Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Liam E. Browne"'
Autor:
Liam E. Browne, Alban Latremoliere, Brendan P. Lehnert, Alyssa Grantham, Catherine Ward, Chloe Alexandre, Michael Costigan, Frédéric Michoud, David P. Roberson, David D. Ginty, Clifford J. Woolf
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 89-98 (2017)
Potentially harmful stimuli are detected at the skin by nociceptor sensory neurons that drive rapid protective withdrawal reflexes and pain. We set out to define, at a millisecond timescale, the relationship between the activity of these sensory neur
Externí odkaz:
https://doaj.org/article/4f4fd07e2d954e0fab68135267d19cc2
Publikováno v:
eLife, Vol 10 (2021)
Somatosensory stimuli guide and shape behavior, from immediate protective reflexes to longer-term learning and higher-order processes related to pain and touch. However, somatosensory inputs are challenging to control in awake mammals due to the dive
Externí odkaz:
https://doaj.org/article/149b30ce43e547b487c840a571072f1d
Autor:
Rachel Moon, Daniel Taub, Clifford J. Woolf, Sébastien Talbot, Liam E Browne, Michael Tetreault, Zihe Zhang, Corey R. Seehus, Noe Brun, Ivan Furfaro, Philipp Schonle, Benjamin Doyle, Katia Galan, Outman Akouissi, Aakanksha Jain, Stéphanie P. Lacour, Pascale Meier, Frédéric Michoud, Qiuting Huang
Publikováno v:
Nature biotechnology
Activation of nociceptor sensory neurons by noxious stimuli both triggers pain and increases capillary permeability and blood flow to produce neurogenic inflammation1,2, but whether nociceptors also interact with the immune system remains poorly unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ccb1a0d3076816b4e6969d6a4500a3
https://doi.org/10.1038/s41587-020-0673-2
https://doi.org/10.1038/s41587-020-0673-2
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Somatosensory stimuli guide and shape behavior, from immediate protective reflexes to longer-term learning and higher-order processes related to pain and touch. However, somatosensory inputs are challenging to control in awake mammals due to the dive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc546ed7e1c99b15a5ec5d9cf443142
https://doi.org/10.1101/2020.08.10.244046
https://doi.org/10.1101/2020.08.10.244046
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2041
This chapter details methods to express and modify ATP-gated P2X receptor channels so that they can be controlled using light. Following expression in cells, a photoswitchable tool compound can be used to covalently modify mutant P2X receptors, as pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d242c0773f471bcd8b8bfd7ea0d9edaf
https://pubmed.ncbi.nlm.nih.gov/31646498
https://pubmed.ncbi.nlm.nih.gov/31646498
Publikováno v:
Methods in Molecular Biology ISBN: 9781493997169
This chapter details methods to express and modify ATP-gated P2X receptor channels so that they can be controlled using light. Following expression in cells, a photoswitchable tool compound can be used to covalently modify mutant P2X receptors, as pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7fa31dc1f5f769bad606bf517a29cc8
https://doi.org/10.1007/978-1-4939-9717-6_22
https://doi.org/10.1007/978-1-4939-9717-6_22
Autor:
Benjamin Doyle, Clifford J. Woolf, Bruce P. Bean, Junwei Huang, David Roberson, Bruce D. Levy, Maryam Ahmadi, Simmie L. Foster, Sébastien Talbot, Liam E Browne, Jo-Chiao Wang, Ajay S. Yekkirala
Publikováno v:
J Allergy Clin Immunol
summary Airway sensory neuron-produced Substance P heightens allergy-induced goblet cell hyperplasia and hypersecretion of Muc5AC, electrically silencing these overreactive neurons reduced these components of lung type 2 allergic inflammatory respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ac01b1fdef7c9fdffe978fad021d16
https://doi.org/10.1016/j.jaci.2020.01.003
https://doi.org/10.1016/j.jaci.2020.01.003
Publikováno v:
The Journal of Biological Chemistry
Background: The ATP-gated channel (P2X2) receptor ectodomain is formed by β-strands from three subunits. Results: ATP-induced channel opening was prevented by disulfide locking between pairs of substituted cysteines in different subunits. Conclusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3aa6d60c864c049d975bd280eb78c7b
https://doi.org/10.1074/jbc.m113.542811
https://doi.org/10.1074/jbc.m113.542811
Autor:
Liam E. Browne
Publikováno v:
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 1:56-69
P2X receptors are trimeric ion channels that open in response to extracellular ATP. The publication of the first X-ray structure of a closed P2X receptor has confirmed many of the functional experiments carried out since the mid-1990s and provides a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33bc06b66c485be1c1b7b60590933319
https://doi.org/10.1002/wmts.24
https://doi.org/10.1002/wmts.24