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Vaccination with Span, an antigen guided by SARS-CoV-2 S protein evolution, protects against challenge with viral variants in mice.

Autor: Zhao, Yongliang, Ni, Wenjia, Liang, Simeng, Dong, Lianghui, Xiang, Min, Cai, Zeng, Niu, Danping, Zhang, Qiuhan, Wang, Dehe, Zheng, Yucheng, Zhang, Zhen, Zhou, Dan, Guo, Wenhua, Pan, Yongbing, Wu, Xiaoli, Yang, Yimin, Jing, Zhaofei, Jiang, Yongzhong, Chen, Yu, Yan, Huan

Publikováno v: Science Translational Medicine; 1/4/2023, Vol. 15 Issue 677, p1-14, 14p

Vaccination with S pan , an antigen guided by SARS-CoV-2 S protein evolution, protects against challenge with viral variants in mice.

Autor: Zhao Y; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China., Ni W; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China., Liang S; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China., Dong L; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China., Xiang M; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China., Cai Z; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China.; Institute for Vaccine Research, Animal Biosafety Level 3 Laboratory, Wuhan University, Wuhan 430072, Hubei, P.R. China., Niu D; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China., Zhang Q; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China., Wang D; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China., Zheng Y; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China., Zhang Z; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China., Zhou D; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China., Guo W; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China., Pan Y; Wuhan Institute of Biological Products Co. Ltd., Wuhan 430207, Hubei, P.R. China., Wu X; Wuhan Institute of Biological Products Co. Ltd., Wuhan 430207, Hubei, P.R. China., Yang Y; Wuhan Institute of Biological Products Co. Ltd., Wuhan 430207, Hubei, P.R. China., Jing Z; Wuhan Institute of Biological Products Co. Ltd., Wuhan 430207, Hubei, P.R. China., Jiang Y; Hubei Provincial Center for Diseases Control and Prevention, Wuhan 430079, Hubei, P.R. China., Chen Y; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China.; Institute for Vaccine Research, Animal Biosafety Level 3 Laboratory, Wuhan University, Wuhan 430072, Hubei, P.R. China., Yan H; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China.; Institute for Vaccine Research, Animal Biosafety Level 3 Laboratory, Wuhan University, Wuhan 430072, Hubei, P.R. China., Zhou Y; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China.; Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China.; Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430072, Hubei, P.R. China., Xu K; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China.; Institute for Vaccine Research, Animal Biosafety Level 3 Laboratory, Wuhan University, Wuhan 430072, Hubei, P.R. China.; Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China., Lan K; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China.; Institute for Vaccine Research, Animal Biosafety Level 3 Laboratory, Wuhan University, Wuhan 430072, Hubei, P.R. China.; Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan 430072, Hubei, P.R. China.; Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan 430072, Hubei, P.R. China.

Publikováno v: Science translational medicine [Sci Transl Med] 2023 Jan 04; Vol. 15 (677), pp. eabo3332. Date of Electronic Publication: 2023 Jan 04.