Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Liangmiao, Wu"'
Publikováno v:
Brain Research Bulletin, Vol 217, Iss , Pp 111084- (2024)
Subarachnoid hemorrhage (SAH) is a severe neurological event lacking of effective therapy. Early brain injury (EBI) and delayed neurological dysfunction are important cause in the poor prognosis of patients with SAH. Nucleotide-binding oligomerizatio
Externí odkaz:
https://doaj.org/article/e0674f343d9d45dd979aa0d3095bb956
Publikováno v:
Brain and Behavior, Vol 12, Iss 7, Pp n/a-n/a (2022)
Abstract Introduction The bilateral common carotid artery occlusion (BCCAO) rat model is an ideal animal model for simulating the pathology of chronic brain hypoperfusion in humans. However, dynamic changes in neuronal activity, cellular edema, and n
Externí odkaz:
https://doaj.org/article/a90e89fd1574494c91fbc11316b81371
Autor:
Mei Jing, Yun Cen, Fangfang Gao, Ting Wang, Jinxin Jiang, Qianqian Jian, Liangmiao Wu, Baojian Guo, Fangcheng Luo, Gaoxiao Zhang, Ying Wang, Lipeng Xu, Zaijun Zhang, Yewei Sun, Yuqiang Wang
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Diabetic kidney disease (DKD) is the leading cause of end-stage renal failure, but therapeutic options for nephroprotection are limited. Oxidative stress plays a key role in the pathogenesis of DKD. Our previous studies demonstrated that tetramethylp
Externí odkaz:
https://doaj.org/article/7beeec539874415388322609713d303f
Autor:
Baojian Guo, Liangmiao Wu, Zeyu Zhu, Zaijun Zhang, Gaoxiao Zhang, Yuqiang Wang, Yewei Sun, Haiyun Chen, Zhiyang Su, Chunhui Huang, Guiliang Zhang, Jiehong Cheng, Xifei Yang, Jiahui Wu
Publikováno v:
Journal of Molecular Neuroscience. 71:1456-1466
T-006, a small-molecule compound derived from tetramethylpyrazine (TMP), has potential for the treatment of neurological diseases. In order to investigate the effect of T-006 prophylactic treatment on an Alzheimer's disease (AD) model and identify th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766d6f00561d4be89b41852d6c8c0226
https://doi.org/10.1007/s12031-020-01762-x
https://doi.org/10.1007/s12031-020-01762-x
Autor:
Yifan Han, Zaijun Zhang, Yuqiang Wang, Baojian Guo, Shengquan Hu, Zheng Liu, Jiajun Wang, Liangmiao Wu, Guozhen Cui, Yewei Sun, Fangcheng Luo, Ziyan Liu, Shinghung Mak, Gaoxiao Zhang
Publikováno v:
ACS Chemical Neuroscience. 11:314-327
We have previously designed and synthesized a series of novel memantine nitrates, and some of them have shown neuroprotective effects; however, the detailed mechanisms remain unknown. In this study, we demonstrated that MN-12, one of the memantine ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::405b3270de05ca8f0ae445efcc67ff4b
https://doi.org/10.1021/acschemneuro.9b00242
https://doi.org/10.1021/acschemneuro.9b00242
Autor:
Baojian Guo, Mei Jing, Lipeng Xu, Yuqiang Wang, Gaoxiao Zhang, Yewei Sun, Jinxin Jiang, Qianqian Jian, Fangfang Gao, Yun Cen, Ting Wang, Ying Wang, Zaijun Zhang, Liangmiao Wu, Fangcheng Luo
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Diabetic kidney disease (DKD) is the leading cause of end-stage renal failure, but therapeutic options for nephroprotection are limited. Oxidative stress plays a key role in the pathogenesis of DKD. Our previous studies demonstrated that tetramethylp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2f1e17a1a75511db8b44123e03df6c
https://www.frontiersin.org/articles/10.3389/fphar.2021.680336/full
https://www.frontiersin.org/articles/10.3389/fphar.2021.680336/full
Autor:
Zheng Liu, Ling Zha, Yuqiang Wang, Gaoxiao Zhang, Zhixiang Zhang, Liangmiao Wu, Fangcheng Luo, Fangfang Gao, Guoqing Xie, Yewei Sun, Zaijun Zhang, Guangying Chen
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 77(5)
Pulmonary arterial hypertension (PAH) is a rare, progressive pulmonary vascular disease with limited therapeutic options. Pulmonary circulation resistance, pulmonary vascular remodeling, and over-activated NMDARs (N-methyl-d-aspartate receptors) play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d65124d506dbf856c714b530964de3
https://pubmed.ncbi.nlm.nih.gov/33979190
https://pubmed.ncbi.nlm.nih.gov/33979190
Autor:
Yifan Han, Liangmiao Wu, Ling Zha, Shing Hung Mak, Ning Li, Xifei Yang, Zaijun Zhang, Yuqiang Wang, Maggie Pui Man Hoi, Gaoxiao Zhang, Xinhua Zhou, Yewei Sun, Zhiyang Su, Yiwan Cao
Publikováno v:
Aging Cell
Alzheimer's disease (AD) is a leading cause of dementia in elderly individuals and therapeutic options for AD are very limited. Over‐activation of N‐methyl‐D‐aspartate (NMDA) receptors, amyloid β (Aβ) aggregation, a decrease in cerebral blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd901e15b2def0be0a40d8ec9054bbe7
https://pubmed.ncbi.nlm.nih.gov/33955647
https://pubmed.ncbi.nlm.nih.gov/33955647
Background Duchenne muscular dystrophy (DMD) is an X-linked inherited neuromuscular disorder due to mutations in the dystrophin gene. Animal models that accurately reflect pathological conditions and disease characteristics are key factors in the dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c27a8ec3e37acf64acc474c7cdc2252
Autor:
Baojian Guo, Shupeng Li, Jie Cao, Chengyou Zheng, Zaijun Zhang, Jing Wen, Pei Yu, Liangmiao Wu, Yangwen Luo, Gaoxiao Zhang, Fengjiao Wang, Xifei Yang, Shangming Li, Yuqiang Wang, Yewei Sun
Publikováno v:
Neuropharmacology. 182
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive loss of upper and lower motor neurons that results in skeletal muscle atrophy, weakness and paralysis. Oxidative stress plays a key role in the path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27196f69c6642f5d3f67ee0bf8b5f69
https://pubmed.ncbi.nlm.nih.gov/33152451
https://pubmed.ncbi.nlm.nih.gov/33152451