Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lian Gelis"'
Autor:
Nikolina Jovancevic, Soumaya Khalfaoui, Markus Weinrich, Daniel Weidinger, Annika Simon, Benjamin Kalbe, Marcus Kernt, Anselm Kampik, Günter Gisselmann, Lian Gelis, Hanns Hatt
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
The odorant receptor 51E2 (OR51E2), which is well-characterized in prostate cancer cells and epidermal pigment cells, was identified for the first time as the most highly expressed OR in human fetal and adult retinal pigment epithelial (RPE) cells. I
Externí odkaz:
https://doaj.org/article/0a7a313a7e4c469ea7ab991b30682417
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182147 (2017)
We performed an analysis of possible mechanisms of ligand recognition in the human nose. The analysis is based on in vivo odor threshold determination and in vitro Ca2+ imaging assays with a C/Si/Ge/Sn switch strategy applied to the compounds Lilial
Externí odkaz:
https://doaj.org/article/73daa9ba41f049c887074c07d51d0c87
Publikováno v:
Therapeutic Innovation & Regulatory Science.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47fad17492c493772ed017f86b65072a
https://doi.org/10.1007/s43441-023-00535-z
https://doi.org/10.1007/s43441-023-00535-z
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
We analysed the ligand-based activation mechanism of the prostate-specific G-protein coupled receptor (PSGR), which is an olfactory receptor that mediates cellular growth in prostate cancer cells. Furthermore, it is an olfactory receptor with a known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8d400c5d77b2f56b21c57fd22e5ce0
http://link.springer.com/article/10.1038/s41598-017-16001-4
http://link.springer.com/article/10.1038/s41598-017-16001-4
Autor:
Christian Becker, Anne Offermann, Annika Simon, Hanns Hatt, Katarina Luko, Markus Heiland, Janine Altmüller, Nikolina Jovancevic, Aria Baniahmad, Günter Gisselmann, Thanakorn Pungsrinont, Sven Perner, Lian Gelis, Stathis Philippou, Lea Weber, Désirée Maßberg, Burkhard Ubrig
Publikováno v:
Oncotarget
The development of prostate cancer (PCa) is regulated by the androgen-dependent activity of the androgen receptor (AR). Androgen-deprivation therapy (ADT) is therefore the gold standard treatment to suppress malignant progression of PCa. Nevertheless
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f6e2525d0b72111dec1b6fd3dba15d
http://europepmc.org/articles/PMC5217014
http://europepmc.org/articles/PMC5217014
Publikováno v:
Experimental dermatology. 26(7)
We identified the olfactory receptor 51E2 in human melanoma and have measured both OR51E2 mRNA and protein expression in melanoma tissue sections. qPCR analysis revealed that the receptor is upregulated in melanoma cells compared to normal melanocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5b3cba23ac41a6110bc51447666873
https://pubmed.ncbi.nlm.nih.gov/28191688
https://pubmed.ncbi.nlm.nih.gov/28191688
Autor:
Andreas Dendorfer, Filomain Nguemo, E. Schleicher, Matthias Matzkies, M. Boehm, Lea Weber, Juergen Hescheler, Judith Semmler, Nikolina Jovancevic, Markus Osterloh, Hanns Hatt, Lian Gelis, Hendrik Milting, J. C. Heckmann, M. Kovarova
Publikováno v:
Basic Research in Cardiology
Several studies have demonstrated the expression of odorant receptors (OR) in various human tissues and their involvement in different physiological and pathophysiological processes. However, the functional role of ORs in the human heart is still unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8e8d7217feb93c05e722b993cea0c6
https://doi.org/10.1007/s00395-017-0600-y
https://doi.org/10.1007/s00395-017-0600-y
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 8, p e0182147 (2017)
PLoS ONE, Vol 12, Iss 8, p e0182147 (2017)
We performed an analysis of possible mechanisms of ligand recognition in the human nose. The analysis is based on in vivo odor threshold determination and in vitro Ca2+ imaging assays with a C/Si/Ge/Sn switch strategy applied to the compounds Lilial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e33426d0b8f5f488bbb074a20f1dc3
https://pubmed.ncbi.nlm.nih.gov/28763484
https://pubmed.ncbi.nlm.nih.gov/28763484
Autor:
Lian Gelis, Hanns Hatt, Bhubaneswar Mandal, Sophie Veitinger, Nikolina Jovancevic, Hans-Dieter Arndt, Eva M. Neuhaus
Olfactory receptors, which belong to the family of G-protein-coupled receptors, are found to be ectopically expressed in non-sensory tissues mediating a variety of cellular functions. In this study we detected the olfactory receptor OR51E2 at the tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d290c592d88d285481b086e962ee1aa4
https://europepmc.org/articles/PMC5016170/
https://europepmc.org/articles/PMC5016170/
Publikováno v:
Angewandte Chemie. 124:1300-1304
Das Riechsystem von S ugetieren nutzt eine grose Familie von G-Protein-gekoppelten Rezeptoren (GPCRs), um eine Vielzahl fl chtiger Liganden zu erkennen und zu unterscheiden. Mehr als 350 menschliche Gene kodieren funktionale olfaktorische Rezeptoren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e66fe66620dddda431a002eef78501f0
https://doi.org/10.1002/ange.201103980
https://doi.org/10.1002/ange.201103980