Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Liangyou Rui"'
Autor:
Yina Wang, Liangyou Rui
Publikováno v:
Onco, Vol 4, Iss 3, Pp 217-231 (2024)
Liver cancer imposes a pervasive global health challenge, ranking among the most prevalent cancers worldwide. Its prevalence and mortality rates are on a concerning upward trajectory and exacerbated by the dearth of efficacious treatment options. The
Externí odkaz:
https://doaj.org/article/c60e0ebbb9a340b3864bbeccea72390e
Autor:
Yuan Li, Min‐Hyun Kim, Lin Jiang, Lorelei Baron, Latrice D. Faulkner, David P. Olson, Xingyu Li, Noam Gannot, Peng Li, Liangyou Rui
Publikováno v:
Advanced Science, Vol 11, Iss 31, Pp n/a-n/a (2024)
Abstract SH2B1 mutations are associated with obesity, type 2 diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD) in humans. Global deletion of Sh2b1 results in severe obesity, type 2 diabetes, and MASLD in mice. Neuron‐
Externí odkaz:
https://doaj.org/article/6051cca2d78b4984b2642ef97c35fb21
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113875- (2024)
Summary: Liver injury stimulates hepatocyte replication and hepatic stellate cell (HSC) activation, thereby driving liver regeneration. Aberrant HSC activation induces liver fibrosis. However, mechanisms underlying liver regeneration and fibrosis rem
Externí odkaz:
https://doaj.org/article/b2b79695c47c4a8bbdd79f4609a8adfd
Autor:
Qianqian Kang, Xiaorong Zhu, Decheng Ren, Alexander Ky, Ormond A. MacDougald, Robert W. O'Rourke, Liangyou Rui
Publikováno v:
Advanced Science, Vol 10, Iss 28, Pp n/a-n/a (2023)
Abstract White adipose tissue (WAT) lipolysis releases free fatty acids as a key energy substance to support metabolism in fasting, cold exposure, and exercise. Atgl, in concert with Cgi‐58, catalyzes the first lipolytic reaction. The sympathetic n
Externí odkaz:
https://doaj.org/article/423e17ecec094af0a0625656f8719ffa
Autor:
Zhiguo Zhang, Xiao Zhong, Hong Shen, Liang Sheng, Suthat Liangpunsakul, Anna S. Lok, M. Bishr Omary, Shaomeng Wang, Liangyou Rui
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Excessive expansion of cholangiocytes in the liver leads to ductular reaction and liver disease. Here, the authors show that genetic ablation, or pharmacological inhibition, of biliary NIK blocks ductular reaction, liver inflammation, and liver fibro
Externí odkaz:
https://doaj.org/article/7fee224b807148319c3090bb8e5f8b5c
LepRb+ cell–specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice
Autor:
Min-Hyun Kim, Yuan Li, Qiantao Zheng, Lin Jiang, Martin G. Myers Jr., Wen-Shu Wu, Liangyou Rui
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Leptin exerts its biological actions by activating the long-form leptin receptor (LepRb). LepRb signaling impairment and leptin resistance are believed to cause obesity. The transcription factor Slug — also known as Snai2 — recruits epigenetic mo
Externí odkaz:
https://doaj.org/article/45d6f580bfb94b69a4f1eac66be0f531
Autor:
Xiao Zhong, Zhiguo Zhang, Hong Shen, Yi Xiong, Yatrik M. Shah, Yong Liu, Xue‐Gong Fan, Liangyou Rui
Publikováno v:
Hepatology Communications, Vol 5, Iss 10, Pp 1704-1720 (2021)
Drug‐induced hepatotoxicity limits development of new effective medications. Drugs and numerous endogenous/exogenous agents are metabolized/detoxified by hepatocytes, during which reactive oxygen species (ROS) are generated as a by‐product. ROS h
Externí odkaz:
https://doaj.org/article/ab8559975f474835b9f621ec3bf225da
Autor:
Xiaojuan Han, Yuan Liu, Yan Dai, Tianshu Xu, Qinghui Hu, Xiaolan Yi, Liangyou Rui, Gang Hu, Jun Hu
Publikováno v:
Redox Biology, Vol 52, Iss , Pp 102308- (2022)
The incidence of Parkinson's disease (PD) has increased tremendously, especially in the aged population and people with metabolic dysfunction; however, its underlying molecular mechanisms remain unclear. SH2B1, an intracellular adaptor protein, contr
Externí odkaz:
https://doaj.org/article/9f5c50071e5d40d99cdf9e9d1f0c2cbc
Autor:
Haibin Zhou, Jianfeng Lu, Krishnapriya Chinnaswamy, Jeanne A. Stuckey, Liu Liu, Donna McEachern, Chao-Yie Yang, Denzil Bernard, Hong Shen, Liangyou Rui, Yi Sun, Shaomeng Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Activation of cullin-RING ligases can be inhibited by targeting DCN1, but selective DCN1 inhibitors with in vivo activity are lacking. Here, the authors develop covalent DCN1 inhibitors that selectively and potently inhibit cullin-3 activation and do
Externí odkaz:
https://doaj.org/article/f1b1354b41f3482fb5e78275ffe16f27
Autor:
Lin Jiang, Haoran Su, Xiaoyin Wu, Hong Shen, Min-Hyun Kim, Yuan Li, Martin G. Myers, Chung Owyang, Liangyou Rui
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Leptin regulates the sympathetic nervous system, energy expenditure and body weight through incompletely understood mechanisms. Here the authors report that Sh2b1 in leptin receptor positive neurons mediates the ability of leptin to stimulate sympath
Externí odkaz:
https://doaj.org/article/63894fb821634352a34440714451b55e