Mitochondrial Proteome Changes in Rett Syndrome

Autor: Gocha Golubiani, Laura van Agen, Lia Tsverava, Revaz Solomonia, Michael Müller

Publikováno v: Biology, Vol 12, Iss 7, p 956 (2023)

Rett syndrome (RTT) is a genetic neurodevelopmental disorder with mutations in the X-chromosomal MECP2 (methyl-CpG-binding protein 2) gene. Most patients are young girls. For 7–18 months after birth, they hardly present any symptoms; later they dev

Externí odkaz: https://doaj.org/article/a51227f06c75433da5b605d5480ec8ed

Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats

Autor: Manana Kandashvili, Georgi Gamkrelidze, Lia Tsverava, Tamar Lordkipanidze, Eka Lepsveridze, Vincenzo Lagani, Maia Burjanadze, Manana Dashniani, Merab Kokaia, Revaz Solomonia

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 1198, p 1198 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1198

Epilepsy is a severe neurological disease characterized by spontaneous recurrent seizures (SRS). A complex pathophysiological process referred to as epileptogenesis transforms a normal brain into an epileptic one. Prevention of epileptogenesis is a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa60c6e5849b8e81d6974d0abb0ef2cb
https://www.mdpi.com/1422-0067/23/3/1198

Age-related changes in medial septal cholinergic and GABAergic projection neurons and hippocampal neurotransmitter receptors: relationship with memory impairment

Autor: Maia A, Burjanadze, Manana G, Dashniani, Revaz O, Solomonia, Gela V, Beselia, Lia, Tsverava, Vincenzo, Lagani, Nino C, Chkhikvishvili, Temur L, Naneishvili, Lali B, Kruashvili, Mariam R, Chighladze

Publikováno v: Experimental brain research. 240(5)

The hippocampus, which provides cognitive functions, has been shown to become highly vulnerable during aging. One important modulator of the hippocampal neural network is the medial septum (MS). The present study attempts to determine how age-related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2428d4c9e0f0d07ee3c508f89b788cda
https://pubmed.ncbi.nlm.nih.gov/35357523

Antibody profiling reveals gender differences in response to SARS-COVID-2 infection

Autor: Gvantsa Chanturia, Revaz Solomonia, Lia Tsverava, Merab Kekelidze, Nazibrola Chitadze, Paata Imnadze, David Dzneladze, Amiran Gamkrelidze, Zaza Khuchua, Vincenzo Lagani

The recent emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an ongoing global COVID-19 pandemic and public health crisis. Detailed study of human immune response to SARS-COVIS-2 infection is the important

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::188c69a5f1fd25cef76ab50316fdcc7a
https://doi.org/10.1101/2021.06.01.21258175

Myoinositol Attenuates the Cell Loss and Biochemical Changes Induced by Kainic Acid Status Epilepticus

Autor: Lia Tsverava, Tamar Lordkipanidze, Revaz Solomonia, Marina Kikvidze, Maia Nozadze, Eka Lepsveridze

Publikováno v: BioMed Research International, Vol 2016 (2016)
BioMed Research International

Identification of compounds preventing or modifying the biochemical changes that underlie the epileptogenesis process and understanding the mechanism of their action are of great importance. We have previously shown that myoinositol (MI) daily treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c9dc2cb2a86d19efeff5c0a36c015a3
https://doaj.org/article/5db52f6a62fa44448e6939c7c4758f06