Improving Mycobacterium bovis bacillus Calmette-Guèrin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells.

Autor: Manjunatha M Venkataswamy, Tony W Ng, Shalu S Kharkwal, Leandro J Carreño, Alison J Johnson, Shajo Kunnath-Velayudhan, Zheng Liu, Robert Bittman, Peter J Jervis, Liam R Cox, Gurdyal S Besra, Xiangshu Wen, Weiming Yuan, Moriya Tsuji, Xiangming Li, David D Ho, John Chan, Sunhee Lee, Richard Frothingham, Barton F Haynes, Michael W Panas, Geoffrey O Gillard, Jaimie D Sixsmith, Birgit Korioth-Schmitz, Joern E Schmitz, Michelle H Larsen, William R Jacobs, Steven A Porcelli

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e108383 (2014)

Recombinant Mycobacterium bovis bacillus Calmette-Guèrin (rBCG) has been explored as a vector for vaccines against HIV because of its ability to induce long lasting humoral and cell mediated immune responses. To maximize the potential for rBCG vacci

Externí odkaz: https://doaj.org/article/90e45a31ded54c5cbca2c3231d0f0e54

Influence of the Lipid Backbone on Electrochemical Phase Behavior

Autor: Philip N. Jemmett, David C. Milan, Richard J. Nichols, Thomas Howitt, Alexandra L. Martin, Thomas Arnold, Jonathan L. Rawle, Christopher L. Nicklin, Timothy R. Dafforn, Liam R. Cox, Sarah L. Horswell

Publikováno v: Langmuir. 38:14290-14301

Sphingolipids are an important class of lipids found in mammalian cell membranes with important structural and signaling roles. They differ from another major group of lipids, the glycerophospholipids, in the connection of their hydrocarbon chains to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0c2fadbdace677d6dc2234f56fe457
https://doi.org/10.1021/acs.langmuir.2c02370

Hydrogels and Bioprinting in Bone Tissue Engineering: Creating Artificial Stem‐Cell Niches for in Vitro Models

Autor: Francesca K. Lewns, Olga Tsigkou, Liam R. Cox, Ricky D. Wildman, Liam M. Grover, Gowsihan Poologasundarampillai

Publikováno v: Advanced Materials.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a2e7490f6d99f7773bf77a70612b45d
https://doi.org/10.1002/adma.202301670

Serial Stimulation of Invariant Natural Killer T Cells with Covalently Stabilized Bispecific T Cell Engagers Generates Anti-Tumor Immunity While Avoiding Anergy

Autor: Liam R. Cox, Amareeta K. Besra, Himanshu Kharkwal, Natacha Veerapen, Gurdyal S. Besra, Alan Howell, Christopher T. Johndrow, Lianjun Zhang, Noemi Alejandra Saavedra-Avila, Peter J. Jervis, Leandro J. Carreño, Elizabeth E. Evans, Steven A. Porcelli, Samantha Rothberg, Alena Donda, Steven C. Almo, Maurice Zauderer, Shalu Sharma Kharkwal, Scott J. Garforth, Jinghang Zhang

Publikováno v: Cancer Res

CD1d-restricted invariant natural killer T cells (iNKT cells) mediate strong antitumor immunity when stimulated by glycolipid agonists. However, attempts to develop effective iNKT cell agonists for clinical applications have been thwarted by potentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9e51cc5ecf1296bf2eb078435815ad
https://europepmc.org/articles/PMC8137529/

Ligand-dependent downregulation of MR1 cell surface expression

Autor: Natacha Veerapen, David M. Lewinsohn, Mariolina Salio, Anne W. J. Martens, Wael Awad, Corinna Kulicke, Claudia Gonzalez-Lopez, Vincenzo Cerundolo, Dominic Waithe, Judith V. Hobrath, Liam R. Cox, Gurdyal S. Besra, Jamie Rossjohn

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 117(19), 10465-10475. National Academy of Sciences

Significance MR1 is a monomorphic major histocompatibility complex (MHC) class I-like molecule that presents ligands to Mucosal Associated Invariant T cells. MR1 antigen presentation at the cell surface is tightly regulated by ligand availability. Al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e8ec78172338967f83c3a2ae2fb5dd