Zobrazeno 1 - 10
of 1 890
pro vyhledávání: '"Liam C"'
Autor:
Liam C. O’Connell, Victoria Johnson, Jessica P. Otis, Anika K. Hutton, Anastasia C. Murthy, Mark C. Liang, Szu-Huan Wang, Nicolas L. Fawzi, Kimberly L. Mowry
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Proteins containing both intrinsically disordered regions (IDRs) and RNA binding domains (RBDs) can phase separate in vitro, forming bodies similar to cellular biomolecular condensates. However, how IDR and RBD domains contribute to in vivo
Externí odkaz:
https://doaj.org/article/ba55eec39d9e48a8bad7b8e990f85b70
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
We present a genome assembly from one female Acrobasis consociella (the Broad-barred Knot-horn; Arthropoda; Insecta; Lepidoptera; Pyralidae). The genome sequence is 598.4 megabases in span. Most of the assembly is scaffolded into 31 chromosomal pseud
Externí odkaz:
https://doaj.org/article/ba8a117802254976bd7f87e6ac3cbd00
Autor:
Ben Goldacre, David Evans, Sam Harper, Richard Croker, Christopher Wood, Brian MacKenna, Elizabeth Beech, Chris Bates, Amir Mehrkar, Peter Inglesby, Jonathan Cockburn, John Parry, Frank Hester, Kieran Hand, Helen Curtis, Rose Higgins, Andrew D Brown, Simon Davy, George Hickman, Tom Ward, Rebecca M Smith, Louis Fisher, Iain Dillingham, Steven Maude, Lucy Bridges, Linda Gough, Christine Cunningham, Victoria Speed, Ben FC Butler-Cole, Sebastian CJ Bacon, Thomas O'Dwyer, Liam C Hart
Publikováno v:
BMJ Medicine, Vol 3, Iss 1 (2024)
Objective To investigate the effect of the covid-19 pandemic on the number of patients with group A streptococcal infections and related antibiotic prescriptions.Design Retrospective cohort study in England using OpenSAFELY-TPP.Setting Primary care p
Externí odkaz:
https://doaj.org/article/76a3f50c7f87442e84bd0cb88b74f1ba
Autor:
Perla Pucci, Liam C. Lee, Miaojun Han, Jamie D. Matthews, Leila Jahangiri, Michaela Schlederer, Eleanor Manners, Annabel Sorby-Adams, Joshua Kaggie, Ricky M. Trigg, Christopher Steel, Lucy Hare, Emily R. James, Nina Prokoph, Stephen P. Ducray, Olaf Merkel, Firkret Rifatbegovic, Ji Luo, Sabine Taschner-Mandl, Lukas Kenner, G. A. Amos Burke, Suzanne D. Turner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Targeting Anaplastic lymphoma kinase (ALK) is a promising therapeutic strategy for aberrant ALK-expressing malignancies including neuroblastoma, but resistance to ALK tyrosine kinase inhibitors (ALK TKI) is a distinct possibility necessitati
Externí odkaz:
https://doaj.org/article/12cef060f54047bf95b2dad4e211f0d7
Autor:
Liam C. Hunt, Vishwajeeth Pagala, Anna Stephan, Boer Xie, Kiran Kodali, Kanisha Kavdia, Yong-Dong Wang, Abbas Shirinifard, Michelle Curley, Flavia A. Graca, Yingxue Fu, Suresh Poudel, Yuxin Li, Xusheng Wang, Haiyan Tan, Junmin Peng, Fabio Demontis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Ubiquitination is a post-translational modification initiated by the E1 enzyme UBA1, which transfers ubiquitin to ~35 E2 ubiquitin-conjugating enzymes. While UBA1 loss is cell lethal, it remains unknown how partial reduction in UBA1 activity
Externí odkaz:
https://doaj.org/article/ecc3809ff4864ac888167d9faaecd3c0
Autor:
Flavia A. Graca, Mamta Rai, Liam C. Hunt, Anna Stephan, Yong-Dong Wang, Brittney Gordon, Ruishan Wang, Giovanni Quarato, Beisi Xu, Yiping Fan, Myriam Labelle, Fabio Demontis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Myofiber atrophy occurs in many diseases but the mechanisms responsible for myofiber size determination are incompletely understood. Here, the authors show that the muscle-secreted factor Fibcd1 is necessary to maintain myofiber size and mitigates my
Externí odkaz:
https://doaj.org/article/5cbdb4d779ef41379fe96cd79ef579e7
Autor:
Liam C Butchart
Publikováno v:
Tzu-Chi Medical Journal, Vol 34, Iss 1, Pp 107-112 (2022)
The stress that the COVID-19 pandemic has placed on health systems internationally has forced difficult decisions concerning the rationing of medical care and has put the bioethical structures that inform those choices under scrutiny. Often, ethical
Externí odkaz:
https://doaj.org/article/22dbb8efda7948c5b83f5e1fdf4565c2
Publikováno v:
Evolutionary Applications, Vol 14, Iss 10, Pp 2516-2526 (2021)
Abstract Quantifying the extent to which animals detect and respond to human presence allows us to identify pressure (disturbance) and inform conservation management objectively; however, obtaining baselines against which to compare human impact is h
Externí odkaz:
https://doaj.org/article/855496e0bbbe44fea6d409204779fcb5
Autor:
Liam C. Hunt, Bronwen Schadeberg, Jared Stover, Benard Haugen, Vishwajeeth Pagala, Yong-Dong Wang, Jason Puglise, Elisabeth R. Barton, Junmin Peng, Fabio Demontis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Sarcopenia is the age-associated functional decline and atrophy of muscle fibers, and it has been proposed that it might be counteracted by inducing myofiber hypertrophy. Here, the authors show that expression levels of the ubiquitin ligase UBR4 are
Externí odkaz:
https://doaj.org/article/696daac57df34ee1ab4b69517f4a1f99
Publikováno v:
Frontiers in Marine Science, Vol 9 (2022)
Quantifying how animals use key habitats and resources for their survival allows managers to optimise conservation planning; however, obtaining representative sample sizes of wildlife distributions in both time and space is challenging, particularly
Externí odkaz:
https://doaj.org/article/d582140ffa8c47929308017dd98c7f41