Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Lian Quan Gu"'
Publikováno v:
Molecules, Vol 14, Iss 4, Pp 1546-1560 (2009)
Six 3-methylpyridine zwitterions and six quinoline zwitterions were synthesized through the reaction of 4-hydroxycoumarins, p-benzoquinone and the corresponding N-aromatics. The novel pseudo-cyclic face-to-face rigid structure of the zwitterion was e
Externí odkaz:
https://doaj.org/article/993147e378884b0cac0c07cadd685a37
Autor:
Lin-Kun An, Lian-Quan Gu, Teng-Wei Zhu, Jian-Wen Chen, Le-Mao Yu, Qian Yu, Zhi-Shu Huang, Hui Yang
Publikováno v:
European Journal of Medicinal Chemistry. 152:195-207
Our previous studies reveal that indolizinoquinolinedione scaffold is a base to develop novel DNA topoisomerase IB (TOP1) catalytic inhibitors. In this work, twenty-three novel indolizinoquinolinedione derivatives were synthesized. TOP1-mediated rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22f4064f31c75a0170e356d8b3d5b3d
https://doi.org/10.1016/j.ejmech.2018.04.040
https://doi.org/10.1016/j.ejmech.2018.04.040
Publikováno v:
Journal of Molecular Structure. 1154:1-7
Design of small molecules targeted at human telomeric G-quadruplex DNA is an extremely active research area. Interestingly, the telomeric G-quadruplex is a highly polymorphic structure. Changes in its conformation upon small molecule binding may be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4da404649799ad93f586c9b124e4a0f
https://doi.org/10.1016/j.molstruc.2017.09.114
https://doi.org/10.1016/j.molstruc.2017.09.114
Publikováno v:
Acta Crystallographica Section E, Vol 64, Iss 3, Pp o593-o593 (2008)
The title disubstituted naphthalene-1,4-dione, C24H16Cl2O2, has the two chlorobenzyl substituents related by a non-crystallographic twofold rotation axis, generating a chiral conformation; both enantiomers are present. The two chlorobenzene rings are
Externí odkaz:
https://doaj.org/article/090aa5f9a0cb42d98d2efb7ab80f72b9
Autor:
Lian-Quan Gu, Guo-Tao Kuang, Zhi-Shu Huang, De-Ying Zeng, Ding Li, Yan Zhang, Jiaojiao Cao, Jia-Heng Tan, Bing Shu, Tian-Miao Ou, Mingxue Wang
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1861:3246-3256
Background Telomeric repeat–containing RNA (TERRA) is a large non-coding RNA in mammalian cells, which forms an integral component of telomeric heterochromatin. TERRA can bind to an allosteric site of telomeric repeat factor 2 (TRF2), a key compone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7507b94ddb5c35ae0382ebcf3ba53770
https://doi.org/10.1016/j.bbagen.2017.09.015
https://doi.org/10.1016/j.bbagen.2017.09.015
Autor:
Zhi-Shu Huang, Sheng Yin, Tian-Miao Ou, Mingxue Wang, Lian-Quan Gu, Yan Zhang, Jun Qiu, Jia-Heng Tan, Bing Shu, Jian-Yong Zhu, Jiaojiao Cao, Ding Li
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1865:1372-1382
Telomeric repeat factor 2 (known as TRF2 or TERF2) is a key component of telomere protection protein complex named as Shelterin. TRF2 helps the folding of telomere to form T-loop structure and the suppression of ATM-dependent DNA damage response acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709b5c27ebd08aab04d07de97f33a8f7
https://doi.org/10.1016/j.bbapap.2017.08.022
https://doi.org/10.1016/j.bbapap.2017.08.022
Autor:
Zhi-Shu Huang, Lian-Quan Gu, Yu-Qing Wang, Jia-Heng Tan, Chan Shan, Qi-Kun Yin, Chen-Xi Wang, Tian-Miao Ou, Ding Li, Zhou-Li Huang, Shuo-Bin Chen
Publikováno v:
Journal of Medicinal Chemistry. 60:6924-6941
c-MYC is one of the important human proto-oncogenes, and transcriptional factor NM23-H2 can activate c-MYC transcription by recognizing the G-quadruplex in the promoter of the gene. Small molecules that inhibit c-MYC transcription by disrupting the N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375f52ad0409d1893dcdc1ee29bedb95
https://doi.org/10.1021/acs.jmedchem.7b00421
https://doi.org/10.1021/acs.jmedchem.7b00421
Autor:
Zhi-Shu Huang, Yong Rao, Zhao Xu, Lian-Quan Gu, Yu-Ting Lu, Ji-Ming Ye, Hong Yu, Hong Liu, Gao Lin
Publikováno v:
British Journal of Pharmacology. 174:2457-2470
Background and purpose Promoting energy metabolism is known to provide therapeutic effects for obesity and associated metabolic disorders. The present study evaluated the therapeutic effects of the newly identified bouchardatine (Bou) on obesity-asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db6e8f54c1df66a336503d916dcdf882
https://doi.org/10.1111/bph.13855
https://doi.org/10.1111/bph.13855
Autor:
Lian-Quan Gu, Qi Zhang, Shi-Ke Wang, Wang Peng, Zhi-Shu Huang, Xiao-Xuan Su, Tian-Miao Ou, Guo-Tao Kuang, De-Ying Zeng, Ming-Hao Hu, Shu-Ling Lin, Honggen Wang, Jia-Heng Tan
Publikováno v:
Journal of Medicinal Chemistry. 60:5407-5423
The specificity of nucleic acids' binders is crucial for developing this kind of drug, especially for novel G-quadruplexes' binders. Quindoline derivatives have been developed as G-quadruplex stabilizers with good interactive activities. In order to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f2f50bb605f3d16a0dc4bd609b5b65
https://doi.org/10.1021/acs.jmedchem.7b00016
https://doi.org/10.1021/acs.jmedchem.7b00016
Autor:
Zhi-Shu Huang, Gao Lin, Yu-Tao Hu, Ji-Ming Ye, Yu-Ting Lu, Hong Yu, Chan Li, Zhao Xu, Lian-Quan Gu, Yao-Hao Xu, Yong Rao, Qin-Qin Song
Publikováno v:
Br J Pharmacol
Background and purpose Non-alcoholic hepatic fatty liver disease (NAFLD) is a manifestation of the metabolic syndrome in the liver and non-alcoholic steatohepatitis (NASH) represents its advanced stage. R17 derived from bouchardatine, shows benefits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8149b1989c3d7f46a72bbd8f4829dc3
https://europepmc.org/articles/PMC6637044/
https://europepmc.org/articles/PMC6637044/
