
https://doaj.org/article/88d173ca899746b58f577c26b1255723
Autor:
Lianhui Sun, Yuan Zhang, Boyu Yang, Sijun Sun, Pengshan Zhang, Zai Luo, Tingting Feng, Zelin Cui, Ting Zhu, Yuming Li, Zhengjun Qiu, Guangjian Fan, Chen Huang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Cuproptosis, caused by excessively high copper concentrations, is urgently exploited as a potential cancer therapeutic. However, the mechanisms underlying the initiation, propagation, and ultimate execution of cuproptosis in tumors remain un
Externí odkaz:
https://doaj.org/article/5db9a4a545be44c3b1fa6184874118e4
Autor:
Lianhui Sun, Xing Wang, Lixiao Chen, Zheng Gao, Songhui Xu, Chen Hu, Guangjian Fan, Baoxin Wang, Tingting Feng, Wang Wang, Xinjiang Ying
Publikováno v:
Cell Insight, Vol 2, Iss 6, Pp 100127- (2023)
Hypopharyngeal squamous cell carcinoma (HSCC) is a highly aggressive malignancy that constitutes approximately 95% of all hypopharyngeal carcinomas, and it carries a poor prognosis. The primary factor influencing the efficacy of anti-cancer drugs for
Externí odkaz:
https://doaj.org/article/5920ca4793a240f49c53a728285cb3db
Autor:
Guangjian Fan, Lianhui Sun, Ling Meng, Chen Hu, Xing Wang, Zhan Shi, Congli Hu, Yang Han, Qingqing Yang, Liu Cao, Xiaohong Zhang, Yan Zhang, Xianmin Song, Shujie Xia, Baokun He, Shengping Zhang, Chuangui Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Centrosome clustering is a promising therapeutic target in cancer but how it is regulated remains unclear. Here, the authors show that in response to DNA damage, ATM/ATR stabilize the centrosome clustering regulator KIFC1 leading to increased cluster
Externí odkaz:
https://doaj.org/article/3daed719cc8f4fb3a0c84168a894c7e5
Autor:
Lianhui Sun, Guangjian Fan, Peipei Shan, Xiaoying Qiu, Shuxian Dong, Lujian Liao, Chunlei Yu, Tingting Wang, Xiaoyang Gu, Qian Li, Xiaoyu Song, Liu Cao, Xiaotao Li, Yongping Cui, Shengping Zhang, Chuangui Wang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
In conditions of energy stress cells reduce transcription of ribosomal RNA (rRNA) to maintain cell survival. Here, the authors show that energy stress induces an AMPK-dependent phosphorylation of Sirt7, which promotes its ubiquitin-independent degrad
Externí odkaz:
https://doaj.org/article/f5eff28dc2384939a26d207ce876a68f
Autor:
Qian Huang, Chuanyuan Li, Ling Tian, Xinjian Liu, Yuntao Luo, Minghui Zhao, Yiwei Wang, Yanping Gong, Lianhui Sun, Shengping Zhang, Chenyun Dai, Jingjing Ma, Yang Yu, Xiao Feng, Zhengxiang Zhang, Ling Zhou, Min Wang, Sijia He, Jin Cheng
Purpose:Tumor repopulation is known as a major cause of treatment failure and/or tumor recurrence after radiotherapy. The underlying mechanism remains unclear. Our previous study demonstrated that irradiated apoptotic cells mediated tumor repopulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30710393626e2314046032a38a834e96
https://doi.org/10.1158/1078-0432.c.6528110
https://doi.org/10.1158/1078-0432.c.6528110
Autor:
Qian Huang, Chuanyuan Li, Ling Tian, Xinjian Liu, Yuntao Luo, Minghui Zhao, Yiwei Wang, Yanping Gong, Lianhui Sun, Shengping Zhang, Chenyun Dai, Jingjing Ma, Yang Yu, Xiao Feng, Zhengxiang Zhang, Ling Zhou, Min Wang, Sijia He, Jin Cheng
Supplementary Figures and Tables. // Figure S1, Survival fractions. Figure S2, Linearity of bioluminescence signals vs. Fluc-GFP-labeled tumor cell numbers. Figure S3, Cisplatin-induced dying tumor cells stimulated living tumor cell growth. Figure S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017328fd650901456ef7f4ed6100970d
https://doi.org/10.1158/1078-0432.22472087.v1
https://doi.org/10.1158/1078-0432.22472087.v1
Autor:
Shujie Xia, Shengping Zhang, Yang Han, Xiaohong Zhang, Liu Cao, Chuangui Wang, Yan Zhang, Zhan Shi, Lianhui Sun, Chen Hu, Guangjian Fan, Baokun He, Qingqing Yang, Congli Hu, Xianmin Song, Ling Meng, Xing Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Drug resistance and tumor recurrence are major challenges in cancer treatment. Cancer cells often display centrosome amplification. To maintain survival, cancer cells achieve bipolar division by clustering supernumerary centrosomes. Targeting centros
Autor:
Xinjian Liu, Minghui Zhao, Chuangui Wang, Lianhui Sun, Yiwei Wang, Yuntao Luo, Ling Tian, Sijia He, Zhengxiang Zhang, Jin Cheng, Qian Huang, Chuan-Yuan Li
Publikováno v:
Cell Death and Disease, Vol 9, Iss 6, Pp 1-13 (2018)
Cell Death & Disease
Cell Death & Disease
Tumor repopulation during therapy is an important cause of treatment failure. Strategies to overcome repopulation are arising in parallel with advances in the comprehension of underlying biological mechanisms. Here, we reveal a new mechanism by which
Autor:
Yongping Cui, Shengping Zhang, Lianhui Sun, Tingting Wang, Li Qian, Lujian Liao, Xiaoyu Song, Chuangui Wang, Guangjian Fan, Chunlei Yu, Xiaotao Li, Peipei Shan, Shuxian Dong, Xiaoyang Gu, Liu Cao, Xiaoying Qiu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Nature Communications
Nature Communications
Maintenance of energy homeostasis is essential for cell survival. Here, we report that the ATP- and ubiquitin-independent REGγ-proteasome system plays a role in maintaining energy homeostasis and cell survival during energy starvation via repressing