Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Liang-Deng Nie"'
Publikováno v:
Tetrahedron: Asymmetry. 26:1037-1042
A stereoselective synthesis of the pharmaceutically useful pseudo-aminosugar (+)-valienamine 1 is described. Epoxide 2 was first prepared via four steps in 79.7% overall yield starting from the naturally abundant (−)-shikimic acid. Epoxide 2 was th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::816f6033f69908728af5c9cac9dd2daa
https://doi.org/10.1016/j.tetasy.2015.07.013
https://doi.org/10.1016/j.tetasy.2015.07.013
Publikováno v:
European Journal of Organic Chemistry. 2013:6389-6396
Total syntheses of (+)-valiolamine (1) and (–)-1-epi-valiolamine (2) from the naturally abundant (–)-shikimic acid are described. Ethyl 3-epi-5-O-methylsulfonyl-shikimate (3), as the key common intermediate, was first synthesized in five steps in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a905f50c6bacd7a2b796f81f531232ff
https://doi.org/10.1002/ejoc.201300804
https://doi.org/10.1002/ejoc.201300804
Publikováno v:
Tetrahedron: Asymmetry. 24:638-642
A novel azide-free asymmetric synthesis of oseltamivir phosphate 1 (Tamiflu®) starting from Roche’s epoxide is described. Roche epoxide 2 was converted into N -acetyl aminoalcohol 3 in 95% yield via a BF 3 ·OEt 2 -catalyzed epoxide-opening with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::531caf8be82e1bc07f638de85fbf01df
https://doi.org/10.1016/j.tetasy.2013.04.016
https://doi.org/10.1016/j.tetasy.2013.04.016
Publikováno v:
Chinese Journal of Chemistry. 30:2759-2766
All of the four stereoisomers of methyl 4,5-epoxy-3-hydroxy-cyclohex-1-ene-carboxylate (1a–1d) are useful chiral building blocks. Novel and efficient syntheses of these four epoxy chiral building blocks from naturally abundant (−)-shikimic acid (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::612b7aee6dc99d35c2ebcb1ac9f379a2
https://doi.org/10.1002/cjoc.201201000
https://doi.org/10.1002/cjoc.201201000
Publikováno v:
Tetrahedron: Asymmetry. 23:742-747
A novel and high-yielding asymmetric synthesis of oseltamivir phosphate 1 (Tamiflu®) is described. The target compound 1 was obtained in 55% overall yield via an 11-step asymmetric synthesis starting from the naturally abundant (−)-shikimic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d810ba759a775a3bef6a5ae824a80a99
https://doi.org/10.1016/j.tetasy.2012.05.014
https://doi.org/10.1016/j.tetasy.2012.05.014
Publikováno v:
Tetrahedron: Asymmetry. 22:1692-1699
A novel asymmetric synthesis of oseltamivir phosphate 1 from the naturally abundant (−)-shikimic acid via 3,4-cyclic sulfite intermediate 3 ( Scheme 1 ) is described. Target compound 1 was obtained in 39% overall yield from this nine-step synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bae87208fc520b6e24b72d94641a7bb
https://doi.org/10.1016/j.tetasy.2011.09.014
https://doi.org/10.1016/j.tetasy.2011.09.014
Publikováno v:
Synlett. 2011:1028-1032
A mild, efficient, general, and green method for the regenerationof carbonyl compounds from their corresponding oximes is described.Cupric salts promoted hydrolysis of oximes was studied, and thebest reaction conditions for the hydrolysis have been f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8accfaffbdcb97ec11d13cbf2e046eb1
https://doi.org/10.1055/s-0030-1259730
https://doi.org/10.1055/s-0030-1259730
Publikováno v:
Tetrahedron: Asymmetry. 21:277-284
The SN2 reaction of enantiomerically pure sulfonates with the tunable complex of R3N–R′COOH in toluene has been extensively studied. It was revealed that the molar ratio of the tertiary amines and carboxylic acids in the complex of R3NR′COOH is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9be2f033954d9e3b5fa58ac1e5a1ff87
https://doi.org/10.1016/j.tetasy.2009.12.028
https://doi.org/10.1016/j.tetasy.2009.12.028
Autor:
Xiao-Xin Shi, Liang-Deng Nie
Publikováno v:
Tetrahedron: Asymmetry. 20:124-129
Oseltamivir phosphate 1 was synthesized starting from a readily available acetonide, that is, ethyl (3 R ,4 S ,5 R )-3,4- O -isopropylidene shikimate 2 , through a new route via 11 steps and in 44% overall yield. The synthesis described in this artic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3663b2ed178f907ea5fe8c2d89fa52a7
https://doi.org/10.1016/j.tetasy.2008.11.027
https://doi.org/10.1016/j.tetasy.2008.11.027
Publikováno v:
ChemInform. 45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13b310243786236e880bac8a4d92a09b
https://doi.org/10.1002/chin.201410219
https://doi.org/10.1002/chin.201410219