Výsledky vyhledávání - "Liane M McGlynn"

Akademický článek

SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients.

Autor: Liane M McGlynn, Simon McCluney, Nigel B Jamieson, Jackie Thomson, Alasdair I MacDonald, Karin Oien, Euan J Dickson, C Ross Carter, Colin J McKay, Paul G Shiels

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0131344 (2015)

The sirtuin gene family has been linked with tumourigenesis, in both a tumour promoter and suppressor capacity. Information regarding the function of sirtuins in pancreatic cancer is sparse and equivocal. We undertook a novel study investigating SIRT

Externí odkaz: https://doaj.org/article/8273598e05554560a83e1781d238c0ff

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Akademický článek

Pre-transplant CDKN2A expression in kidney biopsies predicts renal function and is a future component of donor scoring criteria.

Autor: Marc Gingell-Littlejohn, Dagmara McGuinness, Liane M McGlynn, David Kingsmore, Karen S Stevenson, Christian Koppelstaetter, Marc J Clancy, Paul G Shiels

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e68133 (2013)

CDKN2A is a proven and validated biomarker of ageing which acts as an off switch for cell proliferation. We have demonstrated previously that CDKN2A is the most robust and the strongest pre-transplant predictor of post-transplant serum creatinine whe

Externí odkaz: https://doaj.org/article/3ef271291be14a149c6d063ccc18c9a1

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Akademický článek

Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 Study.

Autor: Tony Robertson, G David Batty, Geoff Der, Michael J Green, Liane M McGlynn, Alan McIntyre, Paul G Shiels, Michaela Benzeval

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41805 (2012)

Lower socioeconomic status (SES) is strongly associated with an increased risk of morbidity and premature mortality, but it is not known if the same is true for telomere length, a marker often used to assess biological ageing. The West of Scotland Tw

Externí odkaz: https://doaj.org/article/2abb5a2c189949279851c74c5826cf24

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Akademický článek

Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort.

Autor: Paul G Shiels, Liane M McGlynn, Alan MacIntyre, Paul C D Johnson, G David Batty, Harry Burns, Jonathan Cavanagh, Kevin A Deans, Ian Ford, Alex McConnachie, Agnes McGinty, Jennifer S McLean, Keith Millar, Naveed Sattar, Carol Tannahill, Yoga N Velupillai, Chris J Packard

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e22521 (2011)

It has previously been hypothesized that lower socio-economic status can accelerate biological ageing, and predispose to early onset of disease. This study investigated the association of socio-economic and lifestyle factors, as well as traditional a

Externí odkaz: https://doaj.org/article/8496f7f55821490cb33b0ae42eee5f8e

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Data from Ras/Raf-1/MAPK Pathway Mediates Response to Tamoxifen but not Chemotherapy in Breast Cancer Patients

Autor: Timothy G. Cooke, John M.S. Bartlett, Chris Twelves, David Cameron, Sian Tovey, Joanne Edwards, Tove Kirkegaard, Liane M. McGlynn

Purpose: The expression and activation of the Ras/Raf-1/mitogen-activated protein kinase (MAPK) pathway plays an important role in the development and progression of cancer, and may influence response to treatments such as tamoxifen and chemotherapy.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c5fef9d0122ea1ae17cbe6fa95fc83
https://doi.org/10.1158/1078-0432.c.6517500

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Supplementary Data from Ras/Raf-1/MAPK Pathway Mediates Response to Tamoxifen but not Chemotherapy in Breast Cancer Patients

Autor: Timothy G. Cooke, John M.S. Bartlett, Chris Twelves, David Cameron, Sian Tovey, Joanne Edwards, Tove Kirkegaard, Liane M. McGlynn

Supplementary Data from Ras/Raf-1/MAPK Pathway Mediates Response to Tamoxifen but not Chemotherapy in Breast Cancer Patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43cd9665bce97054735da3dfa805f72f
https://doi.org/10.1158/1078-0432.22440129

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Association between exposure to second-hand smoke and telomere length: cross-sectional study of 1303 non-smokers

Autor: Jill P. Pell, C. Johnman, L. Lu, Liane M. McGlynn, Paul G. Shiels, Daniel F. Mackay

Background: \ud Both active smoking and second-hand smoke (SHS) are important risk factors for many age-related diseases. Active smoking is associated with shortened telomere length. However, whether SHS accelerates telomere attrition with age is unc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e500058a2182a6d79e45a22708dafe
https://eprints.gla.ac.uk/150168/7/150168.pdf

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Reproducibility of telomere length assessment: an international collaborative study

Publikováno v: International Journal of Epidemiology
International Journal of Epidemiology, Oxford University Press (OUP), 2015, 44 (5), pp.1673-1683. ⟨10.1093/ije/dyu191⟩
International Journal of Epidemiology, 44(5), 1673-1683. Oxford University Press
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
International Journal of Epidemiology, Oxford University Press (OUP), 2015, 44 (5), pp.1749-1754. ⟨10.1093/ije/dyv171⟩
International Journal of Epidemiology, 2015, 44 (5), pp.1673-1683. ⟨10.1093/ije/dyu191⟩
International Journal of Epidemiology, 2015, 44 (5), pp.1749-1754. ⟨10.1093/ije/dyv171⟩

Background: Telomere length is a putative biomarker of ageing, morbidity and mortality. Its application is hampered by lack of widely applicable reference ranges and uncertainty regarding the present limits of measurement reproducibility within and b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e1d407941b583151ede2d144ea393f
http://europepmc.org/articles/PMC4681105

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