Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lianghe Mei"'
Autor:
Shijie Liu, Peipei Guo, Kun Wang, Shaoying Zhang, Ya Li, Juwen Shen, Lianghe Mei, Yangliang Ye, Qiansen Zhang, Huaiyu Yang
Publikováno v:
Journal of Medicinal Chemistry. 65:10285-10299
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16d91b64e0cd160ed6819d1cc02b9946
https://doi.org/10.1021/acs.jmedchem.1c02115
https://doi.org/10.1021/acs.jmedchem.1c02115
Autor:
Lianghe Mei, Lansong Xu, Sanan Wu, Yafang Wang, Chao Xu, Lin Wang, Xingyu Zhang, Chengcheng Yu, Hualiang Jiang, Xianglei Zhang, Fang Bai, Chengying Xie
Publikováno v:
European Journal of Medicinal Chemistry. 257:115472
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::598272b7bb59848341a0e0665c11cacb
https://doi.org/10.1016/j.ejmech.2023.115472
https://doi.org/10.1016/j.ejmech.2023.115472
Autor:
Shijie, Liu, Peipei, Guo, Kun, Wang, Shaoying, Zhang, Ya, Li, Juwen, Shen, Lianghe, Mei, Yangliang, Ye, Qiansen, Zhang, Huaiyu, Yang
Publikováno v:
Journal of medicinal chemistry. 65(15)
Under the known pharmacological activation mechanisms, activators allosterically or directly open potassium channel gates. However, herein, molecular dynamics simulations on TREK-1, a member of the channel class gated at the filter, suggested that ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::281d61557a4afef33773a496eac45d5b
https://pubmed.ncbi.nlm.nih.gov/35878013
https://pubmed.ncbi.nlm.nih.gov/35878013
Autor:
Yanxin Che, Fei Guo, Huaiyu Yang, Yang Li, Yuqin Ma, Jie Fu, Qiansen Zhang, Lianghe Mei, Qichao Luo
Publikováno v:
Journal of Medicinal Chemistry. 63:10972-10983
Modulators can be designed to stabilize the inactive and active states of ion channels, but whether intermediate (IM) states of channel gating are druggable remains underexplored. In this study, using molecular dynamics simulations of the TWIK-relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0665a715e603b2c78af837eff3c4ba17
https://doi.org/10.1021/acs.jmedchem.0c00842
https://doi.org/10.1021/acs.jmedchem.0c00842
Autor:
Qiansen Zhang, Yimin Ren, Yiqing Mo, Peipei Guo, Ping Liao, Yuncheng Luo, Jie Mu, Zhuo Chen, Yang Zhang, Ya Li, Linghui Yang, Daqing Liao, Jie Fu, Juwen Shen, Wei Huang, Xuewen Xu, Yanyan Guo, Lianghe Mei, Yunxia Zuo, Jin Liu, Huaiyu Yang, Ruotian Jiang
Publikováno v:
Cell Res
Both opioids and nonsteroidal anti-inflammatory drugs (NSAIDS) produce deleterious side effects and fail to provide sustained relief in patients with chronic inflammatory pain. Peripheral neuroinflammation (PN) is critical for initiation and developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1144f841848addcee9162bf41adb1cac
https://europepmc.org/articles/PMC9061814/
https://europepmc.org/articles/PMC9061814/
Autor:
Ting Zhang, Liyuan Cao, Zhiyu Li, Lianghe Mei, Yaxi Yang, Chen Kaixian, Jinlei Bian, Bing Zhou, Haijing Cao, Wen Xu, Yuan Pei, Peizhuo Li, Hong Ding, Cheng Luo, Yuanqing Li, Yiman Guang, Zeng Hou
Publikováno v:
Bioorganicmedicinal chemistry. 52
Histone acetylation is one of the most essential parts of epigenetic modification, mediating a variety of complex biological functions. In these procedure, p300/CBP could catalyze the acetylation of lysine 27 on histone 3 (H3K27ac), and had been repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c663cc4cf80c1902f31fb770a03b4f4b
https://pubmed.ncbi.nlm.nih.gov/34801827
https://pubmed.ncbi.nlm.nih.gov/34801827
Autor:
Juan Yang, Shengdi Xia, Jiaxiang Liu, Zikun Yu, Lianghe Mei, Weiwei Lu, Yulin Chen, Shaopeng Chen, Xuan Wang, Xiaojie Lu
Publikováno v:
Tetrahedron Letters. 96:153732
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cbf2a13ff606e3948998d204c71e1ae
https://doi.org/10.1016/j.tetlet.2022.153732
https://doi.org/10.1016/j.tetlet.2022.153732
Autor:
Xiaoxiao Li, Huaiyu Yang, Jie Fu, Jiangqin Wang, Peipei Guo, Dongwu Lai, Sheng Ye, Jiangtao Guo, Qiansen Zhang, Dashuai Lv, Lianghe Mei
Publikováno v:
Cell Res
The voltage-gated potassium channel KCNQ2 is responsible for M-current in neurons and is an important drug target to treat epilepsy, pain and several other diseases related to neuronal hyper-excitability. A list of synthetic compounds have been devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb1b8ba655b63a5bd2c62dbd2509deb
https://pubmed.ncbi.nlm.nih.gov/32884139
https://pubmed.ncbi.nlm.nih.gov/32884139
Autor:
Jing Xing, Jie Han, Mingyue Zheng, Hualiang Jiang, Cheng Luo, Shili Wan, Huijin Feng, Lianghe Mei, Zhaojun Li, Bing Zhou, Hong Ding, Zhifeng Chen, Rukang Zhang, Yaxi Yang
Publikováno v:
Journal of medicinal chemistry. 63(3)
p300 and CREB-binding protein (CBP) are ubiquitously expressed pleiotropic lysine acetyltransferases and play a key role as transcriptional co-activators that are essential for a multitude of cellular processes. Despite great importance, there is a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b40e893a06dd4e81014bbfc22a468c8
https://pubmed.ncbi.nlm.nih.gov/31910017
https://pubmed.ncbi.nlm.nih.gov/31910017