Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Liana Oganesian"'
Autor:
Daniel H. Lackner, Geneviève Almouzni, Roderick J. O'Sullivan, Armelle Corpet, Jan Karlseder, Nausica Arnoult, Candy Haggblom, Liana Oganesian
Publikováno v:
Nature Structural & Molecular Biology; Vol 21
Nature structural & molecular biology
Nature structural & molecular biology
The mechanism of activation of the alternative lengthening of telomeres (ALT) pathway of mammalian chromosome-end maintenance has been unclear. We have now discovered that co-depletion of the histone chaperones ASF1a and ASF1b in human cells induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3190821e6f1b724979d7f032e1def1
https://doi.org/10.1038/nsmb.2754
https://doi.org/10.1038/nsmb.2754
Autor:
Jan Karlseder, Liana Oganesian
Publikováno v:
DNA Repair. 12:238-245
A subset of human tumors ensures indefinite telomere length maintenance by activating a telomerase-independent mechanism known as Alternative Lengthening of Telomeres (ALT). Most tumor cells of ALT origin share a constellation of unique characteristi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f2c53a390a83f9573bf3419690f5ea
https://doi.org/10.1016/j.dnarep.2012.12.008
https://doi.org/10.1016/j.dnarep.2012.12.008
Autor:
Jan Karlseder, Liana Oganesian
Publikováno v:
Molecular Cell. 42:224-236
Recent evidence for 5'-cytosine (C)-rich overhangs at the telomeres of the nematode Caenorhabditis elegans provided the impetus to re-examine the end structure of mammalian telomeres. Two-dimensional (2D) gel electrophoresis, single telomere-length a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9991aca0a7ec5edd5eb06f62d01999
https://doi.org/10.1016/j.molcel.2011.03.015
https://doi.org/10.1016/j.molcel.2011.03.015
Autor:
Jan Karlseder, Liana Oganesian
Publikováno v:
Journal of Cell Science. 122:4013-4025
The linear nature of eukaryotic chromosomes necessitates protection of their physical ends, the telomeres, because the DNA-repair machinery can misconstrue the ends as double-stranded DNA breaks. Thus, protection is crucial for avoiding an unwarrante
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205b8abf3231a0f15680298a35d5c38b
https://doi.org/10.1242/jcs.050567
https://doi.org/10.1242/jcs.050567
Publikováno v:
Biochemistry. 46:11279-11290
Telomeric DNA can assemble into a nonlinear, higher-order conformation known as a G-quadruplex. Here, we demonstrate by electrospray ionization mass spectrometry that the two repeat telomeric sequence d(TGGGGTTGGGGT) from Tetrahymena thermophila give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88bdd3f7d725f6ec3477af0d7479ee53
https://doi.org/10.1021/bi700993q
https://doi.org/10.1021/bi700993q
Autor:
Christopher J. Jolly, Pearly Harumal, Adam Cook, Liana Oganesian, Robert Brink, Antony Basten
Publikováno v:
The Journal of Immunology. 171:6556-6564
Deoxyribonucleic acid double-stranded breaks act as intermediates in Ig V(D)J recombination and probably perform a similar function in class switch recombination between IgH C genes. In SCID mice, V(D)J recombination is blocked because the DNA-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5334e998d77b5ad7e67ef1f10794d5cb
https://doi.org/10.4049/jimmunol.171.12.6556
https://doi.org/10.4049/jimmunol.171.12.6556
Autor:
Liana Oganesian, Tracy M. Bryan
Publikováno v:
BioEssays : news and reviews in molecular, cellular and developmental biology. 29(2)
The concept of a G-quartet, a unique structural arrangement intrinsic to guanine-rich DNA, was first introduced by Gellert and colleagues over 40 years ago. For decades, it has been uncertain whether the G-quartet and the structure that it gives rise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d20e1eee0f789a39205c7212434639
https://pubmed.ncbi.nlm.nih.gov/17226803
https://pubmed.ncbi.nlm.nih.gov/17226803
Telomeric DNA can fold into four-stranded structures known as G-quadruplexes. Here we investigate the ability of G-quadruplex DNA to serve as a substrate for recombinant Tetrahymena and native Euplotes telomerase. Inter- and intramolecular G-quadrupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::262bd910388b35e8c256ae220395a617
