Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Liam A Hurst"'
Autor:
Eleanor eRaffan, Liam A Hurst, Saeed eAl Turki, Gillian eCarpenter, Carol eScott, Allan eDaly, Alison eCoffey, Sanjeev eBhaskar, Eleanor eHoward, Naz eKhan, Helen eKingston, Aarno ePalotie, David Bousfield Savage, Mark eO'Driscoll, Claire eSmith, Stephen eO'Rahilly, Inês eBarroso, Robert Kenneth Semple
Publikováno v:
Frontiers in Endocrinology, Vol 2 (2011)
Genetic diagnosis of inherited metabolic disease is conventionally achieved through syndrome recognition and targeted gene sequencing, but many patients receive no specific diagnosis. Next generation sequencing allied to capture of expressed sequence
Externí odkaz:
https://doaj.org/article/061229dc1d424498986ed6fa52ec7949
Autor:
Liam A. Hurst, Benjamin J. Dunmore, Lu Long, Alexi Crosby, Rafia Al-Lamki, John Deighton, Mark Southwood, Xudong Yang, Marko Z. Nikolic, Blanca Herrera, Gareth J. Inman, John R. Bradley, Amer A. Rana, Paul D. Upton, Nicholas W. Morrell
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Reduced BMP receptor II signalling underlies pulmonary arterial hypertension (PAH). Here, Hurstet al. show that TNFα subverts BMP signalling by increasing BMP6 expression and signalling via an alternative BMP receptor, ALK2, in pulmonary artery smoo
Externí odkaz:
https://doaj.org/article/17874564742043b0848f710d036fb95a
Autor:
Fedir Kiskin, Liam A. Hurst, Hui Zhang, Sandra Schoors, Carol Perez-Iratxeta, Peter Carmeliet, Nicholas W. Morrell, Charaka Hadinnapola, Paul D. Upton, Jessie R. Lavoie, Mark L. Ormiston, Mohamad Taha, Angelo D'Alessandro, Paola Caruso, Claudia Dos Santos, Duncan J. Stewart, Kenny Schlosser, Maria G. Frid, Benjamin J. Dunmore, Akiko Hata, Kurt R. Stenmark, Amanda Flockton, Lu Long
Publikováno v:
Circulation. 136(25)
Background: Pulmonary arterial hypertension (PAH) is characterized by abnormal growth and enhanced glycolysis of pulmonary artery endothelial cells. However, the mechanisms underlying alterations in energy production have not been identified. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bee3feff86f344d7a86c52b4589386
https://pubmed.ncbi.nlm.nih.gov/29255124
https://pubmed.ncbi.nlm.nih.gov/29255124
Autor:
Liam A, Hurst, Benjamin J, Dunmore, Lu, Long, Alexi, Crosby, Rafia, Al-Lamki, John, Deighton, Mark, Southwood, Xudong, Yang, Marko Z, Nikolic, Blanca, Herrera, Gareth J, Inman, John R, Bradley, Amer A, Rana, Paul D, Upton, Nicholas W, Morrell
Publikováno v:
Nature Communications
Heterozygous germ-line mutations in the bone morphogenetic protein type-II receptor (BMPR-II) gene underlie heritable pulmonary arterial hypertension (HPAH). Although inflammation promotes PAH, the mechanisms by which inflammation and BMPR-II dysfunc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d341c80105201d1ee4519c34b940394e
https://pubmed.ncbi.nlm.nih.gov/28084316
https://pubmed.ncbi.nlm.nih.gov/28084316
Autor:
Daniel I. Nathan, Daniel Bloch, Olle Melander, Dongjian Hu, Pankaj Arora, Stefan Janssens, Kenneth D. Bloch, Thomas J. Wang, Connie Wu, Kaitlin Allen, Pawina Jiramongkolchai, Liam A. Hurst, Emmanuel S. Buys, Obiajulu Agha, Christopher Newton-Cheh, Ibrahim J. Domian, J. Gustav Smith, Sander Trenson
Publikováno v:
Molecular and Cellular Biology
Atrial natriuretic peptide (ANP) has a central role in regulating blood pressure in humans. Recently, microRNA 425 (miR-425) was found to regulate ANP production by binding to the mRNA of NPPA, the gene encoding ANP. mRNAs typically contain multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a640b6d3bfdc0ae8e875e7394a7466
https://pubmed.ncbi.nlm.nih.gov/27185878
https://pubmed.ncbi.nlm.nih.gov/27185878
Autor:
Lauren Baker, Nick E.J. West, Nichola Figg, Antonio Vidal-Puig, Daniel R. Obaid, Sheetal Kumar, John Mercer, Martin R. Bennett, Emma Yu, James Harrison, Murray C.H. Clarke, Patrick A. Calvert, Michael P. Murphy, Angela Logan, Julie C. Wang, Liam A. Hurst
Background— Mitochondrial DNA (mtDNA) damage occurs in both circulating cells and the vessel wall in human atherosclerosis. However, it is unclear whether mtDNA damage directly promotes atherogenesis or is a consequence of tissue damage, which cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17575dff177f38fca631e422d818bc32
Autor:
Paola Caruso, C Dos Santos, Duncan J. Stewart, Kenny Schlosser, Mark L. Ormiston, Benjamin J. Dunmore, Jessie R. Lavoie, Peter Carmeliet, Lu Long, Nicholas W. Morrell, Carol Perez-Iratxeta, Akiko Hata, Liam A. Hurst, Sandra Schoors
Publikováno v:
Thorax. 71:A48.2-A49
Introduction Pulmonary arterial hypertension (PAH) is a rare desease characterised by profound vascular abnormalities in the peripheral arteries of the lung, leading to a progressive increase in pulmonary vascular resistance, right heart failure and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57ac139fe95ab3dee9172086f9658524
https://doi.org/10.1136/thoraxjnl-2016-209333.90
https://doi.org/10.1136/thoraxjnl-2016-209333.90
Autor:
Lauren Baker, Liam A. Hurst, Julie C. Wang, Michael P. Murphy, John Mercer, James Harrison, Sheetal Kumar, N. Figg, Daniel R. Obaid, Martin R. Bennett, Antonio Vidal-Puig, Angela Logan, Murray C.H. Clarke, Nick E.J. West, Emma Yu, Patrick A. Calvert
Publikováno v:
Atherosclerosis. 232:e3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c665700cc49c0dba55e5ce6d6f14cbcd
https://doi.org/10.1016/j.atherosclerosis.2013.11.005
https://doi.org/10.1016/j.atherosclerosis.2013.11.005
Publikováno v:
Thorax. 68:A1.1-A1
Background Mutations in BMP type II receptor (BMPR-II) account for 70% of heritable pulmonary arterial hypertension (PAH) cases, but low penetrance (~20%) in mutation carriers implies a ‘second hit’ is required for disease initiation. Inflammatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d91b69ba1d7286de8dc3ea6c6176ea39
https://doi.org/10.1136/thoraxjnl-2013-204457.1
https://doi.org/10.1136/thoraxjnl-2013-204457.1
Publikováno v:
Thorax. 67:A22.1-A22
Mutations in the bone morphogenetic protein type-II receptor (BMPR-II) underlie ∼70% of heritable pulmonary arterial hypertension (PAH) cases. However, the low penetrance in mutation carriers implies a ‘second hit’ is required for disease onset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d7614a3accc72c70c8b4faf6d05d6fb
https://doi.org/10.1136/thoraxjnl-2012-202678.046
https://doi.org/10.1136/thoraxjnl-2012-202678.046