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Akademický článek

HED, a Human-Engineered Domain, Confers a Unique Fc-Binding Activity to Produce a New Class of Humanized Antibody-like Molecules

Autor: Zhiqiang Zhu, Peeyush N. Goel, Cai Zheng, Yasuhiro Nagai, Lian Lam, Arabinda Samanta, Meiqing Ji, Hongtao Zhang, Mark I. Greene

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 7, p 6477 (2023)

Our laboratory has identified and developed a unique human-engineered domain (HED) structure that was obtained from the human Alpha-2-macroglobulin receptor-associated protein based on the three-dimensional structure of the Z-domain derived from Stap

Externí odkaz: https://doaj.org/article/7941ecb1e9e847fa9a18b5171c132b8a

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Akademický článek

FOXP3 and Its Cofactors as Targets of Immunotherapies

Autor: Yasuhiro Nagai, Lian Lam, Mark I. Greene, Hongtao Zhang

Publikováno v: Engineering, Vol 5, Iss 1, Pp 115-121 (2019)

Forkhead box P3 (FOXP3) is a “master regulator” of regulatory T cells (Tregs), which are a subset of T cells that can suppress the antigen-specific immune reaction and that play important roles in host tolerance and immune homeostasis. It is well

Externí odkaz: https://doaj.org/article/16960d25cb554d91abafb611080bd808

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Akademický článek

Rational Design of Constrained Peptides as Protein Interface Inhibitors

Autor: Ramachandran Murali, Hongtao Zhang, Zheng Cai, Lian Lam, Mark Greene

Publikováno v: Antibodies, Vol 10, Iss 3, p 32 (2021)

The lack of progress in developing targeted therapeutics directed at protein–protein complexes has been due to the absence of well-defined ligand-binding pockets and the extensive intermolecular contacts at the protein–protein interface. Our labo

Externí odkaz: https://doaj.org/article/491de3547c4b445795002bcab4ecdd3e

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Akademický článek

Sequential Anti-PD1 Therapy Following Dendritic Cell Vaccination Improves Survival in a HER2 Mammary Carcinoma Model and Identifies a Critical Role for CD4 T Cells in Mediating the Response

Autor: Krithika N. Kodumudi, Ganesan Ramamoorthi, Colin Snyder, Amrita Basu, Yongsheng Jia, Sabrina Awshah, Amber P. Beyer, Doris Wiener, Lian Lam, Hongtao Zhang, Mark I. Greene, Ricardo L. B. Costa, Brian J. Czerniecki

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Patients with metastatic HER2 breast cancer (MBC) often become resistant to HER 2 targeted therapy and have recurrence of disease. The Panacea trial suggested that HER2 MBC patients were more likely to respond to checkpoint therapy if TIL were presen

Externí odkaz: https://doaj.org/article/0030af4bce4f4c24a0cb50d21063b785

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Akademický článek

A targeted immunotherapy approach for HER2/neu transformed tumors by coupling an engineered effector domain with interferon-γ

Autor: Hongtao Zhang, Lian Lam, Yasuhiro Nagai, Zhiqiang Zhu, Xi Chen, Mei Q. Ji, Mark I. Greene

Publikováno v: OncoImmunology, Vol 7, Iss 4 (2018)

Despite substantial clinical progress with targeted therapies, current antibody-based approaches have limited efficacy at controlling HER2/neu-positive breast cancers, especially in the absence of chemotherapies. Previously, we showed that the combin

Externí odkaz: https://doaj.org/article/37acd3fa99bc436caf396fbf34731539

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Supplementary Information from scFv-Based 'Grababody' as a General Strategy to Improve Recruitment of Immune Effector Cells to Antibody-Targeted Tumors

Autor: Hongtao Zhang, Zhiqiang Zhu, Marla Yee, Lian Lam, Yasuhiro Nagai, Ting Fu, Zheng Cai

Supplementary Information PDF file - 77K, Additional information on the HER2 Domain 4 sequence, methods and figure legends for supplemental figures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8a0755b035485a9a17c332b39b02bc
https://doi.org/10.1158/0008-5472.22398423

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Supplementary Figure S3 from scFv-Based 'Grababody' as a General Strategy to Improve Recruitment of Immune Effector Cells to Antibody-Targeted Tumors

Autor: Hongtao Zhang, Zhiqiang Zhu, Marla Yee, Lian Lam, Yasuhiro Nagai, Ting Fu, Zheng Cai

Supplementary Figure S3 PDF file 1739K, Binding of antibodies to D4(508-577) by SPR analysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6220862d426cccb80d8f11ccf7a31730
https://doi.org/10.1158/0008-5472.22398429

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Data from scFv-Based 'Grababody' as a General Strategy to Improve Recruitment of Immune Effector Cells to Antibody-Targeted Tumors

Autor: Hongtao Zhang, Zhiqiang Zhu, Marla Yee, Lian Lam, Yasuhiro Nagai, Ting Fu, Zheng Cai

Recruitment of immune cells to tumor cells targeted by a therapeutic antibody can heighten the antitumor efficacy of the antibody. For example, p185her2/neu-targeting antibodies not only downregulate the p185her2/neu kinase (ERBB2) but also trigger c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f7d17433533b598d3d7cdc1811359d
https://doi.org/10.1158/0008-5472.c.6505068

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