Výsledky vyhledávání - "Lianet Vazquez"

Eliminating Cervical Cancer: A Role for Artificial Intelligence

Autor: Lynette Menezes, Charurut Somboonwit, Chilukuri K. Mohan, Lianet Vazquez

Publikováno v: Global Virology III: Virology in the 21st Century ISBN: 9783030290214

Cervical cancer caused by infection with the human papillomavirus (HPV), is the leading cause of mortality among women in many low-resource countries and the fourth leading cause of mortality globally. Decades of cervical cytology screening with subs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b923136c89f4b08b395345f852d89d5
https://doi.org/10.1007/978-3-030-29022-1_13

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HIV and Injection Drug Use: New Approaches to HIV Prevention

Autor: Charurut Somboonwit, Lynette Menezes, Lianet Vazquez

Publikováno v: Global Virology III: Virology in the 21st Century ISBN: 9783030290214

Injection drug use has become a major public health problem. Its emerging significance is demonstrated globally in the dual HIV and HCV epidemics among people who inject drugs (PWID). Despite the advent of effective antivirals against HIV and HCV, PW

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac1d4e1fee111e3a7ab3877c6fa5c369
https://doi.org/10.1007/978-3-030-29022-1_14

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The Opposing Roles of Histone Deacetylase 10 (HDAC10) and HDAC11 in Proliferation/ Survival of Mantle Cell Lymphoma (MCL) and Chronic Lymphocytic Leukemia (CLL)

Autor: Sahakian, Eva, Bijal D. Shah, Powers, John, Deng, Susan, Merino, Oscar, Ajaypal S. Gill, Rock-Klotz, Jennifer, Karrune V. Woan, Lianet Vazquez, Hongwei Wang, Chen-Kiang, Selina, Jianguo Tao, Villagra, Alejandro, Pinilla-Ibarz, Javier, Sotomayor, Eduardo M.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6b6c29f98914cc3e5fd6263089004fb

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Abstract 3555: Histone deacetylase 6 as a novel regulator of the immunogenicity and aggressiveness of melanoma

Publikováno v: Cancer Research. 72:3555-3555

Melanoma is currently the fastest growing cancer in incidence according to the World Health Organization. Currently, few therapies provide significant prolongation of survival for metastatic melanoma. Immunotherapy is an attractive modality with pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5405f85b68e9220bba62a7d339dd037c
https://doi.org/10.1158/1538-7445.am2012-3555

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Abstract 3554: The histone deacetylase inhibitor LBH589 augments anti-tumor immunity through direct effects on tumor and immune cells leading to impaired tumor progression in vivo

Autor: Eva Sahakian, Maritza Lienlaf, Javier Pinilla-Ibarz, Peter Atadja, John Powers, Merino Oscar, Jennifer Rock-Klotz, Eduardo M. Sotomayor, Zi Wang, Alejandro Villagra, David M. Woods, Edward Seto, Patricio Perez, Lianet Vazquez, Karrune Woan, Susan Deng, Hongwei Wang, Jeffrey S. Weber, Fengdong Cheng

Publikováno v: Cancer Research. 72:3554-3554

Overcoming immune tolerance is critical for the development of effective immunotherapy against cancer. Tumor cells induce tolerance through a variety of modalities including the secretion of IL-10 and TGF-β, the expression of inhibitory ligands, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5d51f711fd72cf69a4827020f2204f7
https://doi.org/10.1158/1538-7445.am2012-3554

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Histone Deacetylase 11 (HDAC11) Is a Regulatory Checkpoint of T-Cell Function: Implications for T-Cell Adoptive Immunotherapy

Publikováno v: ResearcherID

Abstract 359FN2 T-cells are an essential component of immune mediated tumor rejection. Adoptive transfer of T-cells has resulted in durable antitumor responses in some patients with hematologic malignancies. Further improvement in the efficacy of thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d3c2096897d09c7ccc6ba9854824bf
https://doi.org/10.1182/blood.v118.21.359.359

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Targeting Histone Deacetylase 6 (HDAC6) as a Novel Approach to Overcome T-Cell Anergy

Autor: Eduardo M. Sotomayor, Zi Wang, Jennifer Rock-Klotz, Ajay Gill, Danay Marante, Fengdong Cheng, Alejandro Villagra, Javier Pinilla-Ibarz, Karrune Woan, Oscar Merino, Hongwei Wang, Edward Seto, Lianet Vazquez

Publikováno v: Blood. 116:1483-1483

Abstract 1483 The anti-inflammatory molecules IL-10 and STAT3 are major hurdles in our efforts to harness effective anti-tumor immunity1. Previously, we have unveiled a role for histone deacetylase 11 (HDAC11) as a negative regulator of IL-10 gene tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85fced37e380696dff4b621edc84a175
https://doi.org/10.1182/blood.v116.21.1483.1483

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Epigenetic Modulation of STAT3 by Histone Deacetylase 6 (HDAC6) Regulates IL-10 Gene Expression and Immune Tolerance Mediated by Antigen-Presenting Cells (APCs)

Autor: Javier Pinilla, Ajaypal S. Gill, Danay Marante, Wayne W. Hancock, Rongxiang Han, Eva Sahakian, Alejandro Villagra, Fengdong Cheng, Jennifer Rock Klotz, Eduardo M. Sotomayor, Zi Wang, Liqing Wang, John Powers, Oscar Merino, Karrune Woan, Susan Deng, Hongwei Wang, Lianet Vazquez, Edward Seto

Publikováno v: ResearcherID

Abstract 519 We have previously shown that the pan-HDAC inhibitors LAQ824 and LBH589 inhibit IL-10 production in APCs, rendering these cells more inflammatory and capable of effectively priming naïve antigen-specific CD4+ T-cells and restoring the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a1fe38b8d5625101f730f15a70688f
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000299597100520&KeyUID=WOS:000299597100520

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The Opposing Role of Histone Deacetylase 10 (HDAC10) and HDAC11 in Proliferation/Survival of Mantle Cell Lymphoma (MCL) and Chronic Lymphocytic Leukemia (CLL)

Autor: Oscar Merino, Bijal D. Shah, Jianguo Tao, Javier Pinilla-Ibarz, Alejandro Villagra, Selina Chen-Kiang, John Powers, Jennifer Rock-Klotz, Ajaypal S. Gill, Eva Sahakian, Eduardo M. Sotomayor, Karrune Woan, Lianet Vazquez, Hongwei Wang, Susan Deng

Publikováno v: ResearcherID

Abstract 1363 The role of HDACs in cell biology, initially limited to their effects upon histones, encompasses now more complex regulatory functions that are dependent on their tissue expression, cellular compartment distribution and the stage of cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fabdf5a3810cc195247bb5e4014495
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000299597101632&KeyUID=WOS:000299597101632

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