Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Liangcai Hou"'
Autor:
Kai Sun, Fan Lu, Liangcai Hou, Xiong Zhang, Chunran Pan, Haigang Liu, Zehang Zheng, Zhou Guo, Zhaoxuan Ruan, Yanjun Hou, Jinming Zhang, Fengjing Guo, Wentao Zhu
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Z-DNA binding protein 1 (ZBP1) is a nucleic acid sensor that is involved in multiple inflammatory diseases, but whether and how it contributes to osteoarthritis (OA) are unclear. Methods Cartilage tissues were harvested from patie
Externí odkaz:
https://doaj.org/article/0af38da6199346bfb3e04df823d61627
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110741- (2024)
Summary: Osteoarthritis (OA) is a progressive degenerative joint disease, and the underlying molecular mechanisms of OA remain poorly understood. This study aimed to elucidate the relationship between mitochondrial autophagy and OA by identifying key
Externí odkaz:
https://doaj.org/article/5fcc3392826a4780951e76e6e811d2e4
Autor:
Jingting Xu, Zhaoxuan Ruan, Zhou Guo, Liangcai Hou, Genchun Wang, Zehang Zheng, Xiong Zhang, Haigang Liu, Kai Sun, Fengjing Guo
Publikováno v:
Bone & Joint Research, Vol 13, Iss 3, Pp 110-123 (2024)
Aims: Osteoarthritis (OA) is the most common chronic pathema of human joints. The pathogenesis is complex, involving physiological and mechanical factors. In previous studies, we found that ferroptosis is intimately related to OA, while the role of S
Externí odkaz:
https://doaj.org/article/bd074a90b237484faa68f1ebdcacbd21
Autor:
Liangcai Hou, Genchun Wang, Xiong Zhang, Fan Lu, Jingting Xu, Zhou Guo, Jiamin Lin, Zehang Zheng, Haigang Liu, Yanjun Hou, Kai Sun, Fengjing Guo
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108888- (2024)
Externí odkaz:
https://doaj.org/article/5ae49d18d94e4cae84802ac29cf6391d
Lipid peroxidation in osteoarthritis: focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis
Autor:
Xiong Zhang, Liangcai Hou, Zhou Guo, Genchun Wang, Jingting Xu, Zehang Zheng, Kai Sun, Fengjing Guo
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract Osteoarthritis (OA) is a multifactorial and increasingly prevalent degenerative disease that affects the whole joint. The pathogenesis of OA is poorly understood and there is a lack of therapeutic interventions to reverse the pathological pr
Externí odkaz:
https://doaj.org/article/87579b2e59174b4cb681a26955672487
Autor:
Kai Sun, Zhou Guo, Jinming Zhang, Liangcai Hou, Shuang Liang, Fan Lu, Genchun Wang, Jingting Xu, Xiong Zhang, Fengjing Guo, Wentao Zhu
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract Osteoarthritis (OA) is an age-related disease characterized by cartilage degeneration. TNFR1-associated death domain protein (TRADD) is a key upstream molecule of TNF-α signals but its role in OA pathogenesis is unknown. This study aimed to
Externí odkaz:
https://doaj.org/article/c0ab250f28e945459b3d31f3d1e6d231
Autor:
Liangcai Hou, Genchun Wang, Xiong Zhang, Fan Lu, Jingting Xu, Zhou Guo, Jiamin Lin, Zehang Zheng, Haigang Liu, Yanjun Hou, Kai Sun, Fengjing Guo
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107647- (2023)
Summary: Osteoarthritis (OA) is a prevalent degenerative disease of the elderly. The NRF2 antioxidant system plays a critical role in maintaining redox balance. Mitoquinone (MitoQ) is a mitochondria-targeted antioxidant. This research aimed to determ
Externí odkaz:
https://doaj.org/article/48b3a34bf585488093f3467555aa5300
Autor:
Zhou Guo, Jiamin Lin, Kai Sun, Jiayou Guo, Xudong Yao, Genchun Wang, Liangcai Hou, Jingting Xu, Jiachao Guo, Fengjing Guo
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/a4a1d164e8df4825bcb0fb3238770d98
Autor:
Zhou Guo, Jiamin Lin, Kai Sun, Jiayou Guo, Xudong Yao, Genchun Wang, Liangcai Hou, Jingting Xu, Jiachao Guo, Fengjing Guo
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Objective: Osteoarthritis (OA) is a common disease with a complex pathology including mechanical load, inflammation, and metabolic factors. Chondrocyte ferroptosis contributes to OA progression. Because iron deposition is a major pathological event i
Externí odkaz:
https://doaj.org/article/9933128e498c4a5e8494db12d8809d74
Autor:
Kai Sun, Liangcai Hou, Zhou Guo, Genchun Wang, Jiachao Guo, Jingting Xu, Xiong Zhang, Fengjing Guo
Publikováno v:
Free Radical Biology and Medicine. 200:87-101