Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Liana R. Stein"'
Autor:
Sherif M. Reda, Sharay E. Setti, Andrée-Anne Berthiaume, Wei Wu, Robert W. Taylor, Jewel L. Johnston, Liana R. Stein, Hans J. Moebius, Kevin J. Church
Publikováno v:
Neurotherapeutics, Vol 21, Iss 4, Pp e00350- (2024)
Positive modulation of hepatocyte growth factor (HGF) signaling may represent a promising therapeutic strategy for Alzheimer's disease (AD) based on its multimodal neurotrophic, neuroprotective, and anti-inflammatory effects addressing the complex pa
Externí odkaz:
https://doaj.org/article/ed4f01d3996e41d59c25bf132fabd839
Autor:
Andrée-Anne Berthiaume, Sherif M. Reda, Kayla N. Kleist, Sharay E. Setti, Wei Wu, Jewel L. Johnston, Robert W. Taylor, Liana R. Stein, Hans J. Moebius, Kevin J. Church
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionAmyotrophic lateral sclerosis (ALS), a progressive and fatal neurodegenerative disorder, primarily affects the motor neurons of the brain and spinal cord. Like other neurodegenerative conditions, ongoing pathological processes such as inc
Externí odkaz:
https://doaj.org/article/a6b2579ccbb941feaef6cf0c8c0fe9a4
Autor:
Daniel Kim, Gui-Qiu Yu, Lei Zhu, Liana R. Stein, Tobias E. Larsson, Kaitlyn Ho, Lennart Mucke, Lihong Zhan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Global depletion of klotho accelerates aging, whereas klotho overexpression counteracts aging-related impairments. Why klotho is expressed at much higher levels in the choroid plexus than in other brain regions is unknown. We demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0853cd098a178395539d5762760400
https://doi.org/10.1073/pnas.1808609115
https://doi.org/10.1073/pnas.1808609115
Publikováno v:
Brain Research Bulletin. 119:41-51
Nicotinamide adenine dinucleotide (NAD(+)) is an essential coenzyme/cosubstrate for many biological processes in cellular metabolism. The rate-limiting step in the major pathway of mammalian NAD(+) biosynthesis is mediated by nicotinamide phosphoribo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7d75c37b3f521993e0d2eb36be5f93
https://doi.org/10.1016/j.brainresbull.2015.10.005
https://doi.org/10.1016/j.brainresbull.2015.10.005
Autor:
Keith A. Vossel, Lennart Mucke, Praveen Taneja, Reuben Thomas, Joseph A. Knox, Biljana Djukic, Liana R. Stein, Takashi Miyamoto
Publikováno v:
Molecular neurodegeneration, vol 12, iss 1
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-19 (2017)
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-19 (2017)
Background Hyperexcitability of neuronal networks can lead to excessive release of the excitatory neurotransmitter glutamate, which in turn can cause neuronal damage by overactivating NMDA-type glutamate receptors and related signaling pathways. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9f22ba408ae1f922029592c6f6846e
https://escholarship.org/uc/item/0kv253v6
https://escholarship.org/uc/item/0kv253v6
Publikováno v:
Neuroscience. 329
Age-associated changes in cognition are mirrored by impairments in cellular models of memory and learning, such as long-term potentiation (LTP) and long-term depression (LTD). In young rodents, environmental enrichment (EE) can enhance memory, alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6b77a5f79cdd5dd587cd2bdfc30172
https://pubmed.ncbi.nlm.nih.gov/27208617
https://pubmed.ncbi.nlm.nih.gov/27208617
Publikováno v:
Brain and Behavior
Introduction With its preservation of cytoarchitecture and synaptic circuitry, the hippocampal slice preparation has been a critical tool for studying the electrophysiological effects of pharmacological and genetic manipulations. To analyze the maxim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3327df449d47b99ebb1ef1979ec58208
https://doi.org/10.1002/brb3.736
https://doi.org/10.1002/brb3.736
Autor:
Liana R. Stein, Shin-ichiro Imai
Publikováno v:
Trends in endocrinology and metabolism: TEM. 23(9)
Mitochondria are intracellular powerhouses that produce ATP and carry out diverse functions for cellular energy metabolism. Although the maintenance of an optimal NAD/NADH ratio is essential for mitochondrial function, it has recently become apparent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754356c99f49ce7e807d586e9d891bc5
https://pubmed.ncbi.nlm.nih.gov/22819213
https://pubmed.ncbi.nlm.nih.gov/22819213
Publikováno v:
Histone Deacetylases: the Biology and Clinical Implication ISBN: 9783642216305
Ever since the discovery of sirtuins a decade ago, interest in this family of NAD-dependent deacetylases has exploded, generating multiple lines of evidence implicating sirtuins as evolutionarily conserved regulators of lifespan. In mammals, it has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a338d6c71da1f100b8740b96e02113
https://doi.org/10.1007/978-3-642-21631-2_7
https://doi.org/10.1007/978-3-642-21631-2_7