Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Liam Baird"'
Autor:
Miu Sato, Nahoko Yaguchi, Takuya Iijima, Aki Muramatsu, Liam Baird, Takafumi Suzuki, Masayuki Yamamoto
Publikováno v:
Redox Biology, Vol 77, Iss , Pp 103355- (2024)
In the KEAP1-NRF2 stress response system, KEAP1 acts as a sensor for oxidative and electrophilic stresses through formation of S–S bond and C–S bond, respectively. Of the many questions left related to the sensor activity, following three appear
Externí odkaz:
https://doaj.org/article/9153399d75a44ac98cb523fb1b48eb9c
Autor:
Liam Baird, Masayuki Yamamoto
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102904- (2023)
In human cancer, activating mutations in the KEAP1-NRF2 pathway are frequently observed, and positively selected for, as they confer the cytoprotective functions of the transcription factor NRF2 on the cancer cells. This results in the development of
Externí odkaz:
https://doaj.org/article/5c673e17ae694d8bafc40b0127a182f3
A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells
Autor:
Liam Baird, Keiko Taguchi, Anqi Zhang, Yushi Takahashi, Takafumi Suzuki, Thomas W. Kensler, Masayuki Yamamoto
Publikováno v:
Redox Biology, Vol 66, Iss , Pp 102845- (2023)
While it is well established that the KEAP1-NRF2 pathway regulates the main inducible cellular response to oxidative stress, this cytoprotective function of NRF2 could become deleterious to the host if it confers survival onto irreparably damaged cel
Externí odkaz:
https://doaj.org/article/05330e90b7e04718bade953250368fe1
Autor:
Takafumi Suzuki, Shiori Seki, Keiichiro Hiramoto, Eriko Naganuma, Eri H. Kobayashi, Ayaka Yamaoka, Liam Baird, Nobuyuki Takahashi, Hiroshi Sato, Masayuki Yamamoto
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nrf2 regulates oxidative and electrophilic stress responses by modulating the expression of enzymes involved in detoxification pathways. Here Suzukiet al. show that Nrf2 activation in early tubular development promotes nephrogenic diabetes insipidus
Externí odkaz:
https://doaj.org/article/3b00ffd91f464610914a1c75a688d5dc
Autor:
Takafumi Suzuki, Aki Muramatsu, Ryota Saito, Tatsuro Iso, Takahiro Shibata, Keiko Kuwata, Shin-ichi Kawaguchi, Takao Iwawaki, Saki Adachi, Hiromi Suda, Masanobu Morita, Koji Uchida, Liam Baird, Masayuki Yamamoto
Publikováno v:
Cell Reports, Vol 28, Iss 3, Pp 746-758.e4 (2019)
Summary: The Keap1-Nrf2 system plays a central role in the oxidative stress response; however, the identity of the reactive oxygen species sensor within Keap1 remains poorly understood. Here, we show that a Keap1 mutant lacking 11 cysteine residues r
Externí odkaz:
https://doaj.org/article/8f429184c0984c30b6ecf2c024ee31bf
Autor:
Kira M. Holmström, Liam Baird, Ying Zhang, Iain Hargreaves, Annapurna Chalasani, John M. Land, Lee Stanyer, Masayuki Yamamoto, Albena T. Dinkova-Kostova, Andrey Y. Abramov
Publikováno v:
Biology Open, Vol 2, Iss 8, Pp 761-770 (2013)
Summary Transcription factor Nrf2 and its repressor Keap1 regulate a network of cytoprotective genes involving more than 1% of the genome, their best known targets being drug-metabolizing and antioxidant genes. Here we demonstrate a novel role for th
Externí odkaz:
https://doaj.org/article/26dac259a99f41a389e0e6b0bb732556
Autor:
Masayuki Yamamoto, Tatsuhiro Shibata, Masahito Ebina, Keiko Igarashi, Hirofumi Rokutan, Lei Yu, Liam Baird, Daisuke Saigusa, Takashi Moriguchi, Hironori Satoh
Supplementary Materials and Methods and Supplementary Figure Legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c36919056a3dc7ae0334d4737cc3070
https://doi.org/10.1158/0008-5472.22407912.v1
https://doi.org/10.1158/0008-5472.22407912.v1
Autor:
Masayuki Yamamoto, Tatsuhiro Shibata, Masahito Ebina, Keiko Igarashi, Hirofumi Rokutan, Lei Yu, Liam Baird, Daisuke Saigusa, Takashi Moriguchi, Hironori Satoh
Nrf2 activation promotes resistance to chemical carcinogenesis in animal models, but activating mutations in Nrf2 also confer malignant characters to human cells by activating antioxidative/detoxifying enzymes and metabolic reprogramming. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c81c8bed80d8d3719cae0e3560b16213
https://doi.org/10.1158/0008-5472.c.6507411.v1
https://doi.org/10.1158/0008-5472.c.6507411.v1
Autor:
Masayuki Yamamoto, Tatsuhiro Shibata, Masahito Ebina, Keiko Igarashi, Hirofumi Rokutan, Lei Yu, Liam Baird, Daisuke Saigusa, Takashi Moriguchi, Hironori Satoh
RT-qPCR analysis of urethane detoxification enzymes in the liver of the Keap1-wt mice and Keap1-kd mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e91e817a7dd833ed1caf1bdfd01feb
https://doi.org/10.1158/0008-5472.22407921.v1
https://doi.org/10.1158/0008-5472.22407921.v1
Autor:
Masayuki Yamamoto, Tatsuhiro Shibata, Masahito Ebina, Keiko Igarashi, Hirofumi Rokutan, Lei Yu, Liam Baird, Daisuke Saigusa, Takashi Moriguchi, Hironori Satoh
Nrf2-target genes showing differential expression patterns between the Keap1-wt and the Keap1-kd tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08eb3974828437f0a2a5599f19697525
https://doi.org/10.1158/0008-5472.22407915
https://doi.org/10.1158/0008-5472.22407915