Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Lianfa Shi"'
Autor:
Yongrong Zhang, Shan Li, Zhiyong Yang, Lianfa Shi, Hua Yu, Rosangela Salerno-Goncalves, Ashley Saint Fleur, Hanping Feng
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 611-625 (2018)
Background & Aims: Clostridium difficile toxin A (TcdA) and C difficile toxin toxin B (TcdB), the major virulence factors of the bacterium, cause intestinal tissue damage and inflammation. Although the 2 toxins are homologous and share a similar doma
Externí odkaz:
https://doaj.org/article/fdacdf7c94c941a6bc7143daec5f33a3
Autor:
Hua Yu, Kevin Chen, Jianguo Wu, Zhiyong Yang, Lianfa Shi, Lydia L Barlow, David M Aronoff, Kevin W Garey, Tor C Savidge, Erik C von Rosenvinge, Ciaran P Kelly, Hanping Feng
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124235 (2015)
Toxemia can develop in Clostridium difficile-infected animals, and correlates with severe and fulminant disease outcomes. Circumstantial evidence suggests that toxemia may occur in patients with C. difficile infection (CDI), but positive diagnosis is
Externí odkaz:
https://doaj.org/article/5d7fdee08f9a40f0a8fc5ec46501e838
Autor:
Tuxiong Huang, Shan Li, Guangchao Li, Yuan Tian, Haiying Wang, Lianfa Shi, Gregorio Perez-Cordon, Li Mao, Xiaoning Wang, Jufang Wang, Hanping Feng
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110826 (2014)
Clostridium difficile toxin B (TcdB) is a key virulence factor of bacterium and induces intestinal inflammatory disease. Because of its potent cytotoxic and proinflammatory activities, we investigated the utility of TcdB in developing anti-tumor immu
Externí odkaz:
https://doaj.org/article/e983a69af4bb4af3a6802d6cd1975355
Autor:
Yongrong Zhang, Lianfa Shi, Shan Li, Zhiyong Yang, Clive Standley, Zhong Yang, Ronghua ZhuGe, Tor Savidge, Xiaoning Wang, Hanping Feng
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58634 (2013)
Clostridium difficile toxin B (TcdB) intoxicates target cells by glucosylating Rho GTPases. TcdB (269 kDa) consists of at least 4 functional domains including a glucosyltransferase domain (GTD), a cysteine protease domain (CPD), a translocation domai
Externí odkaz:
https://doaj.org/article/1ab62a8271c4463bbc5cc25f0128fb52
Autor:
Lianfa Shi, Hua Yu, Zhiyong Yang, Hanping Feng, Shan Li, Ashley Saint Fleur, Yongrong Zhang, Rosangela Salerno-Goncalves
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 611-625 (2018)
Background & Aims: Clostridium difficile toxin A (TcdA) and C difficile toxin toxin B (TcdB), the major virulence factors of the bacterium, cause intestinal tissue damage and inflammation. Although the 2 toxins are homologous and share a similar doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f07468b0bd387a21f65a1cd803318ca
https://doi.org/10.1016/j.jcmgh.2018.01.022
https://doi.org/10.1016/j.jcmgh.2018.01.022
Publikováno v:
Bioelectrochemistry. 101:153-158
This work presents a sandwich-type electrochemical impedance immunosensor for detecting Clostridium difficile toxin A (TcdA) and toxin B (TcdB). Single domain antibody conjugated gold nanoparticles were applied to amplify the detection signal. Gold n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f3f671ac5e511950c128c61866eed1
https://doi.org/10.1016/j.bioelechem.2014.10.003
https://doi.org/10.1016/j.bioelechem.2014.10.003
Autor:
Yongrong, Zhang, Shan, Li, Zhiyong, Yang, Lianfa, Shi, Hua, Yu, Rosangela, Salerno-Goncalves, Ashley, Saint Fleur, Hanping, Feng
Publikováno v:
Cellular and molecular gastroenterology and hepatology. 5(4)
Here, we investigated toxin domain functions that regulate the proinflammatory activity ofBlocking autoprocessing of TcdB by mutagenesis or chemical inhibition, while reducing cytotoxicity of the toxin, significantly enhanced its proinflammatory acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::86b0e2fe1c39b737d321d6492a5f00d8
https://pubmed.ncbi.nlm.nih.gov/29930981
https://pubmed.ncbi.nlm.nih.gov/29930981
Publikováno v:
Pathogens and Disease. 67:11-18
Clostridium difficile virulence requires secretion of two exotoxins: TcdA and TcdB. The precise mechanism of toxin uptake and delivery is undefined, but current models predict that the cysteine protease domain (CPD)-mediated autocleavage and release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261c039983de180e41c059862ea4dab8
https://doi.org/10.1111/2049-632x.12016
https://doi.org/10.1111/2049-632x.12016
Autor:
Lianfa Shi, Guang Bai, Kevin Chen, Ashley Saint Fleur, Hua Yu, Yongrong Zhang, Zhiyong Yang, Hanping Feng
Clostridium difficile infection (CDI) is the most common cause of antibiotic associated diarrhea and colitis in developed countries. The disease is mainly mediated via two major exotoxins TcdA and TcdB secreted by the bacterium. We have previously de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8fe8320ad8bcbb24c6057c3306e616
https://europepmc.org/articles/PMC5985491/
https://europepmc.org/articles/PMC5985491/
Autor:
Charalabos Pothoulakis, Kausar Ali, Hanping Feng, Tor C. Savidge, Michael J. Loeffelholz, Robert D. English, Alfredo G. Torres, Jonathan S. Stamler, Lianfa Shi, Bo Herman, Numan Oezguen, Raj Kumar, Alfred Hausladen, Weijia Nie, John E. Wiktorowicz, Vinay Acharya, Werner Braun, Petri Urvil, Iryna V Pinchuk, Aproteem Choudhury
Publikováno v:
Nature Medicine. 17:1136-1141
The global prevalence of severe Clostridium difficile infection highlights the profound clinical significance of clostridial glucosylating toxins1–4. Virulence is dependent on the autoactivation of a toxin cysteine protease5–9, which is promoted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32c97b2fd51c82f80bbf892ac2d24b9
https://doi.org/10.1038/nm.2405
https://doi.org/10.1038/nm.2405