Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Lian Qiu Wu"'
Autor:
Li Xiang, Hai-Lin Qin, Song Huachen, An-Jun Deng, Yufei Wang, Wen-Jie Wang, Hai-Jing Zhang, Lian-Qiu Wu, Tang Xiaonan
Publikováno v:
Drug Design, Development and Therapy. 14:4291-4302
Introduction Colitis-associated cancer (CAC) accounts for approximately 15% of IBD patient mortalities. However, currently available anti-CAC drugs possess many disadvantages including safety, specificity and side effects. Therefore, the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae9b050254cf3a86ff64eef04022ae33
https://doi.org/10.2147/dddt.s262806
https://doi.org/10.2147/dddt.s262806
Autor:
Lian-Qiu Wu, Changwei Chai, Tang Xiaonan, Hai-Jing Zhang, Yufei Wang, Zhehui Zhao, Li Xiang, Ying Peng
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that affects 1% of the population. CS-semi5 is a semisynthetic chondroitin sulfate. In this study, CS-semi5 was shown to have positive effects on a model of collagen-induced arthriti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fcd2f495e7b4bb88fa6661355f74e7
https://doi.org/10.3389/fphar.2021.655101
https://doi.org/10.3389/fphar.2021.655101
Publikováno v:
Journal of Asian natural products research. 24(4)
In order to obtain new dihydrocoptisine-type compounds with stable structure and activating XBP1 transcriptional activity, (±)-8-trifluoromethyldihydrocoptisine derivatives as target compounds were synthesized from quaternary ammonium chlorides of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f031b6ff2d68c327f285e555800952bf
https://pubmed.ncbi.nlm.nih.gov/34132154
https://pubmed.ncbi.nlm.nih.gov/34132154
Publikováno v:
Chemistry & Biodiversity. 17
13-[(N-Alkylamino)methyl]-8-oxodihydrocoptisines were synthesized to evaluate antibacterial activity against Clostridium difficile and activating x-box-binding protein 1 (XBP1) activity, biological properties both associated with ulcerative colitis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a495b84e423d0f3d1f161767812a45e1
https://doi.org/10.1002/cbdv.202000265
https://doi.org/10.1002/cbdv.202000265
Autor:
Lei Guo, Wen-juan Wu, Long-ding Liu, Li-chun Wang, Ying Zhang, Lian-qiu Wu, Ying Guan, Qi-han Li
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45749 (2012)
ICP22 is a multifunctional herpes simplex virus 1 (HSV-1) immediate early protein that functions as a general repressor of a subset of cellular and viral promoters in transient expression systems. Although the exact mechanism of repression remains un
Externí odkaz:
https://doaj.org/article/b14daa7f479c4025b7579139dad2d5f9
Autor:
Song Li, Sheng-Qi Wang, Li Xiang, Zhi-Hong Li, An-Jun Deng, Zhi-Hui Zhang, Jia Li, Hai-Lin Qin, Lian-Qiu Wu, Hai-Jing Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:2586-2598
In this study, quaternary palmatine is used as a lead compound to design and synthesize derivatives to evaluate bioactivities, with twenty-seven compounds of four series being obtained. Antibacterial activity was examined by determining the minimal i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387ae4b0337715ddbaeab7298571e0c3
https://doi.org/10.1016/j.bmc.2018.04.025
https://doi.org/10.1016/j.bmc.2018.04.025
Autor:
Hai-Lin Qin, Zhi-Hui Zhang, An-Jun Deng, GuangMing Song, Song Huachen, Wen-Jie Wang, Hai-Jing Zhang, Tang Xiaonan, Lian-Qiu Wu
Publikováno v:
European Journal of Pharmaceutical Sciences. 109:56-64
There is a severe lack of effective treatments for ulcerative colitis (UC), a recurrent and intractable inflammatory bowel disease. The identification of valid targets and new drugs is an urgent need. In this study, we identified the XBP-1 agonist HL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7237a20df1f270120ba2c44698f2792
https://doi.org/10.1016/j.ejps.2017.07.028
https://doi.org/10.1016/j.ejps.2017.07.028
Autor:
An-Jun Deng, Tang Xiaonan, Hai-Lin Qin, Lian-Qiu Wu, Li Xiang, Wen-Jie Wang, Hai-Jing Zhang, Yufei Wang, Zhi-Hui Zhang
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
Frontiers in Pharmacology
Frontiers in Pharmacology
Ulcerative colitis (UC) is a refractory chronic disease characterized by bloody diarrhea and mucosal or submucosal ulcers. There is an urgent need of new drugs for the treatment of ulcerative colitis. EHLJ7 is a quaternary coptisine derivative. Herei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c023a89bdc572595c1c353ea21a72f3
https://pubmed.ncbi.nlm.nih.gov/32038241
https://pubmed.ncbi.nlm.nih.gov/32038241
Publikováno v:
International Immunopharmacology. 32:16-23
Pain greatly affects the quality of life of people worldwide. Despite their demonstrated efficacy, currently used opioid drugs and nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently associated with several adverse events. The identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209b51009c42901610b316bd8a240b6e
https://doi.org/10.1016/j.intimp.2016.01.004
https://doi.org/10.1016/j.intimp.2016.01.004
Autor:
Ya-Lun Su, Jin Ren, Yan-Gai Wang, Hai-Lin Qin, Wen-Jie Wang, Hai-Jing Zhang, Lian-Qiu Wu, Ai-Guo Wang
Publikováno v:
Journal of Natural Products. 78:2322-2331
Eight new cembranoids, boscartins A-H (1, 2, and 4-9), and the known incensole oxide were isolated from the gum resin of Boswellia carterii. The absolute configurations of 1, 2, 4, and incensole oxide were unequivocally resolved using single-crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86ff09494c69bb8fde5d52b6511ffc3
https://doi.org/10.1021/acs.jnatprod.5b00104
https://doi.org/10.1021/acs.jnatprod.5b00104