Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Lian Lam"'
Publikováno v:
Engineering, Vol 5, Iss 1, Pp 115-121 (2019)
Forkhead box P3 (FOXP3) is a “master regulator” of regulatory T cells (Tregs), which are a subset of T cells that can suppress the antigen-specific immune reaction and that play important roles in host tolerance and immune homeostasis. It is well
Externí odkaz:
https://doaj.org/article/16960d25cb554d91abafb611080bd808
Publikováno v:
Antibodies, Vol 10, Iss 3, p 32 (2021)
The lack of progress in developing targeted therapeutics directed at protein–protein complexes has been due to the absence of well-defined ligand-binding pockets and the extensive intermolecular contacts at the protein–protein interface. Our labo
Externí odkaz:
https://doaj.org/article/491de3547c4b445795002bcab4ecdd3e
Autor:
Krithika N. Kodumudi, Ganesan Ramamoorthi, Colin Snyder, Amrita Basu, Yongsheng Jia, Sabrina Awshah, Amber P. Beyer, Doris Wiener, Lian Lam, Hongtao Zhang, Mark I. Greene, Ricardo L. B. Costa, Brian J. Czerniecki
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Patients with metastatic HER2 breast cancer (MBC) often become resistant to HER 2 targeted therapy and have recurrence of disease. The Panacea trial suggested that HER2 MBC patients were more likely to respond to checkpoint therapy if TIL were presen
Externí odkaz:
https://doaj.org/article/0030af4bce4f4c24a0cb50d21063b785
Publikováno v:
OncoImmunology, Vol 7, Iss 4 (2018)
Despite substantial clinical progress with targeted therapies, current antibody-based approaches have limited efficacy at controlling HER2/neu-positive breast cancers, especially in the absence of chemotherapies. Previously, we showed that the combin
Externí odkaz:
https://doaj.org/article/37acd3fa99bc436caf396fbf34731539
Supplementary Figure S1 PDF file 1270K, Structural model of Fc�R - IgG Fc - domain B triple complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bfbb67823452c9082ae13b3f26eac58
https://doi.org/10.1158/0008-5472.22398435
https://doi.org/10.1158/0008-5472.22398435
Supplementary Information PDF file - 77K, Additional information on the HER2 Domain 4 sequence, methods and figure legends for supplemental figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8a0755b035485a9a17c332b39b02bc
https://doi.org/10.1158/0008-5472.22398423
https://doi.org/10.1158/0008-5472.22398423
Recruitment of immune cells to tumor cells targeted by a therapeutic antibody can heighten the antitumor efficacy of the antibody. For example, p185her2/neu-targeting antibodies not only downregulate the p185her2/neu kinase (ERBB2) but also trigger c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f7d17433533b598d3d7cdc1811359d
https://doi.org/10.1158/0008-5472.c.6505068
https://doi.org/10.1158/0008-5472.c.6505068
Autor:
Zhiqiang Zhu, Peeyush N. Goel, Cai Zheng, Yasuhiro Nagai, Lian Lam, Arabinda Samanta, Meiqing Ji, Hongtao Zhang, Mark I. Greene
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 7; Pages: 6477
Our laboratory has identified and developed a unique human-engineered domain (HED) structure that was obtained from the human Alpha-2-macroglobulin receptor-associated protein based on the three-dimensional structure of the Z-domain derived from Stap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb97489f498aeb72d96542a8350fb9d
https://doi.org/10.3390/ijms24076477
https://doi.org/10.3390/ijms24076477
Publikováno v:
Engineering, Vol 5, Iss 1, Pp 115-121 (2019)
Forkhead box P3 (FOXP3) is a “master regulator” of regulatory T cells (Tregs), which are a subset of T cells that can suppress the antigen-specific immune reaction and that play important roles in host tolerance and immune homeostasis. It is well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a119313b292bd1ec1c6e01cc2b15fab4
https://doi.org/10.1016/j.eng.2019.01.001
https://doi.org/10.1016/j.eng.2019.01.001
Publikováno v:
Antibodies
Antibodies, Vol 10, Iss 32, p 32 (2021)
Antibodies, Vol 10, Iss 32, p 32 (2021)
The lack of progress in developing targeted therapeutics directed at protein–protein complexes has been due to the absence of well-defined ligand-binding pockets and the extensive intermolecular contacts at the protein–protein interface. Our labo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b9d945c0b67764c227942f0c16ab30
https://pubmed.ncbi.nlm.nih.gov/34449551
https://pubmed.ncbi.nlm.nih.gov/34449551