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pro vyhledávání: '"Liam McCrea"'
Autor:
Ian Pitha, Siva Kambhampati, Anjali Sharma, Rishi Sharma, Liam McCrea, Ann Mozzer, Rangaramanujam M. Kannan
Publikováno v:
Biomacromolecules
Retinal microglial/macrophage activation and optic nerve (ON) microglial/macrophage activation are glaucoma biomarkers and potential therapeutic targets for this blinding disease. We report targeting of activated microglia by PAMAM dendrimers in a ra
BackgroundTheCYFIP1gene, located in the neurodevelopmental risk locus 15q11.2, is highly expressed in microglia, but its role in human microglial function as it relates to neurodevelopment is not well understood.MethodsWe generated multiple CRISPR kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95922120820bbd059c8b4e943b025ef9
https://doi.org/10.1101/2022.10.24.513576
https://doi.org/10.1101/2022.10.24.513576
Publikováno v:
Exp Eye Res
Scleral fibroblast activation occurs in glaucomatous and myopic eyes. Here we perform an unbiased screen to identify kinase inhibitors that reduce fibroblast activation to diverse stimuli in vitro and to in vivo intraocular pressure (IOP) elevation.
Autor:
Amanda Chow, Harry A. Quigley, Ian Pitha, Julia Szeto, Ann Mozzer, Liam McCrea, Thao D. Nguyen
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The purpose of this study was to describe the cellular architecture of normal human peripapillary sclera (PPS) and evaluate surface topography's role in fibroblast behavior. Methods PPS cryosections from nonglaucomatous eyes were labelled for