Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Liam Bolt"'
Autor:
Rik G.H. Lindeboom, Kaylee B. Worlock, Lisa M. Dratva, Masahiro Yoshida, David Scobie, Helen R. Wagstaffe, Laura Richardson, Anna Wilbrey-Clark, Josephine L. Barnes, Krzysztof Polanski, Jessica Allen-Hyttinen, Puja Mehta, Dinithi Sumanaweera, Jacqueline Boccacino, Waradon Sungnak, Ni Huang, Lira Mamanova, Rakesh Kapuge, Liam Bolt, Elena Prigmore, Ben Killingley, Mariya Kalinova, Maria Mayer, Alison Boyers, Alex Mann, Vitor Teixeira, Sam M. Janes, Rachel C. Chambers, Muzlifah Haniffa, Andrew Catchpole, Robert Heyderman, Mahdad Noursadeghi, Benny Chain, Andreas Mayer, Kerstin B. Meyer, Christopher Chiu, Marko Z. Nikolić, Sarah A. Teichmann
The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the cellular disease dynamics remains limited. In our unique COVID-19 human challenge study we used single cell genomics of nasopharyngeal swabs and blood to temporall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d220950228bcc70a9b7e6d3734f32b9f
https://doi.org/10.1101/2023.04.13.23288227
https://doi.org/10.1101/2023.04.13.23288227
Autor:
Kazumasa Kanemaru, James Cranley, Daniele Muraro, Antonio M.A. Miranda, Jan Patrick Pett, Monika Litvinukova, Natsuhiko Kumasaka, Siew Yen Ho, Krzysztof Polanski, Laura Richardson, Lukas Mach, Monika Dabrowska, Nathan Richoz, Sam N. Barnett, Shani Perera, Anna Wilbrey-Clark, Carlos Talavera-López, Ilaria Mulas, Krishnaa T. Mahbubani, Liam Bolt, Lira Mamanova, Liz Tuck, Lu Wang, Margaret M. Huang, Martin Prete, Sophie Pritchard, John Dark, Kourosh Saeb-Parsy, Minal Patel, Menna R. Clatworthy, Norbert Hübner, Rasheda A. Chowdhury, Michela Noseda, Sarah A. Teichmann
A cell’s function is defined by its intrinsic characteristics and its niche: the tissue microenvironment in which it dwells. Here, we combine single-cell and spatial transcriptomic data to discover cellular niches within eight regions of the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f76444d5783c68c780deca00434aee0
https://doi.org/10.1101/2023.01.30.526202
https://doi.org/10.1101/2023.01.30.526202
Autor:
Ruoyan Li, John R. Ferdinand, Kevin W. Loudon, Georgina S. Bowyer, Sean Laidlaw, Francesc Muyas, Lira Mamanova, Joana B. Neves, Liam Bolt, Eirini S. Fasouli, Andrew R.J. Lawson, Matthew D. Young, Yvette Hooks, Thomas R.W. Oliver, Timothy M. Butler, James N. Armitage, Tev Aho, Antony C.P. Riddick, Vincent Gnanapragasam, Sarah J. Welsh, Kerstin B. Meyer, Anne Y. Warren, Maxine G.B. Tran, Grant D. Stewart, Isidro Cortés-Ciriano, Sam Behjati, Menna R. Clatworthy, Peter J. Campbell, Sarah A. Teichmann, Thomas J. Mitchell
Tumor behavior is intricately dependent on the oncogenic properties of cancer cells and their multi-cellular interactions. To understand these dependencies within the wider microenvironment, we studied over 270,000 single-cell transcriptomes and 100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158b71c82fe7745e4ec25d34b1051334
Autor:
Maximillian Woodall, Ana-Maria Cujba, Kaylee B. Worlock, Katie-Marie Case, Tereza Masonou, Masahiro Yoshida, Krzysztof Polanski, Ni Huang, Rik G. H. Lindeboom, Lira Mamanova, Liam Bolt, Laura Richardson, Samuel Ellis, Machaela Palor, Thomas Burgoyne, Andreia Pinto, Dale Moulding, Timothy D. McHugh, Aarash Saleh, Eliz Kilich, Puja Mehta, Chris O’Callaghan, Jie Zhou, Wendy Barclay, Paolo De Coppi, Colin R. Butler, Heloise Vinette, Sunando Roy, Judith Breuer, Rachel C. Chambers, Wendy E. Heywood, Kevin Mills, Robert E. Hynds, Sarah A. Teichmann, Kerstin B. Meyer, Marko Z. Nikolić, Claire M. Smith
Children infected with SARS-CoV-2 rarely progress to respiratory failure, but the risk of mortality in infected people over 85 years of age remains high, despite vaccination and improving treatment options. Here, we take a comprehensive, multidiscipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d879062a84c842d555af5dd10e4eba88
https://doi.org/10.1101/2023.01.16.524211
https://doi.org/10.1101/2023.01.16.524211
Autor:
Veronika R. Kedlian, Yaning Wang, Tianliang Liu, Xiaoping Chen, Liam Bolt, Zhuojian Shen, Eirini S. Fasouli, Elena Prigmore, Vitalii Kleshchevnikov, Tong Li, John E Lawrence, Ni Huang, Qin Guo, Lu Yang, Krzysztof Polański, Monika Dabrowska, Catherine Tudor, Xiaobo Li, Omer Bayraktar, Minal Patel, Kerstin B. Meyer, Natsuhiko Kumasaka, Krishnaa T. Mahbubani, Andy Peng Xiang, Kourosh Saeb-Parsy, Sarah A Teichmann, Hongbo Zhang
Skeletal muscle ageing increases the incidence of age-associated frailty and sarcopenia in the elderly worldwide, leading to increased morbidity and mortality. However, our understanding of the cellular and molecular mechanisms of muscle ageing is st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e30ff6d44870bf32b0d34ea3caa423fe
https://doi.org/10.1101/2022.05.24.493094
https://doi.org/10.1101/2022.05.24.493094
Autor:
Kerstin Meyer, Elo Madissoon, Amanda Oliver, Vitalii Kleshchevnikov, Anna Wilbrey-Clark, Krzysztof Polański, Nathan Richoz, Ana Elisa Ribeiro Orsi, Lira Mamanova, Liam Bolt, Rasa Elmentaite, Jan Pett, Ni Huang, Chuan Xu, Peng He, Monika Dabrowska, Sophie Pritchard, Elizabeth Tuck, Elena Prigmore, Shani Perera, Andrew Knights, Agnes Oszlanczi, Adam Hunter, Sara Filipa Vieira, Minal Patel, Masahiro Yoshida, Kaylee Worlock, Rik Lindeboom, Marko Nikolic, Nikitas Georgakopoulos, Krishna Mahbubani, Kourosh Saeb-Parsy, Omer Ali Bayraktar, Menna Clatworthy, Oliver Stegle, Natsuhiko Kumasaka, Sarah Teichmann
To (re)define tissue architecture of the lung and airways at the cellular and molecular level, we profiled five proximal-to-distal locations of healthy human lungs in depth using multi-omic single cell/nuclei and Visium Spatial Transcriptomics. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adc360382d632f87b2aa4fbae3cabbbc
https://doi.org/10.21203/rs.3.rs-1650134/v1
https://doi.org/10.21203/rs.3.rs-1650134/v1
Autor:
Bao Zhang, Peng He, John E Lawrence, Shuaiyu Wang, Elizabeth Tuck, Brian A Williams, Kenny Roberts, Vitalii Kleshchevnikov, Lira Mamanova, Liam Bolt, Krzysztof Polanski, Rasa Elmentaite, Eirini S Fasouli, Martin Prete, Xiaoling He, Nadav Yayon, Yixi Fu, Hao Yang, Chen Liang, Hui Zhang, Raphael Blain, Alain Chedotal, David R. FitzPatrick, Helen Firth, Andrew Dean, John C Marioni, Roger A Barker, Mekayla A Storer, Barbara J Wold, Hongbo Zhang, Sarah A Teichmann
Human limbs emerge during the fourth post-conception week as mesenchymal buds which develop into fully-formed limbs over the subsequent months. Limb development is orchestrated by numerous temporally and spatially restricted gene expression programme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89383041d1b982d74699809d6916ebe9
https://doi.org/10.1101/2022.04.27.489800
https://doi.org/10.1101/2022.04.27.489800
Autor:
Amanda Oliver, Elo Madissoon, Vitalii Kleshchevnikov, Anna Wilbrey-Clark, Kryzysztof Polanski, Ana Elisa Ribeiro Orsi, Lira Mamanova, Liam Bolt, J. Patrick Pett, Ni Huang, Rasa Elmentaite, Nathan Richoz, Peng He, Monika Dabrowska, Liz Tuck, Elena Prigmore, Andrew Knights, Agnes Oszlanczi, Adam Hunter, Sophie Pritchard, Sara Filipa Vieira, Minal Patel, Krishnaa Mahbubani, Nikitas Georgakapopoulos, Menna Clatworthy, Oliver Stegle, Kourosh Saeb-Parsy, Natsuhiko Kumasaka, Sarah Teichmann, Kerstin Meyer
Publikováno v:
Airway cell biology and immunopathology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39b699f45c890802add6218f07665583
https://doi.org/10.1183/23120541.lsc-2022.152
https://doi.org/10.1183/23120541.lsc-2022.152
Mapping Single Cell Transcriptomes in the Intra-Tumoural and Associated Territories of Kidney Cancer
Autor:
Ruoyan Li, John R. Ferdinand, Kevin Loudon, Georgina S. Bowyer, Sean Laidlaw, Lira Mamanova, Joana B. Neves, Liam Bolt, Eirini Fasouli, Andrew Lawson, Matthew Young, Yvette Hooks, Thomas Oliver, Timothy M. Butler, James Armitage, Tev Aho, Anthony C. P. Riddick, Vincent Gnanapragasam, Sarah Welsh, Kerstin Meyer, Anne Warren, Maxine G. B. Tran, Grant Stewart, Sam Behjati, Menna R. Clatworthy, Peter J. Campbell, Sarah Teichmann, Thomas Mitchell
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::887982cd5a73353c0f36552caadfd289
https://doi.org/10.2139/ssrn.4132721
https://doi.org/10.2139/ssrn.4132721
Autor:
Peng He, Kyungtae Lim, Dawei Sun, Jan Patrick Pett, Quitz Jeng, Krzysztof Polanski, Ziqi Dong, Liam Bolt, Laura Richardson, Lira Mamanova, Monika Dabrowska, Anna Wilbrey-Clark, Elo Madissoon, Zewen Kelvin Tuong, Emma Dann, Chenqu Suo, Isaac Goh, Masahiro Yoshida, Marko Z Nikolić, Sam M Janes, Xiaoling He, Roger A Barker, Sarah A Teichmann, John C. Marioni, Kerstin B Meyer, Emma L Rawlins
Publikováno v:
Cell. 185:4841-4860.e25
We present a multiomic cell atlas of human lung development that combines single cell RNA and ATAC sequencing, high throughput spatial transcriptomics and single cell imaging. Coupling single cell methods with spatial analysis has allowed a comprehen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2004b9795fc41ebe14d787333c315da4
https://doi.org/10.1016/j.cell.2022.11.005
https://doi.org/10.1016/j.cell.2022.11.005