Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Liam B King"'
Autor:
Kelly C L Shaffer, Sean Hui, Anna Bratcher, Liam B King, Rachel Mutombe, Nathalie Kavira, Jean Paul Kompany, Merly Tambu, Kamy Musene, Patrick Mukadi, Placide Mbala, Adva Gadoth, Brandyn R West, Benoit Kebela Ilunga, Didine Kaba, Jean Jacques Muyembe-Tanfum, Nicole A Hoff, Anne W Rimoin, Erica Ollmann Saphire
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 3, p e0010167 (2022)
Although multiple antigenically distinct ebolavirus species can cause human disease, previous serosurveys focused on only Zaire ebolavirus (EBOV). Thus, the extent of reactivity or exposure to other ebolaviruses, and which sociodemographic factors ar
Externí odkaz:
https://doaj.org/article/e6920166dc554d05ac47096d21e79aa1
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e44211 (2012)
Lassa virus causes hemorrhagic fever characterized by immunosuppression. The nucleoprotein of Lassa virus, termed NP, binds the viral genome. It also has an additional enzymatic activity as an exonuclease that specifically digests double-stranded RNA
Externí odkaz:
https://doaj.org/article/cd2032847db848a7bc03a3115e730eea
Autor:
Liam B. King, Brandyn R. West, Crystal L. Moyer, Pavlo Gilchuk, Andrew Flyak, Philipp A. Ilinykh, Robin Bombardi, Sean Hui, Kai Huang, Alexander Bukreyev, James E. Crowe, Erica Ollmann Saphire
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Human antibodies cross-reactive for several viruses within the Ebolavirus genus have been identified. Here the authors present the crystal structure of such a neutralizing monoclonal antibody (mAb) targeting the stalk of Bundibugyo virus glycoprotein
Externí odkaz:
https://doaj.org/article/9c896c7320b3408db2980180804deb30
Autor:
Brandyn R. West, Crystal L. Moyer, Liam B. King, Marnie L. Fusco, Jacob C. Milligan, Sean Hui, Erica Ollmann Saphire
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Only one naturally occurring human antibody has been described thus far that is capable of potently neutralizing all five ebolaviruses. Here we present two crystal structures of this rare, pan-ebolavirus neutralizing human antibody in comple
Externí odkaz:
https://doaj.org/article/5ac7f3a7134e439788c3a2f6d1f411d9
Autor:
Kelly C. L. Shaffer, Sean Hui, Anna Bratcher, Liam B. King, Rachel Mutombe, Nathalie Kavira, Jean Paul Kompany, Merly Tambu, Kamy Musene, Patrick Mukadi, Placide Mbala, Adva Gadoth, Brandyn R. West, Benoit Kebela Ilunga, Didine Kaba, Jean Jacques Muyembe-Tanfum, Nicole A. Hoff, Anne W. Rimoin, Erica Ollmann Saphire
Publikováno v:
PLoS neglected tropical diseases, vol 16, iss 3
Although multiple antigenically distinct ebolavirus species can cause human disease, previous serosurveys focused on only Zaire ebolavirus (EBOV). Thus, the extent of reactivity or exposure to other ebolaviruses, and which sociodemographic factors ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e674e48a68e2b951a5f76649f8be9e8
https://escholarship.org/uc/item/8tz3225s
https://escholarship.org/uc/item/8tz3225s
Autor:
Marcus Vg Lacerda, Fernando Val, Jose Diego Brito-Sousa, André Siqueira, Fabio T. M. Costa, Quique Bassat, Wuelton Marcelo Monteiro, Liam B. King, Lucio Luzzatto
Publikováno v:
Future Microbiology. 14:1261-1279
Malaria puts more than 3 billion people at risk of infection and causes high morbidity and mortality. Plasmodium vivax forms hypnozoites, which may initiate recurrences, even in the absence of reinfection or superinfection. Until recently, the only d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3021447d49320a4d624256a99835e39c
https://doi.org/10.2217/fmb-2019-0202
https://doi.org/10.2217/fmb-2019-0202
Publikováno v:
Current Opinion in Virology. 34:140-148
Filoviruses are the causative agents of highly lethal outbreaks in sub-Saharan Africa. Although an experimental vaccine and several therapeutics are being deployed in the Democratic Republic of Congo to combat the ongoing Ebola virus outbreak, these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b97df0e751bb4b9f15a87438534eeaf
https://doi.org/10.1016/j.coviro.2019.01.003
https://doi.org/10.1016/j.coviro.2019.01.003
Autor:
Robin G. Bombardi, Erica Ollmann Saphire, Alexander Bukreyev, Andrew I. Flyak, Crystal L. Moyer, Pavlo Gilchuk, Liam B. King, Sean Hui, Brandyn R. West, Kai Huang, Philipp A. Ilinykh, James E. Crowe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Nature Communications
Nature Communications
Three Ebolavirus genus viruses cause lethal disease and lack targeted therapeutics: Ebola virus, Sudan virus and Bundibugyo virus. Monoclonal antibody (mAb) cocktails against the surface glycoprotein (GP) present a potential therapeutic strategy. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f71683ae16f9d3ecca14f00785b7f1
https://doi.org/10.1038/s41467-019-09732-7
https://doi.org/10.1038/s41467-019-09732-7
Autor:
Sean Hui, Marnie L. Fusco, Jacob C. Milligan, Liam B. King, Erica Ollmann Saphire, Crystal L. Moyer, Brandyn R. West
Publikováno v:
mBio
mBio, Vol 9, Iss 5 (2018)
mBio, Vol 9, Iss 5, p e01674-18 (2018)
mBio, Vol 9, Iss 5 (2018)
mBio, Vol 9, Iss 5, p e01674-18 (2018)
The Ebolavirus genus has at least five members, four of which are known to cause deadly disease in humans. An ideal therapy or a vaccine would protect against all ebolaviruses, but identifying a common weakness in all of them has remained elusive.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5735a4359946857aad449149be49bf
https://pubmed.ncbi.nlm.nih.gov/30459187
https://pubmed.ncbi.nlm.nih.gov/30459187
Autor:
Bronwyn M. Gunn, Marnie L. Fusco, Robert N. Kirchdoerfer, Erica Ollmann Saphire, Kai Huang, Amandeep K. Sangha, Jens Meiler, Alexander Bukreyev, Andrew I. Flyak, Kathryn M. Hastie, Galit Alter, Liam B. King, Philipp A. Ilinykh, James E. Crowe
Since their first identification 50 years ago, marburgviruses have emerged several times, with 83%–90% lethality in the largest outbreaks. Although no vaccines or therapeutics are available for human use, the human antibody MR191 provides complete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738748099781eb04f5ede51d99079023
https://europepmc.org/articles/PMC5772738/
https://europepmc.org/articles/PMC5772738/