Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Liam James, McGuffin"'
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 12, Pp 29829-29842 (2015)
Elucidating the biological and biochemical roles of proteins, and subsequently determining their interacting partners, can be difficult and time consuming using in vitro and/or in vivo methods, and consequently the majority of newly sequenced protein
Externí odkaz:
https://doaj.org/article/720772f914174afc88e44251b7607b29
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175957 (2017)
Advances in omics technologies have led to the discovery of genetic markers, or single nucleotide polymorphisms (SNPs), that are associated with particular diseases or complex traits. Although there have been significant improvements in the approache
Externí odkaz:
https://doaj.org/article/b7fd7b59282e4fe999814b333bf8aaf4
Autor:
Recep Adiyaman, Liam James McGuffin
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2301 (2019)
The refinement of predicted 3D protein models is crucial in bringing them closer towards experimental accuracy for further computational studies. Refinement approaches can be divided into two main stages: The sampling and scoring stages. Sampling str
Externí odkaz:
https://doaj.org/article/6c5a83fadf2144a58d788732c21e6603
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 12, p 2623 (2017)
The elucidation of protein–protein interactions is vital for determining the function and action of quaternary protein structures. Here, we discuss the difficulty and importance of establishing protein quaternary structure and review in vitro and i
Externí odkaz:
https://doaj.org/article/35da9683d4024340ae3e7e4d95f21b53
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2365
Proteins are essential molecules with a diverse range of functions; elucidating their biological and biochemical characteristics can be difficult and time consuming using in vitro and/or in vivo methods. Additionally, in vivo protein-ligand binding s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5da1ae0192f78c63ff4df807bbc6d2e
https://pubmed.ncbi.nlm.nih.gov/34432238
https://pubmed.ncbi.nlm.nih.gov/34432238
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1414
Protein-ligand binding site prediction methods aim to predict, from amino acid sequence, protein-ligand interactions, putative ligands, and ligand binding site residues using either sequence information, structural information, or a combination of bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50e602c3fe939060f69bdcb6505b6510
https://pubmed.ncbi.nlm.nih.gov/27094282
https://pubmed.ncbi.nlm.nih.gov/27094282
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1369
Protein tertiary structure prediction algorithms aim to predict, from amino acid sequence, the tertiary structure of a protein. In silico protein structure prediction methods have become extremely important, as in vitro-based structural elucidation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ebdb08a2e9c6678081a7249e7ce230e
https://pubmed.ncbi.nlm.nih.gov/26519323
https://pubmed.ncbi.nlm.nih.gov/26519323
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1137
Model quality assessment programs (MQAPs) aim to assess the quality of modelled 3D protein structures. The provision of quality scores, describing both global and local (per-residue) accuracy are extremely important, as without quality scores we are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::77d8ec8f7de9be7b9e0d7e311c1c9d37
https://pubmed.ncbi.nlm.nih.gov/24573476
https://pubmed.ncbi.nlm.nih.gov/24573476
Autor:
Liam James, McGuffin
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 413
Most newly sequenced proteins are likely to adopt a similar structure to one which has already been experimentally determined. For this reason, the most successful approaches to protein structure prediction have been template-based methods. Such pred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e96b808753d0ad0d3be681d1514113c7
https://pubmed.ncbi.nlm.nih.gov/18075162
https://pubmed.ncbi.nlm.nih.gov/18075162