Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Liam P. Hallada"'
Autor:
C. Le Chapelain, Liam P. Hallada, Rodolfo Tello-Aburto, Doleshwar Niroula, D. Dotson, Michael Groll, S.K. Ganegamage, Snezna Rogelj
The peptidic β-lactone proteasome inhibitors (PIs) cystargolides A and B were used to conduct structure-activity relationship (SAR) studies in order to assess their anticancer potential. A total of 24 different analogs were designed, synthesized and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6037ab19d93c7edc6dd98ba94eb3d863
https://europepmc.org/articles/PMC6168434/
https://europepmc.org/articles/PMC6168434/
Publikováno v:
Tetrahedron. 73(4)
A total synthesis of the cytotoxic terpenoid hortonone C was accomplished and its absolute stereochemistry confirmed. Intermediate (+)-4 was synthesized using either an asymmetric conjugate addition strategy, or by elaboration of the Hajos-Parrish ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b19cfd1badc0c8d89b4e35e80cb8ef
https://pubmed.ncbi.nlm.nih.gov/28066031
https://pubmed.ncbi.nlm.nih.gov/28066031
Publikováno v:
Organicbiomolecular chemistry. 13(40)
The absolute stereochemistry of the cystargolides was determined by total synthesis. Evaluation of synthetic cystargolides and derivatives showed that the natural (2S,3R) stereochemistry is essential for activity. Moreover, benzyl esters (−)-10 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0029d9580e152ba4f60b9b8f472f680
https://pubmed.ncbi.nlm.nih.gov/26400369
https://pubmed.ncbi.nlm.nih.gov/26400369