Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Liam C. Lee"'
Autor:
Perla Pucci, Liam C. Lee, Miaojun Han, Jamie D. Matthews, Leila Jahangiri, Michaela Schlederer, Eleanor Manners, Annabel Sorby-Adams, Joshua Kaggie, Ricky M. Trigg, Christopher Steel, Lucy Hare, Emily R. James, Nina Prokoph, Stephen P. Ducray, Olaf Merkel, Firkret Rifatbegovic, Ji Luo, Sabine Taschner-Mandl, Lukas Kenner, G. A. Amos Burke, Suzanne D. Turner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Targeting Anaplastic lymphoma kinase (ALK) is a promising therapeutic strategy for aberrant ALK-expressing malignancies including neuroblastoma, but resistance to ALK tyrosine kinase inhibitors (ALK TKI) is a distinct possibility necessitati
Externí odkaz:
https://doaj.org/article/12cef060f54047bf95b2dad4e211f0d7
Autor:
Ricky M. Trigg, Liam C. Lee, Nina Prokoph, Leila Jahangiri, C. Patrick Reynolds, G. A. Amos Burke, Nicola A. Probst, Miaojun Han, Jamie D. Matthews, Hong Kai Lim, Eleanor Manners, Sonia Martinez, Joaquin Pastor, Carmen Blanco-Aparicio, Olaf Merkel, Ines Garces de los Fayos Alonso, Petra Kodajova, Simone Tangermann, Sandra Högler, Ji Luo, Lukas Kenner, Suzanne D. Turner
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Anaplastic lymphoma kinase (ALK) inhibitors are currently being considered in neuroblastoma (NB), but its acquired resistance is reported in non-small cell lung cancers. Here, the authors have found PIM1 overexpression decreases sensitivity to ALK in
Externí odkaz:
https://doaj.org/article/f2be0a65707b41b5b2ef0367cf79b3cb
Autor:
Scott W. Lowe, Frank McCormick, Ji Luo, Johannes Zuber, Joseph O. Carver, Danielle Grace, Dennis J. Hsu, Liam C. Lee, Vishal Thapar, Cayde D. Ritchie, Chih-Shia Lee, Christof Fellmann, Tina L. Yuan
Supplemental Methods from Development of siRNA Payloads to Target KRAS-Mutant Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0f77481446407f2633e4905df7600b
https://doi.org/10.1158/2159-8290.22530686.v1
https://doi.org/10.1158/2159-8290.22530686.v1
Autor:
Scott W. Lowe, Frank McCormick, Ji Luo, Johannes Zuber, Joseph O. Carver, Danielle Grace, Dennis J. Hsu, Liam C. Lee, Vishal Thapar, Cayde D. Ritchie, Chih-Shia Lee, Christof Fellmann, Tina L. Yuan
Supplemental References from Development of siRNA Payloads to Target KRAS-Mutant Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2622a69cc375264a1fd5ea964a743423
https://doi.org/10.1158/2159-8290.22530683.v1
https://doi.org/10.1158/2159-8290.22530683.v1
Autor:
Scott W. Lowe, Frank McCormick, Ji Luo, Johannes Zuber, Joseph O. Carver, Danielle Grace, Dennis J. Hsu, Liam C. Lee, Vishal Thapar, Cayde D. Ritchie, Chih-Shia Lee, Christof Fellmann, Tina L. Yuan
Supplemental Figure and Table Legends from Development of siRNA Payloads to Target KRAS-Mutant Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000f1ec7fd97bf34d90eb23fe56268f2
https://doi.org/10.1158/2159-8290.22530692
https://doi.org/10.1158/2159-8290.22530692
Supplemental Figures S1-S5, Table S1 from Development of siRNA Payloads to Target KRAS-Mutant Cancer
Autor:
Scott W. Lowe, Frank McCormick, Ji Luo, Johannes Zuber, Joseph O. Carver, Danielle Grace, Dennis J. Hsu, Liam C. Lee, Vishal Thapar, Cayde D. Ritchie, Chih-Shia Lee, Christof Fellmann, Tina L. Yuan
Supplemental Figure S1. Sensor-based generation of a functionally validated sh/siRNA library targeting Ras pathway genes. Figure S2. Validation of Sensor siRNAs targeting components in the MAPK pathway. Figure S3. Dose dependent off-target effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd48b7865b9f27fcea81f2673f43bae
https://doi.org/10.1158/2159-8290.22530689
https://doi.org/10.1158/2159-8290.22530689
Autor:
Scott W. Lowe, Frank McCormick, Ji Luo, Johannes Zuber, Joseph O. Carver, Danielle Grace, Dennis J. Hsu, Liam C. Lee, Vishal Thapar, Cayde D. Ritchie, Chih-Shia Lee, Christof Fellmann, Tina L. Yuan
Analysis of shRNA and endogenous miRNA representation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd250e4f1c00cfcc7ea105d08135dcf
https://doi.org/10.1158/2159-8290.22530677
https://doi.org/10.1158/2159-8290.22530677
Autor:
Simon Bomken, Aengus O'Marcaigh, Gladstone A A Burke, Leila Jahangiri, Liam C. Lee, Suzanne D. Turner, Olivier Giger, Helen J. Blair, Natalie Bell, Sorcha Forde, Tim Malcolm, Lukas Kenner, Owen P. Smith, Jamie D. Matthews, Nina Prokoph
Publikováno v:
British Journal of Haematology. 192:354-365
Burkitt lymphoma (BL) accounts for almost two-thirds of all B-cell non-Hodgkin lymphoma (B-NHL) in children and adolescents and is characterised by a MYC translocation and rapid cell turnover. Intensive chemotherapeutic regimens have been developed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2520562cee1ed90b793291585856d81d
https://doi.org/10.1111/bjh.17043
https://doi.org/10.1111/bjh.17043
Autor:
Petra Kodajova, Sonia Sánchez Martínez, Nicola A. Probst, Liam C. Lee, Ines Garces de los Fayos Alonso, Miaojun Han, Sandra Högler, Joaquín Pastor, G. A. Amos Burke, C. Patrick Reynolds, Hong Kai Lim, Eleanor Manners, Carmen Blanco-Aparicio, Leila Jahangiri, Jamie D. Matthews, Ji Luo, Suzanne D. Turner, Nina Prokoph, Simone Tangermann, Lukas Kenner, Olaf Merkel, Ricky M Trigg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nature Communications
Repisalud
Instituto de Salud Carlos III (ISCIII)
Resistance to anaplastic lymphoma kinase (ALK)-targeted therapy in ALK-positive non-small cell lung cancer has been reported, with the majority of acquired resistance mechanisms relying on bypass signaling. To proactively identify resistance mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced51d17bd4e3809b2cf33e72bf7a838
http://link.springer.com/article/10.1038/s41467-019-13315-x
http://link.springer.com/article/10.1038/s41467-019-13315-x
Autor:
Oliver Florey, Liam C. Lee, Lewis Timimi, Rupert Beale, Beatriz Montaner, Andrew Daley, J Kenneth Baillie, Elena Marcassa, Suzanne D. Turner, Rachel Ulferts
Although commonly associated with autophagosomes, LC3 can also be recruited to membranes in a variety of non-canonical contexts. These include responses to ionophores such as the M2 proton channel of influenza A virus. LC3 is attached to membranes by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::232e31b77e0aa609390f7f6027034386
https://doi.org/10.1101/2020.11.18.388306
https://doi.org/10.1101/2020.11.18.388306