Zobrazeno 1 - 10
of 282
pro vyhledávání: '"Lian-wen Qi"'
Autor:
Xiao-Meng Sun, Xin Wu, Meng-Guang Wei, Li-Zeng Zhu, Wen-hui Wu, Xin-Yue Zhou, Lian-Wen Qi, Qun Liu
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Elevated glucagon levels are a characteristic feature of type 2 diabetes. This abnormal increase in glucagon can lead to an accelerated rate of gluconeogenesis. Glucagon also stimulates hepatic metabolism of amino acids, particularly pr
Externí odkaz:
https://doaj.org/article/bcea602d6555461d845a44a1ac46f4cb
MLXIPL associated with tumor-infiltrating CD8+ T cells is involved in poor prostate cancer prognosis
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionWithin tumor microenvironment, the presence of preexisting antitumor CD8+ T Q7 cells have been shown to be associated with a favorable prognosis in most solid cancers. However, in the case of prostate cancer (PCa), they have been linked t
Externí odkaz:
https://doaj.org/article/488dcae83392466bbe8afa842006e201
Publikováno v:
Cardiovascular Therapeutics, Vol 2024 (2024)
Patients with stable coronary artery disease (CAD) are at an increased risk of acute myocardial infarction (AMI), particularly among older individuals. Developing a reliable model to predict AMI occurrence in these patients holds the potential to exp
Externí odkaz:
https://doaj.org/article/e7fc5ecfad0644c5b9ac790d21e2adcb
Autor:
Qian-Qian Chen, Kang Liu, Ning Shi, Gaoxiang Ma, Peipei Wang, Hua-Mei Xie, Si-Jia Jin, Ting-Ting Wei, Xiang-Yu Yu, Yi Wang, Jun-Yuan Zhang, Ping Li, Lian-Wen Qi, Lei Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
The influenza virus neuraminidase has been well documented, yet the functions of mammalian neuraminidases remain less explored. Here, the authors show that neuraminidase 1 promotes renal fibrosis development by interacting with ALK5 to activate SMAD2
Externí odkaz:
https://doaj.org/article/21ac961131cf4726ace833594b60ef32
Autor:
Yi-Jing Zhao, Yangyang Sun, Fan Wang, Yuan-Yuan Cai, Raphael N. Alolga, Lian-Wen Qi, Pingxi Xiao
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundResults from randomized controlled trials (RCTs) and meta-analyses comparing invasive and conservative strategies in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) are highly debatable. We systematically evaluate the effi
Externí odkaz:
https://doaj.org/article/b6d84e91f6914a77b71b311f71cf0cc6
Publikováno v:
Cell Death and Disease, Vol 13, Iss 9, Pp 1-15 (2022)
Abstract Oxidative stress is a vital contributor to the development and progression of diabetes-accelerated atherosclerosis. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a well-known molecule that participates in cellular defense against oxi
Externí odkaz:
https://doaj.org/article/b1aba21faf484ff3b46c70e7cc550bb0
Autor:
Yuan-Yuan Cai, Feng-Qing Huang, Xingzhen Lao, Yawen Lu, Xuejiao Gao, Raphael N. Alolga, Kunpeng Yin, Xingchen Zhou, Yun Wang, Baolin Liu, Jing Shang, Lian-Wen Qi, Jing Li
Publikováno v:
npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Microbial trimethylamine (TMA)-lyase activity promotes the development of atherosclerosis by generating of TMA, the precursor of TMA N-oxide (TMAO). TMAO is well documented, but same can not be said of TMA-producing bacteria. This work aimed
Externí odkaz:
https://doaj.org/article/111dd78d10ac4548a42a4a91d30777cc
Autor:
An Pan, Xiao-Meng Sun, Feng-Qing Huang, Jin-Feng Liu, Yuan-Yuan Cai, Xin Wu, Raphael N. Alolga, Ping Li, Bao-Lin Liu, Qun Liu, Lian-Wen Qi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Disordered hepatic glucagon response contributes to hyperglycemia in diabetes via gluconeogenesis. Here the authors report that the mitochondrial β-oxidation enzyme HADHA promotes β-hydroxybutyrate production, which negatively regulates hepatic glu
Externí odkaz:
https://doaj.org/article/c496981c96274b57bdb3e44d07d72876
Autor:
Rongrong Zhou, Cristina Llorente, Jinling Cao, Livia S. Zaramela, Suling Zeng, Bei Gao, Shang-Zhen Li, Ryan D. Welch, Feng-Qing Huang, Lian-Wen Qi, Chuyue Pan, Yan Huang, Pengchen Zhou, Iris Beussen, Ying Zhang, Gregory Bryam, Oliver Fiehn, Lirui Wang, E-Hu Liu, Ruth T. Yu, Michael Downes, Ronald M. Evans, Karrie Goglin, Derrick E. Fouts, David A. Brenner, Lars Bode, Xuegong Fan, Karsten Zengler, Bernd Schnabl
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 293-320 (2021)
Background & Aims: Fucosyltransferase 2 (Fut2)-mediated intestinal α1- 2-fucosylation is important for host–microbe interactions and has been associated with several diseases, but its role in obesity and hepatic steatohepatitis is not known. The a
Externí odkaz:
https://doaj.org/article/5af44eddfde74e05a6ad638356662629
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The liver plays an important role in glucose and lipid homeostasis, drug metabolism, and bile synthesis. Metabolic disorder and inflammation synergistically contribute to the pathogenesis of numerous liver diseases, such as metabolic-associated fatty
Externí odkaz:
https://doaj.org/article/d3e081bd3df34575a430b0177ee2220f