Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Liam, Portt"'
Autor:
Liam Portt, Melody A. Cobleigh, Sanja Turturro, Matthew S. Najor, Satnam Brar, Abde M. Abukhdeir, Timothy Yung
Publikováno v:
Cancer Research. 81:PS18-30
Background: The Ras signaling pathway is a key oncogenic growth signaling pathway. The neurofibromatosis gene (NF1) is a tumor suppressor gene and negative regulator of Ras. Approximately 20% of breast cancers experience loss of active NF1 protein, l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16fe5a357eaae6aec9f69ad5087a6a17
https://doi.org/10.1158/1538-7445.sabcs20-ps18-30
https://doi.org/10.1158/1538-7445.sabcs20-ps18-30
Autor:
Liam Portt, Melody A. Cobleigh, Timothy Yung, Matthew S. Najor, Abde M. Abukhdeir, Sanja Turturro, Christopher S. Malarkey
Publikováno v:
Breast Cancer Research and Treatment. 177:325-333
The PI3K pathway, which includes the PI3K catalytic subunits p110α (PIK3CA) and the PI3K regulatory subunit p85α (PIK3R1), is the most frequently altered pathway in cancer. We encountered a breast cancer patient whose tumor contained a somatic alte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b2815fcd20ba30ab9171fe0b0380472
https://doi.org/10.1007/s10549-019-05320-x
https://doi.org/10.1007/s10549-019-05320-x
Autor:
Sanja B, Turturro, Matthew S, Najor, Timothy, Yung, Liam, Portt, Christopher S, Malarkey, Abde M, Abukhdeir, Melody A, Cobleigh
Publikováno v:
Breast cancer research and treatment. 177(2)
The PI3K pathway, which includes the PI3K catalytic subunits p110α (PIK3CA) and the PI3K regulatory subunit p85α (PIK3R1), is the most frequently altered pathway in cancer. We encountered a breast cancer patient whose tumor contained a somatic alte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::93b97457d6a0cccf860c6202250dbc8a
https://pubmed.ncbi.nlm.nih.gov/31209687
https://pubmed.ncbi.nlm.nih.gov/31209687
Autor:
Satnam Brar, Sanja Turturro, Liam Portt, Matthew S. Najor, Timothy Yung, Abde M. Abukhdeir, Melody A. Cobleigh
Publikováno v:
Journal of Clinical Oncology. 36:e24284-e24284
e24284Background: The neurofibromatosis gene (NF1) is a negative regulator of the Ras protein and is lost in ~20% of breast cancers, leading to constitutive activation of Ras. Few studies have expl...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24cc5dc6e4b34a14fb52f6d1a3f7e0da
https://doi.org/10.1200/jco.2018.36.15_suppl.e24284
https://doi.org/10.1200/jco.2018.36.15_suppl.e24284
Autor:
Craig A. Mandato, P Ebner, Frank Madeo, Chamel Khoury, Hojatollah Vali, Sara Sheibani, Rawan Eid, Michael T. Greenwood, Grant Norman, Liam Portt, Caitlin Clapp
Publikováno v:
Cell Death & Disease
Expression of human Bax, a cardinal regulator of mitochondrial membrane permeabilization, causes death in yeast. We screened a human cDNA library for suppressors of Bax-mediated yeast death and identified human 14-3-3β/α, a protein whose paralogs h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d48fe98ff568e54b3c15d20ec8c0af
https://pubmed.ncbi.nlm.nih.gov/22785534
https://pubmed.ncbi.nlm.nih.gov/22785534
Autor:
Liam Portt, Sara Sheibani, Matthew Greenwood, Caitlin Clapp, Craig A. Mandato, Chamel Khoury, Rawan Eid, Michael T. Greenwood, Hojatollah Vali
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 2 (2012)
Frontiers in Oncology, Vol 2 (2012)
Genetically programmed cell death (PCD) mechanisms, including apoptosis, are important for the survival of metazoans since it allows, among things, the removal of damaged cells that interfere with normal function. Cell death due to PCD is observed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac13e21737679498c140a14532f80fa
https://pubmed.ncbi.nlm.nih.gov/22708116
https://pubmed.ncbi.nlm.nih.gov/22708116
Autor:
Drew Williams, Craig A. Mandato, Grant Norman, Liam Portt, Chamel Khoury, Aimee Laporte, Jennie G. Briard, Michael T. Greenwood, Naomi Metcalfe, Sara Sheibani
Publikováno v:
Biochimica et biophysica acta. 1813(2)
The identification of novel anti-apoptotic sequences has lead to new insights into the mechanisms involved in regulating different forms of programmed cell death. For example, the anti-apoptotic function of free radical scavenging proteins supports t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedf27c8e350f8b18a565769acb0675c
https://pubmed.ncbi.nlm.nih.gov/21145358
https://pubmed.ncbi.nlm.nih.gov/21145358
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (1):238-259
Type I programmed cell death (PCD) or apoptosis is critical for cellular self-destruction for a variety of processes such as development or the prevention of oncogenic transformation. Alternative forms, including type II (autophagy) and type III (nec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b458da53a6bdf18342a815280b831e6f