Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Liam T Martin"'
C-1 Substituted isoquinolines potentiate the antimycobacterial activity of rifampicin and ethambutol
Autor:
Liam T. Martin, Eleanor D. Lamming, Arundhati Maitra, Parisa N. Mortazavi, Rebecca Roddan, John M. Ward, Sanjib Bhakta, Helen C. Hailes
Publikováno v:
Frontiers in Antibiotics, Vol 2 (2023)
IntroductionThe emergence of extensively drug-resistant strains of Mycobacterium tuberculosis threatens decades of progress in the treatment of a disease which remains one of the leading infectious causes of death worldwide. The development of novel
Externí odkaz:
https://doaj.org/article/b19c3d06f60449e4b8617a588c56b3ec
Autor:
Aidan Hanrath, Timothy D. McHugh, Marc Lipman, Helen C. Hailes, Simon J. Waddell, Ellie Chapman, Dimitrios Evangelopoulos, Alina Chrzastek, Arundhati Maitra, Sanjib Bhakta, Liam T Martin
Publikováno v:
Journal of Antimicrobial Chemotherapy
BackgroundThe rise of antimicrobial drug resistance in Mycobacterium tuberculosis coupled with the shortage of new antibiotics has elevated TB to a major global health priority. Repurposing drugs developed or used for other conditions has gained spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540cf211bf8e0687eda8dfbecb44f48d
http://europepmc.org/articles/PMC7566368
http://europepmc.org/articles/PMC7566368
Autor:
Antima Gupta, Adrian J. Shepherd, Syamasundari Nukala, Kristine B. Arnvig, Arundhati Maitra, Alethea B. Tabor, Rachael Dickman, Sanjib Bhakta, Nicholas H. Keep, Liam T Martin, Tulika Munshi
Publikováno v:
JAC-Antimicrobial Resistance
Objectives Identification and validation of novel therapeutic targets is imperative to tackle the rise of drug resistance in tuberculosis. An essential Mur ligase-like gene (Rv3712), expected to be involved in cell-wall peptidoglycan (PG) biogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce131c363316c2de6aa08095dbf5e43f
https://doi.org/10.1093/jacamr/dlab028
https://doi.org/10.1093/jacamr/dlab028
Autor:
Olaf Kunert, Julia Solnier, Tri Minh Le, Eva-Maria Pferschy-Wenzig, Huyen Thi Tran, Franz Bucar, Sanjib Bhakta, Liam T Martin, Rudolf Bauer, Loi Huynh
Publikováno v:
Antibiotics, Vol 9, Iss 390, p 390 (2020)
Antibiotics
Volume 9
Issue 7
Antibiotics
Volume 9
Issue 7
Carvotacetones (1&ndash
7) isolated from Sphaeranthus africanus were screened for their antimycobacterial and efflux pump (EP) inhibitory potential against the mycobacterial model strains Mycobacterium smegmatis mc2 155, Mycobacterium aurum ATCC
7) isolated from Sphaeranthus africanus were screened for their antimycobacterial and efflux pump (EP) inhibitory potential against the mycobacterial model strains Mycobacterium smegmatis mc2 155, Mycobacterium aurum ATCC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bda36df751cfbf61afed94e067bf4c
https://www.mdpi.com/2079-6382/9/7/390
https://www.mdpi.com/2079-6382/9/7/390
Autor:
Charlotte E, Coomber, Victor, Laserna, Liam T, Martin, Peter D, Smith, Helen C, Hailes, Michael J, Porter, Tom D, Sheppard
Publikováno v:
Organic & Biomolecular Chemistry
B(OCH2CF3)3-catalysed direct amidations of challenging substrates (polar heteroycles, poorly nucleophilic anilines) work well in tBuOAc under Dean–Stark conditions.
Catalytic direct amidation reactions have been the focus of considerable recen
Catalytic direct amidation reactions have been the focus of considerable recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44b0a4f852f102a57e82403dc477a3fb
https://pubmed.ncbi.nlm.nih.gov/31225568
https://pubmed.ncbi.nlm.nih.gov/31225568
Autor:
Michael J. Porter, Helen C. Hailes, Charlotte E. Coomber, Tom D. Sheppard, Peter D. Smith, Victor Laserna, Liam T Martin
Catalytic direct amidation reactions have been the focus of considerable recent research effort, due to the widespread use of amide formation processes in pharmaceutical synthesis. However, the vast majority of catalytic amidations are performed in n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40a0bddf9138fe2ea0b93aefa18a4fec
https://doi.org/10.26434/chemrxiv.8068703.v1
https://doi.org/10.26434/chemrxiv.8068703.v1
Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles' heel for the TB-causing pathogen
Autor:
Arundhati, Maitra, Tulika, Munshi, Jess, Healy, Liam T, Martin, Waldemar, Vollmer, Nicholas H, Keep, Sanjib, Bhakta
Publikováno v:
FEMS Microbiology Reviews
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis, remains one of the leading causes of mortality across the world. There is an urgent requirement to build a robust arsenal of effective antimicrobials, targeting novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad39912e9d3c78b1865f0d5f9181d248
https://pubmed.ncbi.nlm.nih.gov/31183501
https://pubmed.ncbi.nlm.nih.gov/31183501
Publikováno v:
Molecules
Molecules, Vol 25, Iss 3, p 734 (2020)
Volume 25
Issue 3
Molecules, Vol 25, Iss 3, p 734 (2020)
Volume 25
Issue 3
Therapeutic treatment options for opportunistic non-tuberculous mycobacterial (NTM) infection and/or serious mycobacterial infections such as tuberculosis (TB) and leprosy are limited due to the spread of antimicrobial resistance mechanism. Plant-der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18480ae962f7a07adc6888a2cb8aa1e
https://doi.org/10.3390/molecules25030734
https://doi.org/10.3390/molecules25030734