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Autor: Liana Gynn

Publikováno v: British Journal of Haematology. 193:46-76

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a8a9982cb9ecbb5701fa5b952f2d058
https://doi.org/10.1111/bjh.17491

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Abstracts of the Molecular Epidemiology Group (MEG-UK) Annual Conference on 'Prediction & Causal Pathways Towards Disease – What Can Molecular Markers Tell Us?', 12th March 2019, Bristol, United Kingdom

Autor: Jennifer E. May, Gareth M. Robinson, Liana Gynn, Elizabeth Anderson

Publikováno v: Mutagenesis. 34:e1-e9

Resistance to therapy remains one of the greatest challenges in the management of the blood and bone marrow (BM) disorder, acute myeloid leukaemia (AML). This study aimed to investigate how leukaemic and BM stromal cells contribute to altered chemo-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41ca320da695cb7708fa6e918b70da57
https://doi.org/10.1093/mutage/gez025

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Primary mesenchymal stromal cells in co-culture with leukaemic HL-60 cells are sensitised to cytarabine-induced genotoxicity, while leukaemic cells are protected

Autor: Jennifer E. May, Gareth M. Robinson, Elizabeth Anderson, Sarah Wexler, Liana Gynn, Christine Cox, Gillian Upstill-Goddard

Publikováno v: Mutagenesis

Tumour microenvironments are hallmarked in many cancer types. In haematological malignancies, bone marrow (BM) mesenchymal stromal cells (MSC) protect malignant cells from drug-induced cytotoxicity. However, less is known about malignant impact on su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1a025caa7fb6714433c9c5b077534e
https://pubmed.ncbi.nlm.nih.gov/34505878

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Chemotherapy-induced genotoxic damage to bone marrow cells: long-term implications

Autor: H. Ruth Morse, Jennifer E. May, Craig Donaldson, Liana Gynn

Publikováno v: Mutagenesis. 33(3)

Mesenchymal stem/stromal cells (MSCs) within the bone marrow (BM) are vitally important in forming the micro-environment supporting haematopoiesis after myeloablative chemotherapy. MSCs are known to be damaged phenotypically and functionally by chemo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a590adab73638ae93171774845d21a19
https://pubmed.ncbi.nlm.nih.gov/30239865

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Influence of Bone Marrow Stromal and Leukemic Cells on Cytarabine Chemo-Toxicity in Acute Myeloid Leukemia (AML)

Autor: Jennifer E. May, Sarah Wexler, Christine Cox, Gareth M. Robinson, Liana Gynn, Gillian Upstill-Goddard, Rhys G. Morgan, Elizabeth Anderson

Publikováno v: Blood. 134:2492-2492

Mesenchymal stromal cells (MSC) are known to protect leukemic cells from drug-induced toxicity within the bone marrow (BM) niche, however, less is known about leukemic impact on supportive MSC. The nucleoside-analogue, cytarabine (Ara-C), is a front-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b58cca94cb78b11ebe5960cb8a120ae
https://doi.org/10.1182/blood-2019-122891

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Interaction between leukaemic cells and the bone marrow stroma

Autor: Liana Gynn

Publikováno v: Liana Gynn

Mesenchymal stromal cells (MSC) enhance growth and protect leukaemic cells from drug-induced toxicity in the bone marrow microenvironment (BMM), however, these interactions are not fully understood and less is known about the impact of leukaemic cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0da8f37798cd4a00943f9471ccc6db93

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