Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lian N Lee"'
Autor:
Matheswaran Kandasamy, Uzi Gileadi, Pramila Rijal, Tiong Kit Tan, Lian N Lee, Jili Chen, Gennaro Prota, Paul Klenerman, Alain Townsend, Vincenzo Cerundolo
Publikováno v:
eLife, Vol 12 (2023)
Virus-based tumour vaccines offer many advantages compared to other antigen-delivering systems. They generate concerted innate and adaptive immune response, and robust CD8+ T cell responses. We engineered a non-replicating pseudotyped influenza virus
Externí odkaz:
https://doaj.org/article/19381c4da57642bb86445baca9176ae3
Autor:
Suzanne van Duikeren, Frits Koning, Hideo Yagita, Esmé TI van der Gracht, Mark JA Schoonderwoerd, Ayse N Yilmaz, Felix M Behr, Julia M Colston, Lian N Lee, Klaas PJM van Gisbergen, Lukas JAC Hawinkels
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Adenoviral vectors emerged as important platforms for cancer immunotherapy. Vaccination with adenoviral vectors is promising in this respect, however, their specific mechanisms of action are not fully understood. Here, we assessed the deve
Externí odkaz:
https://doaj.org/article/bd16e214200248758bc30b48ab6f26d4
Autor:
Lian N Lee, Beatrice Bolinger, Zoltan Banki, Catherine de Lara, Andrew J Highton, Julia M Colston, Claire Hutchings, Paul Klenerman
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006782 (2017)
The efficacies of many new T cell vaccines rely on generating large populations of long-lived pathogen-specific effector memory CD8 T cells. However, it is now increasingly recognized that prior infection history impacts on the host immune response.
Externí odkaz:
https://doaj.org/article/626b9d0344c24ca4baf49288d6449eb8
Autor:
Iryna Dekhtiarenko, Robert B Ratts, Renata Blatnik, Lian N Lee, Sonja Fischer, Lisa Borkner, Jennifer D Oduro, Thomas F Marandu, Stephanie Hoppe, Zsolt Ruzsics, Julia K Sonnemann, Mandana Mansouri, Christine Meyer, Niels A W Lemmermann, Rafaela Holtappels, Ramon Arens, Paul Klenerman, Klaus Früh, Matthias J Reddehase, Angelika B Riemer, Luka Cicin-Sain
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006072 (2016)
Cytomegalovirus (CMV) elicits long-term T-cell immunity of unparalleled strength, which has allowed the development of highly protective CMV-based vaccine vectors. Counterintuitively, experimental vaccines encoding a single MHC-I restricted epitope o
Externí odkaz:
https://doaj.org/article/9a787b2030704af9add09bb205309a6b
Autor:
Eleanor Gaunt, Helen M Wise, Huayu Zhang, Lian N Lee, Nicky J Atkinson, Marlynne Quigg Nicol, Andrew J Highton, Paul Klenerman, Philippa M Beard, Bernadette M Dutia, Paul Digard, Peter Simmonds
Publikováno v:
eLife, Vol 5 (2016)
Previously, we demonstrated that frequencies of CpG and UpA dinucleotides profoundly influence the replication ability of echovirus 7 (Tulloch et al., 2014). Here, we show that that influenza A virus (IAV) with maximised frequencies of these dinucleo
Externí odkaz:
https://doaj.org/article/28937b5695ef427589e8844caadf5f30
Autor:
Matheswaran Kandasamy, Uzi Gileadi, Pramila Rijal, Tiong Kit Tan, Lian N Lee, Jili Chen, Gennaro Prota, Paul Klenerman, Alain Townsend, Vincenzo Cerundolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::031d5fd05f2ebc1f69a41a232d83f6c9
https://doi.org/10.7554/elife.76414.sa2
https://doi.org/10.7554/elife.76414.sa2
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, 9
Frontiers in Immunology
Frontiers in Immunology, 9
Frontiers in Immunology
For many years, the focus of prophylactic vaccines was to elicit neutralizing antibodies, but it has become increasingly evident that T cell-mediated immunity plays a central role in controlling persistent viral infections such as with human immunode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c52920680f8426008ca2483da8db83
https://doi.org/10.3389/fimmu.2018.00276
https://doi.org/10.3389/fimmu.2018.00276