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pro vyhledávání: '"Liam S. Turk"'
Publikováno v:
European Biophysics Journal
Reelin is a secreted glycoprotein that is integral in neocortex development and synaptic function. Reelin exists as a homodimer with two chains linked by a disulfide bond at cysteine 2101, a feature that is vital to the protein’s function. This is
Publikováno v:
Biophys J
Neuronal development and function are dependent in part on the several roles of the secreted glycoprotein Reelin. Endogenous proteases process this 400 kDa, modular protein, yielding N-terminal, central, and C-terminal fragments that each have distin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1dcb72dfe6553ebf71827b06923dda5
Autor:
M Dolores, Martín-de-Saavedra, Marc, Dos Santos, Lorenza, Culotta, Olga, Varea, Benjamin P, Spielman, Euan, Parnell, Marc P, Forrest, Ruoqi, Gao, Sehyoun, Yoon, Emmarose, McCoig, Hiba A, Jalloul, Kristoffer, Myczek, Natalia, Khalatyan, Elizabeth A, Hall, Liam S, Turk, Antonio, Sanz-Clemente, Davide, Comoletti, Stefan F, Lichtenthaler, Jeffrey S, Burgdorf, Maria V, Barbolina, Jeffrey N, Savas, Peter, Penzes
Publikováno v:
Neuron
While many neuronal, membrane proteins undergo proteolytic cleavage, little is known about the biological significance of neuronal ectodomain shedding (ES). Here, we show that the neuronal sheddome is detectable in human cerebrospinal fluid (hCSF) an
Autor:
Muyuan Chen, Kevin Huynh, Michael J. Currie, Daniel Mitchell, Liam S. Turk, Renwick C. J. Dobson, Valentina Dal Pozzo, Gabriella D'Arcangelo, Xuyuan Kuang, Davide Comoletti, Khush Patel, Wei Dai
Publikováno v:
Structure (London, England : 1993). 29(10)
Reelin operates through canonical and non-canonical pathways that mediate several aspects of brain development and function. Reelin's dimeric central fragment (CF), generated through proteolytic cleavage, is required for the lipoprotein-receptor-depe
Autor:
M. Dolores Martín-de-Saavedra, Marc Dos Santos, Lorenza Culotta, Olga Varea, Benjamin P. Spielman, Euan Parnell, Marc P. Forrest, Ruoqi Gao, Sehyoun Yoon, Emmarose McCoig, Hiba A. Jalloul, Kristoffer Myczek, Natalia Khalatyan, Elizabeth A. Hall, Liam S. Turk, Antonio Sanz-Clemente, Davide Comoletti, Stefan F. Lichtenthaler, Jeffrey S. Burgdorf, Maria V. Barbolina, Jeffrey N. Savas, Peter Penzes
Publikováno v:
Neuron 110(4), 627-643.e9 (2022). doi:10.1016/j.neuron.2021.11.025
Although many neuronal membrane proteins undergo proteolytic cleavage, little is known about the biological significance of neuronal ectodomain shedding (ES). Here, we show that the neuronal sheddome is detectable in human cerebrospinal fluid (hCSF)
Autor:
Laura Trobiani, Natalia G. Denissova, Engin Özkan, Antonella De Jaco, Sumie Kakehi, Gaetano T. Montelione, Sinem Ozgul, Liam S. Turk, Sventja von Daake, Nicole Lopez, Davide Comoletti, Borries Demeler, Fanomezana M. Ranaivoson
Publikováno v:
Structure (London, England : 1993). 27(6)
In the developing brain, cell-surface proteins play crucial roles, but their protein-protein interaction network remains largely unknown. A proteomic screen identified 200 interactions, 89 of which were not previously published. Among these interacti