Výsledky vyhledávání - "Liana Asatryan"

Akademický článek

Dihydromyricetin supplementation improves ethanol-induced lipid accumulation and inflammation

Autor: Isis Janilkarn-Urena, Alina Idrissova, Mindy Zhang, Masha VanDreal, Neysa Sanghavi, Samantha G. Skinner, Sydney Cheng, Zeyu Zhang, Junji Watanabe, Liana Asatryan, Enrique Cadenas, Daryl L. Davies

Publikováno v: Frontiers in Nutrition, Vol 10 (2023)

IntroductionExcessive alcohol consumption leads to a myriad of detrimental health effects, including alcohol-associated liver disease (ALD). Unfortunately, no available treatments exist to combat the progression of ALD beyond corticosteroid administr

Externí odkaz: https://doaj.org/article/43b05a15be58428cb3c8b05b39b0f5e2

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Akademický článek

Sodium Butyrate Supplementation Modulates Neuroinflammatory Response Aggravated by Antibiotic Treatment in a Mouse Model of Binge-like Ethanol Drinking

Autor: Lei Gao, Daryl L. Davies, Liana Asatryan

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 24, p 15688 (2022)

Growing evidence supports the pivotal role of the bidirectional interplay between the gut microbiota and the central nervous system during the progression of alcohol use disorder (AUD). In our previous study, supplementation with sodium butyrate (SB)

Externí odkaz: https://doaj.org/article/f24fe727cfbb4a18b4902c63e9db57ac

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Akademický článek

Dopamine Receptor Blockade Attenuates Purinergic P2X4 Receptor-Mediated Prepulse Inhibition Deficits and Underlying Molecular Mechanisms

Autor: Sheraz Khoja, Liana Asatryan, Michael W. Jakowec, Daryl L. Davies

Publikováno v: Frontiers in Cellular Neuroscience, Vol 13 (2019)

Sensorimotor gating refers to the ability to filter incoming sensory information in a stimulus-laden environment and disruption of this physiological process has been documented in psychiatric disorders characterized by cognitive aberrations. The eff

Externí odkaz: https://doaj.org/article/7af9f77245f244c784f365af02ad4f68

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Akademický článek

Cross-Talk between P2X and NMDA Receptors

Autor: Larry Rodriguez, Catherine Yi, Cameron Chu, Quentin Duriez, Sharyse Watanabe, Megan Ryu, Brandon Reyes, Liana Asatryan, Eric Boué-Grabot, Daryl Davies

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 19, p 7187 (2020)

Purinergic P2X receptors (P2X) are ATP-gated ion channels widely expressed in the CNS. While the direct contribution of P2X to synaptic transmission is uncertain, P2X reportedly affect N-methyl-D-aspartate receptor (NMDAR) activity, which has given r

Externí odkaz: https://doaj.org/article/0883cb97c5424925bd9845ac1169a6c8

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Akademický článek

Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity

Autor: Maya Popova, Larry Rodriguez, James R. Trudell, Sylvia Nguyen, Michael Bloomfield, Daryl L. Davies, Liana Asatryan

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 7, p 2471 (2020)

Mouse models of alcohol use disorder (AUD) revealed purinergic P2X4 receptors (P2X4Rs) as a promising target for AUD drug development. We have previously demonstrated that residues at the transmembrane (TM)–ectodomain interface and within the TM1 s

Externí odkaz: https://doaj.org/article/44c1e0fddd7a4697bf9c5e35e6209c15

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Akademický článek

Autor: Gohar Hakobyan, Hasmik Davtyan, Kristine Harutyunyan, Knarik Alexanyan, Yelizaveta Amirkhanyan, Anna L. Gharibyan, Liana Asatryan, Yuri Tadevosyan

Publikováno v: Medical Sciences, Vol 6, Iss 4, p 105 (2018)

Phospholipids (PLs), key elements of cellular membranes, are regulated reciprocally with membrane proteins and can act as sensors for alterations in physiological or pathological states of cells including initiation and development of cancer. On the

Externí odkaz: https://doaj.org/article/675974b50d1e4741938a12b34d1fbb71

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Akademický článek

LDL phospholipid hydrolysis produces modified electronegative particles with an unfolded apoB-100 protein

Autor: Liana Asatryan, Ryan T. Hamilton, J. Mario Isas, Juliana Hwang, Rakez Kayed, Alex Sevanian

Publikováno v: Journal of Lipid Research, Vol 46, Iss 1, Pp 115-122 (2005)

Electronegative low density lipoprotein (LDL−) formation that structurally resembles LDL− isolated from plasma was evaluated after LDL treatment with snake venom phospholipase A2 (PLA2). PLA2 treatment of LDL increased its electrophoretic mobilit

Externí odkaz: https://doaj.org/article/379201de77ee44d4867ae78585b878a0

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A novel pharmacotherapy approach using P-glycoprotein (PGP/ABCB1) efflux inhibitor combined with ivermectin to reduce alcohol drinking and preference in mice

Autor: Liana Asatryan, Sheraz Khoja, Eunjoo Pacifici, Daryl L. Davies, Joshua Silva

Publikováno v: Alcohol

Alcohol use disorder (AUD) has a major national impact, affecting over 18 million people, causing approximately 88,000 deaths, and costing upward of $250 billion annually in the United States. Unfortunately, FDA-approved AUD pharmaceuticals are few,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe4ca3ffad65149746e6086b1cd921a
https://doi.org/10.1016/j.alcohol.2020.03.013

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Cross-Talk between P2X and NMDA Receptors

Autor: Daryl L. Davies, Larry Rodriguez, Quentin Duriez, Eric Boué-Grabot, Catherine Yi, Brandon Reyes, Megan Ryu, Sharyse Watanabe, Cameron Chu, Liana Asatryan

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 19
International Journal of Molecular Sciences, Vol 21, Iss 7187, p 7187 (2020)
International Journal of Molecular Sciences, MDPI, 2020, 21 (19), pp.7187. ⟨10.3390/ijms21197187⟩

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba880aa56e77e0ca8818654e79d52c4a

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