Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Lianghong Zheng"'
Autor:
Juan Wang, Liu Yang, Yanjun Diao, Jiayun Liu, Jinjie Li, Rui Li, Lianghong Zheng, Kang Zhang, Yueyun Ma, Xiaoke Hao
Publikováno v:
Journal of International Medical Research, Vol 49 (2021)
Objective To evaluate the performance of a DNA methylation-based digital droplet polymerase chain reaction (ddPCR) assay to detect aberrant DNA methylation in cell-free DNA (cfDNA) and to determine its application in the detection of hepatocellular c
Externí odkaz:
https://doaj.org/article/30e6d9bf07404c42816da95741a56d6e
Autor:
Changhe Wang, Xinjiang Kang, Li Zhou, Zuying Chai, Qihui Wu, Rong Huang, Huadong Xu, Meiqin Hu, Xiaoxuan Sun, Suhua Sun, Jie Li, Ruiying Jiao, Panli Zuo, Lianghong Zheng, Zhenyu Yue, Zhuan Zhou
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Mutations in the parkin, an ubiquitin ligase, are linked to Parkinson’s disease. Here the authors show that synaptotagmin-11 is a parkin substrate and that its upregulation affects dopamine release, triggers degeneration, and causes motor impairmen
Externí odkaz:
https://doaj.org/article/69b97946de444a3499ffefdcfb3fdb59
Autor:
Wei Xiong, Tao Liu, Yeshi Wang, Xiaowei Chen, Lei Sun, Ning Guo, Hui Zheng, Lianghong Zheng, Martial Ruat, Weiping Han, Claire Xi Zhang, Zhuan Zhou
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e24573 (2011)
AIM: Neurotransmitter release is elicited by an elevation of intracellular Ca(2+) concentration ([Ca(2+)](i)). The action potential triggers Ca(2+) influx through Ca(2+) channels which causes local changes of [Ca(2+)](i) for vesicle release. However,
Externí odkaz:
https://doaj.org/article/566ac8c9e37b43e1ae677a1c60d70953
Publikováno v:
Mathematical Methods in the Applied Sciences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c9ac4677b6ec81d5474bd17bd906601
https://doi.org/10.1002/mma.8574
https://doi.org/10.1002/mma.8574
Autor:
Ming Gao, Ian Ziyar, Ting Chen, Xuan Zhang, Xiaohong Liu, Jian Yang, Yong Liang, Winston Wang, Johnson Y.N. Lau, Ruiyun Deng, Zhihan Yan, Linsen Ye, Lianghong Zheng, Ye Sang, Kai Wang, Weimin Li, Laurance L Lau, Xiaoguang Zou, Oulan Li, Lingyan Zhang, Kang Zhang, Manson Fok, Wen Chen, Evis Sala, Longjiang Zhang, Zehong Yang, Jin Wang, Guiping Lin, Jun Shen, Tao Xu, Guangming Lu, Weihua Liao, Chengdi Wang, Zhongguo Zhou, Tianxin Lin, Charlotte Zhang, Tao Yu, Long Mo, Wenhua Liang, Andrea Olvera, Guangyu Wang, Jianxing He, Carola-Bibiane Schönlieb, Huimin Cai, Jichan Shi, Guiqun Cao, Zhihuan Li, Michael S. Roberts, Wei Chen, Wenqin Xu, Lei Yang, Xingwang Wu, Jun Liu
Publikováno v:
Nature biomedical engineering
Common lung diseases are first diagnosed using chest X-rays. Here, we show that a fully automated deep-learning pipeline for the standardization of chest X-ray images, for the visualization of lesions and for disease diagnosis can identify viral pneu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74f3d319f5574d7e1699ce7b03ed207
https://doi.org/10.1038/s41551-021-00704-1
https://doi.org/10.1038/s41551-021-00704-1
Autor:
Xin Fu, Jie Zhu, Yaou Duan, Gen Li, Huimin Cai, Lianghong Zheng, Hao Qian, Changjun Zhang, Zibing Jin, Xiang-Dong Fu, Kang Zhang
In this study, we developed an in-situ cellular reprogramming strategy for potent restoration of vision in advanced/end-stage retinitis pigmentosa (RP). Via repressing PTB, an RNA binding protein critical for converting non-neuronal cells to the neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724ad598bc6fb3ea687ef355f7d22e0d
https://doi.org/10.1101/2020.04.08.030981
https://doi.org/10.1101/2020.04.08.030981
Autor:
Gen Li, Guangxi Zang, Daniel Zhang, Qingli Quan, Ru Zhang, Wenge Hao, Jian-Kang Zhu, Edward Zhang, Xinping Cui, Xin Sun, Ian Ziyar, Runze Zhang, Zhiying Ou, Charlotte Zhang, Kang Zhang, Huiyan Luo, Oulan Li, Yingyi He, Xiaohong Zhang, Tina Poon, Linhai Cheng, Xiaoqiong Gu, Wei Wei, Shaoqing Wu, Zhihuan Li, Taylor Shimizu, Meixing Yu, Liya He, Lianghong Zheng, Jie Zhu, Hua Jiang, Jiayi Wang
Publikováno v:
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-10 (2020)
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-10 (2020)
The ability to identify a specific type of leukemia using minimally invasive biopsies holds great promise to improve the diagnosis, treatment selection, and prognosis prediction of patients. Using genome-wide methylation profiling and machine learnin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66efd4611c9a81ef70b56939da0ec61d
https://doi.org/10.1038/s41392-019-0090-5
https://doi.org/10.1038/s41392-019-0090-5
Autor:
Shuting Kuo, Zhuan Zhou, Xi Wu, Feipeng Zhu, Quanfeng Zhang, Yinglin Li, Changhe Wang, Qihui Wu, Bin Liu, Lianghong Zheng
Publikováno v:
The Journal of Neuroscience. 39:199-211
Dynamin 1 (dyn1) is required for clathrin-mediated endocytosis in most secretory (neuronal and neuroendocrine) cells. There are two modes of Ca2+-dependent catecholamine release from single dense-core vesicles: full-quantal (quantal) and subquantal i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbceeebf106a3df4c428336037e0d3ae
https://doi.org/10.1523/jneurosci.1255-18.2018
https://doi.org/10.1523/jneurosci.1255-18.2018
Autor:
Li Mingli, Sasa Teng, Jie Li, Zhiren Rao, Suhua Sun, Ning Guo, Changhe Wang, Lianghong Zheng, Li Wang, Zhuan Zhou, Feipeng Zhu, Yingfei Xiong
Publikováno v:
The Journal of Physiology. 596:1931-1947
Key points Similar to neurons, astrocytes actively participate in synaptic transmission via releasing gliotransmitters. The Ca2+ -dependent release of gliotransmitters includes glutamate and ATP. Following an 'on-cell-like' mechanical stimulus to a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3af23fe0fb1f8e0c17a8f76ee8dfcd78
https://doi.org/10.1113/jp275805
https://doi.org/10.1113/jp275805
Autor:
Zuo Panli, Lianghong Zheng, Zhenyu Yue, Ruiying Jiao, Zuying Chai, Zhuan Zhou, Xinjiang Kang, Suhua Sun, Li Zhou, Changhe Wang, Xiaoxuan Sun, Huadong Xu, Qihui Wu, Meiqin Hu, Rong Huang, Jie Li
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Loss-of-function mutations in Parkin are the most common causes of autosomal recessive Parkinson’s disease (PD). Many putative substrates of parkin have been reported; their pathogenic roles, however, remain obscure due to poor characterization, pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a16b2323696c3a0c1f13c211b2574fc
https://doaj.org/article/69b97946de444a3499ffefdcfb3fdb59
https://doaj.org/article/69b97946de444a3499ffefdcfb3fdb59