Výsledky vyhledávání - "Liang Z. Yan"

Detection and control of aspartimide formation in the synthesis of cyclic peptides

Autor: Huaping Mo, Liang Z. Yan, M. Amin Khan, John P. Mayer, David B. Flora

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:1065-1068

Extensive two-dimensional NMR analysis was employed to characterize the structural identity of the macrocyclic peptide lactam and the imide analog, a major side reaction product when allyl ester was used to protect the side chain of aspartic acid. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2554d238ed6d13215184889034d7070a
https://doi.org/10.1016/j.bmcl.2004.12.025

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Synthesis of Peptides and Proteins without Cysteine Residues by Native Chemical Ligation Combined with Desulfurization

Autor: Philip E. Dawson, Liang Z. Yan

Publikováno v: Journal of the American Chemical Society. 123:526-533

The highly chemoselective reaction between unprotected peptides bearing an N-terminal Cys residue and a C-terminal thioester enables the total and semi-synthesis of complex polypeptides. Here we extend the utility of this native chemical ligation app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe568673d04ec0cf4bb6340d36a50e8
https://doi.org/10.1021/ja003265m

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Solution Structure of Carnobacteriocin B2 and Implications for Structure−Activity Relationships among Type IIa Bacteriocins from Lactic Acid Bacteria

Autor: Liang Z. Yan, John C. Vederas, David S. Wishart, Yunjun Wang, Matthias E. Henz, Michael E. Stiles, Nancy L. Fregeau Gallagher, Shengyong Chai, Alan C. Gibbs

Publikováno v: Biochemistry. 38:15438-15447

Carnobacteriocin B2 (CbnB2), a type IIa bacteriocin, is a 48 residue antimicrobial peptide from the lactic acid bacterium Carnobacterium pisicola LV17B. Type IIa bacteriocins have a conserved YGNGVXC sequence near the N-terminus and usually contain a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9e4cc407008c24f57386cbaaf81dba
https://doi.org/10.1021/bi991351x

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Effect of Amino Acid Substitutions on the Activity of Carnobacteriocin B2

Autor: Liang Z. Yan, Luis E. N. Quadri, Michael E. Stiles, John C. Vederas

Publikováno v: Journal of Biological Chemistry. 272:3384-3388

Carnobacteriocin B2, a 48-amino acid antimicrobial peptide containing a YGNGV motif that is produced by the lactic acid bacterium Carnobacterium piscicola LV17B, was overexpressed as fusion with maltose-binding protein in Escherichia coli. This fusio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c9270621ccd5c82c7cc525d893067ab
https://doi.org/10.1074/jbc.272.6.3384

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Synthesis of cyclic peptides through hydroxyl side-chain anchoring

Autor: Patrick Edwards, John P. Mayer, Liang Z. Yan, David B. Flora

Publikováno v: Tetrahedron Letters. 45:923-925

A general method was developed for the synthesis of serine or threonine containing cyclic peptides utilizing the β-hydroxyl side-chain of these residues as an anchor point to Wang resin. The peptide chain was assembled by conventional Fmoc/tBu solid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b061709fe9cfb528313b89d0682bc7d3
https://doi.org/10.1016/j.tetlet.2003.11.107

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