Výsledky vyhledávání - "Liam J. Murphy"

Prohibitin binds to C3 and enhances complement activation

Autor: Suresh Mishra, Saby Moulik, Liam J. Murphy

Publikováno v: Molecular Immunology. 44:1897-1902

Prohibitin (PHB1) is a multifunction protein that is released in lipid droplets from adipocytes and possibly other cells and is detectable in the circulation. We used crosslinking, immunoprecipitation and proteomic analysis to investigate binding par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8310f8a28ca9f4bffa99d2362b6493
https://doi.org/10.1016/j.molimm.2006.09.025

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Ethnicity, Insulin Resistance, and Inflammatory Adipokines in Women at High and Low Risk for Vascular Disease

Autor: William D. Leslie, Liam J. Murphy, B. L. Grégoire Nyomba, Josef V. Silha

Publikováno v: Diabetes Care. 30:286-291

OBJECTIVE—We sought to compare the relationship between body composition, insulin resistance, and inflammatory adipokines in Aboriginal Canadian women, who are at high risk of vascular disease, with white women. RESEARCH DESIGN AND METHODS—A subg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455d4e19e1965a41fd607bf4f010efb3
https://doi.org/10.2337/dc06-1073

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Insulin-Like Growth Factor (IGF) Binding Protein-3 Attenuates Prostate Tumor Growth by IGF-Dependent and IGF-Independent Mechanisms

Autor: Josef V. Silha, Liam J. Murphy, Patricia C. Sheppard, Suresh Mishra, Jacquie Schwartz, Janice G. Dodd, Yaoting Gui

Publikováno v: Endocrinology. 147:2112-2121

IGF binding protein (IGFBP)-3 inhibits cell growth and promotes apoptosis by sequestering free IGFs. In addition IGFBP-3 has IGF-independent, proapoptotic, antiproliferative effects on prostate cancer cells in vitro. Expression of the large T-antigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba49ab93b30dbc8b4b19a7488324447
https://doi.org/10.1210/en.2005-1270

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The Prohibitins: emerging roles in diverse functions

Autor: Suresh Mishra, Leigh C. Murphy, Liam J. Murphy

Publikováno v: Journal of Cellular and Molecular Medicine

The prohibitins, Phb1 and Phb2 are highly conserved proteins in eukaryotic cells that are present in multiple cellular compartments. Initial investigations focused on the role of Phb1 as an inhibitor of cell proliferation hence the original name proh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd54d0e8f6e3e2f3bf7c13ddb627a715
https://doi.org/10.1111/j.1582-4934.2006.tb00404.x

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Phosphorylation of Histones by Tissue Transglutaminase

Autor: Liam J. Murphy, Paula S. Espino, Suresh Mishra, Ali Saleh, James R. Davie

Publikováno v: Journal of Biological Chemistry. 281:5532-5538

Tissue transglutaminase 2 (TG2) has recently been shown to have intrinsic serine/threonine kinase activity. Since histones are known to be cross-linked by TG2, we investigated whether histones are also substrates for TG2 kinase activity. TG2 was able

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8795b04b1bb701934c9658effe9e188f
https://doi.org/10.1074/jbc.m506864200

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Angiogenic factors are elevated in overweight and obese individuals

Autor: Michal Krsek, Liam J. Murphy, P. Sucharda, Josef V. Silha

Publikováno v: International Journal of Obesity. 29:1308-1314

Adipose tissue produces both vascular growth factors and inhibitors. Since obesity is associated with expansion of the capillary bed in regional adipose depots the balance between these factors may favor angiogenesis.To investigate the relationship b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4fc5b55ccaab9150a1c9effc5960b92
https://doi.org/10.1038/sj.ijo.0802987

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Overexpression of Gly56/Gly80/Gly81-Mutant Insulin-Like Growth Factor-Binding Protein-3 in Transgenic Mice

Autor: Liam J. Murphy, Suresh Mishra, Arnold Leckstrom, Josef V. Silha, Yaoting Gui, Pinchas Cohen

Publikováno v: Endocrinology. 146:1523-1531

IGF-independent effects of IGF-binding protein-3 (IGFBP-3) have been demonstrated in vitro; however, the physiological significance of these effects in vivo is unclear. We generated two transgenic (Tg) mouse strains that overexpress a human Gly56/Gly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c3cbc2cec66ee9641300d1f48e4de7
https://doi.org/10.1210/en.2004-0905

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Orlistat: an update after the first decade of clinical experience

Autor: Liam J. Murphy

Publikováno v: Therapy. 2:7-12

Approximately a decade has pasted since the introduction of orlistat for the treatment of obesity. A considerable amount of clinical trial evidence has been accumulated to demonstrate that orlistat is safe and effective both for induction of weight l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18330d22a74c8bb7488696fd9cc9c52b
https://doi.org/10.2217/14750708.2.1.7

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The effects of insulin-like growth factor binding protein-3 (IGFBP-3) on T47D breast cancer cells enriched for IGFBP-3 binding sites

Autor: Liam J. Murphy, Suresh Mishra

Publikováno v: Molecular and Cellular Biochemistry. 267:83-89

To investigate insulin-like growth factor (IGF)-independent effects of IGF binding protein-3 (IGFBP-3), T47D cells were enriched for a population of cells that expressed binding sites for biotinylated-IGFBP-3 by panning on streptavidin-coated plate.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d697ad290adc433f3830d889e9e9e39
https://doi.org/10.1023/b:mcbi.0000049368.40558.0a

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