Výsledky vyhledávání - "Liangyan Zhu"

Akademický článek

Photoredox/Enzymatic Catalysis Enabling Redox-Neutral Decarboxylative Asymmetric C–C Coupling for Asymmetric Synthesis of Chiral 1,2-Amino Alcohols

Autor: Yiyin Liu, Liangyan Zhu, Xuemei Li, Yunfeng Cui, Atefeh Roosta, Jinhui Feng, Xi Chen, Peiyuan Yao, Qiaqing Wu, Dunming Zhu

Publikováno v: JACS Au, Vol 3, Iss 11, Pp 3005-3013 (2023)

Externí odkaz: https://doaj.org/article/1f06c94be1654259afaa478e48579992

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Akademický článek

Synthesis of single stereoisomers of 2,2-disubstituted 3-hydroxycyclohexane-1-ones via enzymatic desymmetric reduction of the 1,3-cyclohexanediones

Autor: Liangyan Zhu, Yunfeng Cui, Xi Chen, Hongliu Zhang, Jinhui Feng, Qiaqing Wu, Dunming Zhu

Publikováno v: Green Synthesis and Catalysis, Vol 2, Iss 3, Pp 320-323 (2021)

Chiral 3-hydroxycyclohexane-1-ones are widely used as building blocks in the synthesis of natural products and bioactive compounds, and preparation of their single stereoisomers is still quite challenging. Through screening the available carbonyl red

Externí odkaz: https://doaj.org/article/1f399f8111134481be81d0bb58de9a62

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Directed evolution of an alcohol dehydrogenase for the desymmetric reduction of 2,2-disubstituted cyclopenta-1,3-diones by enzymatic hydrogen transfer

Autor: Hongliu Zhang, Liangyan Zhu, Jinhui Feng, Xiangtao Liu, Xi Chen, Qiaqing Wu, Dunming Zhu

Publikováno v: Catalysis Science & Technology. 12:5841-5849

Directed evolution of carbonyl reductase TbADH created mutant Tb2 with balanced activity toward ethyl secodione and isopropanol, enabling the desymmetric reduction of ethyl secodione to give (13R,17S)-ethyl secol with 94% yield, >99% ee and >99% de.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c98d1811fa38be925955ed0f6adf14aa
https://doi.org/10.1039/d2cy00559j

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Highly Diastereoselective Synthesis of 2,2-Disubstituted Cyclopentane-1,3-diols via Stepwise Ketone Reduction Enabling Concise Chirality Construction

Autor: Bu Dandan, Jianjiong Li, Liangyan Zhu, Qin Wang, Jingyao Gong, Dunming Zhu, Jinhui Feng, Qiaqing Wu, Xi Chen, Hongliu Zhang

Publikováno v: The Journal of Organic Chemistry. 85:9599-9606

A series of 2,2-disubstituted trans,cis-cyclopentane-1,3-diols were synthesized in >99% dr through enzymatic reduction of enantiopure 2,2-disubstituted 3-hydroxycyclopentane-1-ones, which were prepared by highly stereoselective enzymatic reduction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1b8071ddd7ae05c90bfcbb8a208399
https://doi.org/10.1021/acs.joc.0c00851

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Engineering a Carbonyl Reductase for Scalable Preparation of (S)-3-Cyclopentyl-3-hydroxypropanenitrile, the Key Building Block of Ruxolitinib

Autor: Yunfeng Cui, Liangyan Zhu, Xi Chen, Jinhui Feng, Qiaqing Wu, Dunming Zhu

Publikováno v: Chembiochem : a European journal of chemical biology. 23(5)

(S)-3-Cyclopentyl-3-hydroxypropanenitrile is the key precursor for the synthesis of ruxolitinib. The bioreduction of 3-cyclopentyl-3-ketopropanenitrile (1 a) offers an attractive method to access this important compound. A carbonyl reductase (PhADH)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e2e7fae050a0792aa039ede823636e1
https://pubmed.ncbi.nlm.nih.gov/34951083

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