A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity.

Autor: Li YY; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China., Liang GD; Key Laboratory for Candidate Drug Design and Screening Based on Chemical Biology, College of Pharmacy, Inner Mongolia Medical University, Huhhot, 010110, China., Chen ZX; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China., Zhang K; Key Laboratory of Microbio and Infectious Disease Prevention & Control in Guizhou Province/Institute of Virology, School of Basic Medicine, Guizhou Medical University, Guiyang, 561113, China., Liang JL; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China., Jiang LR; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China., Yang SZ; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China., Jiang F; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China., Liu SW; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China., Yang J; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China. yj528@smu.edu.cn.

Publikováno v: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2024 Nov; Vol. 45 (11), pp. 2380-2393. Date of Electronic Publication: 2024 Jul 10.

Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing.

Autor: Zhang YL; Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi, China;National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Su WZ; Guangzhou Center for Disease Control and Prevention, Guangzhou 510000, Guangdong, China., Wang RC; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Li Y; Shandong Center for Disease Control and Prevention, Jinan 250000, Shandong, China., Zhang JF; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Liu SH; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Hu DH; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Xu CX; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Yin JY; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Yin QK; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., He Y; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Li F; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Fu SH; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Nie K; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Liang GD; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Tao Y; Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China., Xu ST; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China., Ma CF; Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi, China;Xi'an Center for Disease Control and Prevention, Xi'an 710054, Shaanxi, China., Wang HY; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

Publikováno v: Biomedical and environmental sciences : BES [Biomed Environ Sci] 2024 Mar 20; Vol. 37 (3), pp. 294-302.

Detection and evolutionary characterization of arboviruses in mosquitoes and biting midges on Hainan Island, China, 2019–2023.

Autor: Wu, Qun^1,2,3 (AUTHOR), Sun, Dingwei³ (AUTHOR), Zaman, Wahid^1,2 (AUTHOR), Wang, Fei^1,2 (AUTHOR), Huang, Doudou¹ (AUTHOR), Ma, Haixia¹ (AUTHOR), Wang, Shunlong^1,2 (AUTHOR), Liu, Ying³ (AUTHOR), Liu, Puyu³ (AUTHOR), Zeng, Xuexia³ (AUTHOR), Yuan, Zhiming^1,2 (AUTHOR) yzm@wh.iov.cn, Xia, Han^1,2,4 (AUTHOR) hanxia@wh.iov.cn

Publikováno v: PLoS Neglected Tropical Diseases. 10/31/2024, Vol. 18 Issue 10, p1-15. 15p.

Novel Bacillus strains from the human gut exert anticancer effects on a broad range of malignancy types.

Autor: Zhao MF; Department of Epidemiology, Public Health School, Harbin Medical University, Harbin, Heilongjiang Province, China., Liang GD; Department of Epidemiology, Public Health School, Harbin Medical University, Harbin, Heilongjiang Province, China., Zhou YJ; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, Heilongjiang Province, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, Heilongjiang Province, China., Chi ZP; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, Heilongjiang Province, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, Heilongjiang Province, China., Zhuang H; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, Heilongjiang Province, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, Heilongjiang Province, China., Zhu SL; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, Heilongjiang Province, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, Heilongjiang Province, China., Wang Y; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, Heilongjiang Province, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, Heilongjiang Province, China., Liu GR; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, Heilongjiang Province, China. grliu@hrbmu.edu.cn.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, Heilongjiang Province, China. grliu@hrbmu.edu.cn., Zhao JB; Department of Epidemiology, Public Health School, Harbin Medical University, Harbin, Heilongjiang Province, China. zhaojb168@sina.com., Liu SL; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, Heilongjiang Province, China. slliu@hrbmu.edu.cn.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, Heilongjiang Province, China. slliu@hrbmu.edu.cn.; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada. slliu@hrbmu.edu.cn.

Publikováno v: Investigational new drugs [Invest New Drugs] 2020 Oct; Vol. 38 (5), pp. 1373-1382. Date of Electronic Publication: 2020 Jul 31.

E. coli diversity: low in colorectal cancer.

Autor: Tang L; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, China.; Departments of Ecosystems and Public Health, University of Calgary, Calgary, Canada., Zhou YJ; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, China.; Present address: Department of Immunology, Capital Medical University, Beijing, China., Zhu S; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, China., Liang GD; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, China.; Department of Epidemiology, Public Health School, Harbin Medical University, Harbin, China., Zhuang H; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, China., Zhao MF; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, China.; Department of Epidemiology, Public Health School, Harbin Medical University, Harbin, China., Chang XY; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, China., Li HN; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, China., Liu Z; Department of Colorectal Surgery of the Second Affiliated Hospital, Harbin Medical University, Harbin, China.; Present address: Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Guo ZR; Department of Microbiology, Peking University Health Sciences Center, Beijing, China., Liu WQ; Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada.; Present address: Department of Clinical Neurosciences, University of Calgary, Calgary, Canada., He X; Department of Microbiology, Peking University Health Sciences Center, Beijing, China., Wang CX; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, China., Zhao DD; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, China., Li JJ; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, China., Mu XQ; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, China.; Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, China., Yao BQ; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, China., Li X; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, China.; Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, China., Li YG; Department of Infectious Diseases of the First Affiliated Hospital, Harbin Medical University, Harbin, China., Duo LB; Clinical Laboratory of Second Affiliated Hospital, Harbin Medical University, Harbin, China., Wang L; Clinical Laboratory of Second Affiliated Hospital, Harbin Medical University, Harbin, China., Johnston RN; Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada., Zhou J; Department of Hematology of the First Affiliated Hospital, Harbin Medical University, Harbin, China., Zhao JB; Department of Epidemiology, Public Health School, Harbin Medical University, Harbin, China., Liu GR; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, Harbin, 150081, China. grliu@hrbmu.edu.cn.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, China. grliu@hrbmu.edu.cn., Liu SL; Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, Harbin, 150081, China. slliu@hrbmu.edu.cn.; HMU-UCCSM Centre for Infection and Genomics, Harbin Medical University, Harbin, China. slliu@hrbmu.edu.cn.; Department of Microbiology, Peking University Health Sciences Center, Beijing, China. slliu@hrbmu.edu.cn.; Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada. slliu@hrbmu.edu.cn.; Translational Medicine Research and Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, China. slliu@hrbmu.edu.cn.; Department of Infectious Diseases of the First Affiliated Hospital, Harbin Medical University, Harbin, China. slliu@hrbmu.edu.cn.

Publikováno v: BMC medical genomics [BMC Med Genomics] 2020 Apr 06; Vol. 13 (1), pp. 59. Date of Electronic Publication: 2020 Apr 06.