Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure

Autor: Danielle Rasooly, Gina M. Peloso, Alexandre C. Pereira, Hesam Dashti, Claudia Giambartolomei, Eleanor Wheeler, Nay Aung, Brian R. Ferolito, Maik Pietzner, Eric H. Farber-Eger, Quinn Stanton Wells, Nicole M. Kosik, Liam Gaziano, Daniel C. Posner, A. Patrícia Bento, Qin Hui, Chang Liu, Krishna Aragam, Zeyuan Wang, Brian Charest, Jennifer E. Huffman, Peter W. F. Wilson, Lawrence S. Phillips, John Whittaker, Patricia B. Munroe, Steffen E. Petersen, Kelly Cho, Andrew R. Leach, María Paula Magariños, John Michael Gaziano, VA Million Veteran Program, Claudia Langenberg, Yan V. Sun, Jacob Joseph, Juan P. Casas

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract We conduct a large-scale meta-analysis of heart failure genome-wide association studies (GWAS) consisting of over 90,000 heart failure cases and more than 1 million control individuals of European ancestry to uncover novel genetic determinan

Externí odkaz: https://doaj.org/article/121bbc31eec24459b300c8546850ced3

Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses

Autor: Liam Gaziano, Luanluan Sun, Matthew Arnold, Steven Bell, Kelly Cho, Stephen K. Kaptoge, Rebecca J. Song, Stephen Burgess, Daniel C. Posner, Katja Mosconi, Cassianne Robinson-Cohen, Amy M. Mason, Thomas R. Bolton, Ran Tao, Elias Allara, Petra Schubert, Lingyan Chen, James R. Staley, Natalie Staplin, Servet Altay, Pilar Amiano, Volker Arndt, Johan Ärnlöv, Elizabeth L.M. Barr, Cecilia Björkelund, Jolanda M.A. Boer, Hermann Brenner, Edoardo Casiglia, Paolo Chiodini, Jackie A. Cooper, Josef Coresh, Mary Cushman, Rachel Dankner, Karina W. Davidson, Renate T. de Jongh, Chiara Donfrancesco, Gunnar Engström, Heinz Freisling, Agustín Gómez de la Cámara, Vilmundur Gudnason, Graeme J. Hankey, Per-Olof Hansson, Alicia K. Heath, Ewout J. Hoorn, Hironori Imano, Simerjot K. Jassal, Rudolf Kaaks, Verena Katzke, Jussi Kauhanen, Stefan Kiechl, Wolfgang Koenig, Richard A. Kronmal, Cecilie Kyrø, Deborah A. Lawlor, Börje Ljungberg, Conor MacDonald, Giovanna Masala, Christa Meisinger, Olle Melander, Conchi Moreno Iribas, Toshiharu Ninomiya, Dorothea Nitsch, Børge G. Nordestgaard, Charlotte Onland-Moret, Luigi Palmieri, Dafina Petrova, Jose Ramón Quirós Garcia, Annika Rosengren, Carlotta Sacerdote, Masaru Sakurai, Carmen Santiuste, Matthias B. Schulze, Sabina Sieri, Johan Sundström, Valérie Tikhonoff, Anne Tjønneland, Tammy Tong, Rosario Tumino, Ioanna Tzoulaki, Yvonne T. van der Schouw, W.M. Monique Verschuren, Henry Völzke, Robert B. Wallace, S. Goya Wannamethee, Elisabete Weiderpass, Peter Willeit, Mark Woodward, Kazumasa Yamagishi, Raul Zamora-Ros, Elvis A. Akwo, Saiju Pyarajan, David R. Gagnon, Philip S. Tsao, Sumitra Muralidhar, Todd L. Edwards, Scott M. Damrauer, Jacob Joseph, Lisa Pennells, Peter W.F. Wilson, Seamus Harrison, Thomas A. Gaziano, Michael Inouye, Colin Baigent, Juan P. Casas, Claudia Langenberg, Nick Wareham, Elio Riboli, J.Michael Gaziano, John Danesh, Adriana M. Hung, Adam S. Butterworth, Angela M. Wood, Emanuele Di Angelantonio, Anna Koettgen, Jonathan Shaw, Robert Atkins, Paul Zimmet, Peter Whincup, Johann Willeit, Christoph Leitner, Anne Tybjaerg-Hansen, Peter Schnohr, Shoaib Afzal, David Lora Pablos, Cristina Martin Arriscado, Carmen Romero Ferreiro, Hannah Stocker, Ben Schöttker, Bernd Holleczek, Angela Chetrit, Lennart Welin, Kurt Svärdsudd, Lauren Lissner, Dominique Hange, Kirsten Mehlig, Dorothea Nagel, Paul E. Norman, Osvaldo Almeida, Leon Flicker, Jun Hata, Takanori Honda, Yoshihiko Furuta, Hiroyasu Iso, Akihiko Kitamura, Isao Muraki, Jukka T. Salonen, Tomi-Pekka Tuomainen, E. M. van Zutphen, N. M. van Schoor, Cinzia Lo Noce, Richard Kronmal, Georg Lappas, Peter M. Nilsson, Bo Hedblad, Jonathan Shaffer, Joseph Schwartz, Daichi Shimbo, Shinichi Sato, Mina Hayama-Terada, Simerjot Jassal, Thor Aspelund, Bolli Thorsson, Gunnar Sigurdsson, Layal Chaker, Kamran M. Ikram, Maryam Kavousi, Hugh Tunstall-Pedoe, Günay Can, Hüsniye Yüksel, Uğur Özkan, Hideaki Nakagawa, Yuko Morikawa, Masao Ishizaki, Edith Feskens, Johanna M Geleijnse, Daan Kromhout

Publikováno v: Circulation, 146(20), 1507-1517. Lippincott Williams & Wilkins
Emerging Risk Factors Collaboration/EPIC-CVD/Million Veteran Program 2022, ' Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease : Observational and Mendelian Randomization Analyses ', Circulation, vol. 146, no. 20, pp. 1507-1517 . https://doi.org/10.1161/CIRCULATIONAHA.122.060700
Circulation, 146(20), 1507-1517. Lippincott Williams and Wilkins
Gaziano, L, Sun, L, Arnold, M, Bell, S, Cho, K, Kaptoge, S K, Song, R J, Burgess, S, Posner, D C, Mosconi, K, Robinson-Cohen, C, Mason, A M, Bolton, T R, Tao, R, Allara, E, Schubert, P, Chen, L, Staley, J R, Staplin, N, Altay, S, Amiano, P, Arndt, V, Ärnlöv, J, Barr, E L M, Björkelund, C, Boer, J M A, Brenner, H, Casiglia, E, Chiodini, P, Cooper, J A, Coresh, J, Cushman, M, Dankner, R, Davidson, K W, De Jongh, R T, Donfrancesco, C, Engström, G, Freisling, H, De La Cámara, A G, Gudnason, V, Hankey, G J, Hansson, P O, Heath, A K, Hoorn, E J, Kyrø, C, Nordestgaard, B G, Tjønneland, A, Tybjaerg-Hansen, A, Afzal, S & Emerging Risk Factors Collaboration/EPIC-CVD/Million Veteran Program 2022, ' Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease : Observational and Mendelian Randomization Analyses ', Circulation, vol. 146, no. 20, pp. 1507-1517 . https://doi.org/10.1161/CIRCULATIONAHA.122.060700
Circulation 146, 1507-1517 (2022)

Background: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke. Methods: Observational an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17157dbb2afcb894035ab66f612ff8e
http://hdl.handle.net/2445/192294

Risk factors and prediction models for incident heart failure with reduced and preserved ejection fraction

Autor: Katherine E. Kurgansky, Luc Djoussé, Petra Schubert, John Michael Gaziano, David R. Gagnon, Peter W.F. Wilson, Yuk-Lam Ho, Angela M. Wood, Jacob Joseph, John Danesh, John P. Russo, Ashley Galloway, Liam Gaziano, Emanuele Di Angelantonio, Adam S. Butterworth, Kelly Cho

Publikováno v: ESC Heart Failure
ESC Heart Failure, Vol 8, Iss 6, Pp 4893-4903 (2021)

Aims: This study aims to develop the first race‐specific and sex‐specific risk prediction models for heart failure with preserved (HFpEF) and reduced ejection fraction (HFrEF). Methods and results: We created a cohort of 1.8 million individuals w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c625e6137e4fb49655164eca046281c5
https://doi.org/10.1002/ehf2.13429

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

Autor: Sudha K Iyengar, Yan V. Sun, Stephen Burgess, Nicole M Kosik, Christopher J. O'Donnell, Sonja A. Swanson, Maik Pietzner, Yunling Shi, Kyong-Mi Chang, Alexandre C. Pereira, Philip S. Tsao, Anna Gaulton, A. Patrícia Bento, Jennifer E. Huffman, Juan P Casas, Jin Zhou, Yuk-Lam Ho, Claudia Giambartolomei, Bryan R Gorman, Dennis Valentine, Inigo Barrio-Hernandez, Jing Hua Zhao, Jean C. Beckham, Elias Allara, Daniel C Posner, Kristine E. Lynch, Niklas Hagberg, Christian Lundtoft, David R. Gagnon, Rachel Ramoni, Adriana M. Hung, Lauren O Thomann, Marijana Vujkovic, Lars Rönnblom, Helene Garcon, Praveen Surendran, Liam Gaziano, Bram P. Prins, Poornima Devineni, Scott L. DuVall, Jacob Joseph, Grant D. Huang, John Danesh, Andrew R. Leach, James E. Peters, Todd L. Edwards, J. Michael Gaziano, Kelly Cho, Pedro Beltrao, Claudia Langenberg, Sumitra Muralidhar, Adam S. Butterworth, Saiju Pyarajan

Drug repurposing provides a rapid approach to meet the urgent need for therapeutics to address COVID-19. To identify therapeutic targets relevant to COVID-19, we conducted Mendelian randomization (MR) analyses, deriving genetic instruments based on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1da248fa154d58173fd385b706c52a1f
https://doi.org/10.1101/2020.11.19.20234120