Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Liang Fong-Wong"'
Autor:
Scott Ellis, Liang Fong-Wong, Sharifah Iqball, Vinay Thoree, Kyriacos A Mitrophanous, Katie Binley
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
The interest in integrase-defective lentiviral vectors (IDLVs) stems from their potential advantage of large cloning capacity and broad cell tropism while avoiding the possibility of insertional mutagenesis. Here, we directly compared the transducing
Externí odkaz:
https://doaj.org/article/4750e5f4e14146d5b05c0ccf43bf2cb4
Autor:
Gongyu Shi, Helen Scott, Nur Izzah Farhana Mohamad Azhar, Andriana Gialeli, Benjamin Clennell, Keng Siang Lee, Jenny Hurcombe, Daniel Whitcomb, Richard Coward, Liang-Fong Wong, Oscar Cordero-Llana, James B. Uney
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract We previously reported that kenpaullone, which inhibits GSK-3a/b and CDKs inhibited CCCP mediated mitochondrial depolarisation and augments the mitochondrial network. To investigate the actions of this class of drug further, we compared the
Externí odkaz:
https://doaj.org/article/0a873f3846674100ba0b71629afe0b9b
Autor:
Raffaele Simeoli, Karli Montague, Hefin R. Jones, Laura Castaldi, David Chambers, Jayne H. Kelleher, Valentina Vacca, Thomas Pitcher, John Grist, Hadil Al-Ahdal, Liang-Fong Wong, Mauro Perretti, Johnathan Lai, Peter Mouritzen, Paul Heppenstall, Marzia Malcangio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Exosomes are known to contain microRNAs (miRs). Here the authors show that dorsal root ganglion neurons release exosomes containing miR-21-5p, which contributes to inflammatory cell recruitment following peripheral nerve injury.
Externí odkaz:
https://doaj.org/article/985f58856e554adfb658898c61646afe
Autor:
Daisuke Ito, Darren Carwardine, Jon Prager, Liang Fong Wong, Masato Kitagawa, Nick Jeffery, Nicolas Granger
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213252 (2019)
Olfactory ensheathing cells are thought to support regeneration and remyelination of damaged axons when transplanted into spinal cord injuries. Following transplantation, improved locomotion has been detected in many laboratory models and in dogs wit
Externí odkaz:
https://doaj.org/article/d22e32ab8c4d40159d6a572716c20530
Autor:
Jon Prager, Joe Fenn, Mark Plested, Leticia Escauriaza, Tracy van der Merwe, Barbora King, Divya Chari, Liang‐Fong Wong, Nicolas Granger
Publikováno v:
Journal of tissue engineering and regenerative medicine. 16(9)
Spinal cord injury (SCI) can cause irreversible paralysis, with no regenerative treatment clinically available. Dogs with natural SCI present an established model and can facilitate translation of experimental findings in rodents to people. We conduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a47564bb66cee26e557ab00337eef7c
https://pubmed.ncbi.nlm.nih.gov/35686704
https://pubmed.ncbi.nlm.nih.gov/35686704
Autor:
Andriana Gialeli, Nicola Buckner, Liang-Fong Wong, Kevin C Kemp, Caroline A Rivers, Nicholas D. Allen, Helen L. Scott, Alastair Wilkins, Gongyu Shi, James B. Uney, Oscar Cordero-Llana
Publikováno v:
Buckner, N, Kemp, K C, Scott, H L, Shi, G, Rivers, C A, Gialeli, A, Wong, L-F, Cordero Llana, O, Allen, N, Wilkins, A & Uney, J B 2020, ' Abnormal scaffold attachment factor 1 expression and localisation in spinocerebellar ataxias and huntington’s chorea ', Brain Pathology . https://doi.org/10.1111/bpa.12872
Brain Pathology
Brain Pathology
SAFB1 is a DNA and RNA binding protein that is highly expressed in the cerebellum and hippocampus and is involved in the processing of coding and non‐coding RNAs, splicing and dendritic function. We analyzed SAFB1 expression in the post‐mortem br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d387dc2887fc0c2ce93f5d7fbe5b591
https://doi.org/10.1111/bpa.12872
https://doi.org/10.1111/bpa.12872
Publikováno v:
Barker, G R, Wong, L F, Uney, J B & Warburton, E C 2020, ' CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memory ', Learning and Memory, vol. 27, no. 2, pp. 45-51 . https://doi.org/10.1101/lm.050021.119
Learn Mem
Learn Mem
The medial prefrontal cortex (mPFC) is known to be critical for specific forms of long-term recognition memory, however the cellular mechanisms in the mPFC that underpin memory maintenance have not been well characterized. This study examined the imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621ffd7701c3430dff512db7762f3d4a
https://doi.org/10.1101/lm.050021.119
https://doi.org/10.1101/lm.050021.119
Autor:
Darren Carwardine, Jon Prager, Daisuke Ito, Prince Jiju, Liang-Fong Wong, Nicolas Granger, Divya M. Chari
Publikováno v:
Prager, J, Ito, D, Carwardine, D R, Jiji, P, Chari, D M, Granger, N & Wong, L-F 2021, ' Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury ', Experimental Neurology, vol. 340, 113660 . https://doi.org/10.1016/j.expneurol.2021.113660
Spinal cord injury (SCI) can cause chronic paralysis and incontinence and remains a major worldwide healthcare burden, with no regenerative treatment clinically available. Intraspinal transplantation of olfactory ensheathing cells (OECs) and injectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e5a79c5f494d18c35435be8008fd63
https://pubmed.ncbi.nlm.nih.gov/33647272
https://pubmed.ncbi.nlm.nih.gov/33647272
Autor:
John F Tarlton, Nicolas Granger, Jon B M Prager, Alexander M. Delaney, Divya M. Chari, Guillaume Chanoit, Liang-Fong Wong, Christopher F. Adams
Publikováno v:
Journal of Tissue Engineering
Journal of Tissue Engineering, Vol 11 (2020)
Prager, J, Adams, C F, Delaney, A M, Chanoit, G, Tarlton, J F, Wong, L-F, Chari, D M & Granger, N 2020, ' Stiffness-matched biomaterial implants for cell delivery : clinical, intraoperative ultrasound elastography provides a 'target' stiffness for hydrogel synthesis in spinal cord injury ', Journal of Tissue Engineering, vol. 11, pp. 2041731420934806 . https://doi.org/10.1177/2041731420934806
Journal of Tissue Engineering, Vol 11 (2020)
Prager, J, Adams, C F, Delaney, A M, Chanoit, G, Tarlton, J F, Wong, L-F, Chari, D M & Granger, N 2020, ' Stiffness-matched biomaterial implants for cell delivery : clinical, intraoperative ultrasound elastography provides a 'target' stiffness for hydrogel synthesis in spinal cord injury ', Journal of Tissue Engineering, vol. 11, pp. 2041731420934806 . https://doi.org/10.1177/2041731420934806
Safe hydrogel delivery requires stiffness-matching with host tissues to avoid iatrogenic damage and reduce inflammatory reactions. Hydrogel-encapsulated cell delivery is a promising combinatorial approach to spinal cord injury therapy, but a lack of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc3362fa3983d31a9507bafb615dc75
https://pubmed.ncbi.nlm.nih.gov/32670538
https://pubmed.ncbi.nlm.nih.gov/32670538
Publikováno v:
PLoS Biology, Vol 8, Iss 6, p e1000399 (2010)
Following trauma of the adult brain or spinal cord the injured axons of central neurons fail to regenerate or if intact display only limited anatomical plasticity through sprouting. Adult cortical neurons forming the corticospinal tract (CST) normall
Externí odkaz:
https://doaj.org/article/fbad2dc100a547e1b8b369e16fe7f3b2