Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lianghe Wang"'
Autor:
Huimin Wang, Tony Johnson, Sameer Kawatkar, Peng Wang, Lakshmaiah Gingipalli, Scott D. Edmondson, Jon Read, Scott Boyd, Timothy Ikeda, Andrew Pike, Qibin Su, Olivier Lorthioir, Lianghe Wang, Hannah Dry, Hannah Pollard, Barlaam Bernard Christophe, Haiyun Wang, Scott Boiko
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127523
Hybridisation of amino-pyrimidine based SYK inhibitors (e.g. 1a) with previously reported diamine-based SYK inhibitors (e.g. TAK-659) led to the identification and optimisation of a novel pyrimidine-based series of potent and selective SYK inhibitors
Autor:
Neil P. Grimster, Lakshmaiah Gingipalli, Bernard Barlaam, Qibin Su, XiaoLan Zheng, David Watson, Haixia Wang, Iain Simpson, Andy Pike, Amber Balazs, Scott Boiko, Timothy P. Ikeda, Anna C. Impastato, Natalie H. Jones, Sameer Kawatkar, Paul Kemmitt, Scott Lamont, Joe Patel, Jon Read, Ujjal Sarkar, Li Sha, Ronald C. Tomlinson, Haiyun Wang, David M. Wilson, Troy E. Zehnder, Lianghe Wang, Peng Wang, Frederick W. Goldberg, Wenlin Shao, Stephen Fawell, Hannah Dry, James E. Dowling, Scott D. Edmondson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127433
Spleen tyrosine kinase (SYK) is a non-receptor cytosolic kinase. Due to its pivotal role in B cell receptor and Fc-receptor signaling, inhibition of SYK has been targeted in a variety of disease areas. Herein, we report the optimization of a series o
Publikováno v:
Science Bulletin. 54:2830-2838
Unlike the typical climacteric fruits, persimmons (Diospyros kaki Thunb.) produce higher levels of ethylene when they are detached from trees at a younger stage. In order to obtain detailed information on the role of abscisic acid (ABA) in ripening,
Publikováno v:
Chinese Science Bulletin. 54:3990-3990
Publikováno v:
European Journal of Gynaecological Oncology; 2012, Vol. 33 Issue 4, p423-424, 2p