Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Liana Steeghs"'
Autor:
Sandra J van Vliet, Liana Steeghs, Sven C M Bruijns, Medi M Vaezirad, Christian Snijders Blok, Jésus A Arenas Busto, Marcel Deken, Jos P M van Putten, Yvette van Kooyk
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000625 (2009)
Gonorrhea is one of the most prevalent sexually transmitted diseases in the world. A naturally occurring variation of the terminal carbohydrates on the lipooligosaccharide (LOS) molecule correlates with altered disease states. Here, we investigated t
Externí odkaz:
https://doaj.org/article/3f6c8765689b42e58e6c4d5ffe676cf6
Autor:
Andries van Mourik, Marc M. S. M. Wösten, Jacoline van Laar, Jos P. M. van Putten, Liana Steeghs, Hendrik-Jan Hamstra, Hugo D. Meiring
Publikováno v:
Journal of Biological Chemistry. 285:15828-15836
Modification of the lipid A moiety of bacterial lipopolysaccharide influences cell wall properties, endotoxic activity, and bacterial resistance to antimicrobial peptides. Known modifications are variation in the number or length of acyl chains and/o
Autor:
Kiki Tesselaar, Peter van der Ley, Liana Steeghs, Mariëtte A. Oosterwegel, Elise H. R. Schrijver, Andries van Mourik, Miranda E.A.T. van Berkel
Publikováno v:
Vaccine. 25:4681-4688
The development of novel vaccines against Neisseria meningitidis recently gained momentum by the generation of penta-acylated lpxL1 LPS which has similar adjuvant activity, but reduced endotoxic activity as compared to hexa-acylated wild type (H44/76
Publikováno v:
Vaccine. 25:4401-4409
The adjuvant activity of Neisseria meningitidis serogroup B lipopoly(oligo)saccharide (LOS) from wild-type and genetically defined LOS mutants and unglycosylated meningococcal lipid A was assessed in C3H/HeN and C3H/HeJ mice. Meningococcal lipid A, a
Autor:
Jan Tommassen, Jeroen Geurtsen, Betsy Kuipers, Hendrik-Jan Hamstra, Alex de Haan, Jan ten Hove, Peter van der Ley, Liana Steeghs
Publikováno v:
Infection and Immunity. 74:5574-5585
Lipopolysaccharide (LPS) is one of the major constituents of the gram-negative bacterial cell envelope. Its endotoxic activity causes the relatively high reactogenicity of whole-cell vaccines. Several bacteria harbor LPS-modifying enzymes that modula
Publikováno v:
Journal of Biological Chemistry. 280:8248-8259
Lipopolysaccharide (LPS) is one of the main constituents of the Gram-negative bacterial outer membrane. It usually consists of a highly variable O-antigen, a less variable core oligosaccharide, and a highly conserved lipid moiety, designated lipid A.
Autor:
Jan Tommassen, Jeanette H. W. Leusen, Peter van der Ley, Jan G. J. van de Winkel, Liana Steeghs
Publikováno v:
Journal of Endotoxin Research. 10:113-119
The use of lipopolysaccharide (LPS) as an adjuvant is limited by its high endotoxic activity. In particular, the fatty-acyl pattern of the lipid A part of LPS has been demonstrated to determine its biological activity. By genetic modification of the
Autor:
Liana Steeghs, Garth Dixon, Heli Uronen-Hansson, Simon Y. C. Wong, Peter van der Ley, Jennifer Allen, Robin E. Callard, Mohamed Osman, Nigel Klein
Publikováno v:
Cellular Microbiology. 6:625-637
Group B Neisseria meningitidis is a human pathogen, for which a universally effective vaccine is still not available. Immune responses to bacteria are initiated by dendritic cells (DC), which internalize and process bacterial antigens for presentatio
Publikováno v:
The EMBO Journal. 22:1780-1789
In Gram-negative bacteria, lipopolysaccharide and phospholipid biosynthesis takes place at the inner membrane. How the completed lipid molecules are subsequently transported to the outer membrane remains unknown. Omp85 of Neisseria meningitidis is re
Autor:
Ad L. De Jong, Liana Steeghs, Peter van der Ley, Jan Tommassen, Jan ten Hove, Mariska Berns, Loek van Alphen, Paul Roholl
Publikováno v:
Cellular Microbiology. 4:599-611
A major problem in the development of vaccines against Gram-negative bacteria is the endotoxic -activity of lipopolysaccharide (LPS), which is determined by its lipid A moiety. Nevertheless, LPS would be an interesting vaccine component because of it