Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lia Tescione"'
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 117(6)
There are three main potential sources for cell shear damage existing in stirred tank bioreactors. One is the potential high energy dissipation in the immediate impeller zones; another from small gas bubble burst; and third is from high gas entrance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5dc7999c7bcce950c07f3b221202e5a
https://pubmed.ncbi.nlm.nih.gov/32086806
https://pubmed.ncbi.nlm.nih.gov/32086806
Autor:
Lam Raga Anggara Markely, Lila Cheung, Young Jun Choi, Thomas Ryll, Scott Estes, Shashi Prajapati, Iva Turyan, Ruth Frenkel, Zoran Sosic, James Lambropoulos, Lia Tescione, Melissa Berman
Publikováno v:
Biotechnology Progress. 32:235-241
The serum half-life, biological activity, and solubility of many recombinant glycoproteins depend on their sialylation. Monitoring glycoprotein sialylation during cell culture manufacturing is, therefore, critical to ensure product efficacy and safet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e7c34931861fd97ec8d28366fdb2d3
https://doi.org/10.1002/btpr.2206
https://doi.org/10.1002/btpr.2206
Publikováno v:
Biotechnology and Bioengineering. 112:84-97
A bench scale cell culture model representative of manufacturing scale (2,000 L) was developed based on oxygen mass transfer principles, for a CHO-based process producing a recombinant human protein. Cell culture performance differences across scales
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9d481eafcda3fc6d2c26464ac59eed1
https://doi.org/10.1002/bit.25330
https://doi.org/10.1002/bit.25330
Autor:
Lia, Tescione, James, Lambropoulos, Madhava Ram, Paranandi, Helena, Makagiansar, Thomas, Ryll
Publikováno v:
Biotechnology and bioengineering. 112(1)
A bench scale cell culture model representative of manufacturing scale (2,000 L) was developed based on oxygen mass transfer principles, for a CHO-based process producing a recombinant human protein. Cell culture performance differences across scales
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b72aa69cbfbefb406114f4fbf6c2c7f5
https://pubmed.ncbi.nlm.nih.gov/25042258
https://pubmed.ncbi.nlm.nih.gov/25042258
Autor:
Lia Tescione, Diana Cheung, Javier Femenia, Isabelle Nadeau, Jim Michaels, Stephen F. Gorfien, Delia Fernandez, Bryan Monroe
Publikováno v:
Animal Cell Technology: Basic & Applied Aspects ISBN: 9781402096457
The complexity and expense associated with large-scale perfusion culture systems make them impractical for medium optimization studies involving DOE approaches. We have employed scale-down processes involving shake flask cultures seeded at high den
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2ec22b33a27afa3a5be29beada7ff35
https://doi.org/10.1007/978-1-4020-9646-4_10
https://doi.org/10.1007/978-1-4020-9646-4_10
Publikováno v:
Cell Technology for Cell Products ISBN: 9781402054754
rNS0 cell line has been grown in protein-free, chemically-defined medium using stirred-tank bioreactors in batch and fed-batch mode. Various operating parameters, including pH and temperature, were investigated to assess their effect on growth and Ig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff30883f2a8338bd6f08154464880b40
https://doi.org/10.1007/978-1-4020-5476-1_124
https://doi.org/10.1007/978-1-4020-5476-1_124
Autor:
Dale F. Gruber, Donald Munroe, Lia Tescione, Scott J. Jacobia, Robert W. Kenerson, David W. Jayme, Stephen F. Gorfien
Publikováno v:
Animal Cell Technology: Basic & Applied Aspects ISBN: 9781402043123
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68e72228235c30568552c6691dbe76ef
https://doi.org/10.1007/1-4020-4457-7_27
https://doi.org/10.1007/1-4020-4457-7_27
Publikováno v:
ESACT Proceedings ISBN: 1402027915
Growth of NS0 cells in a protein-free, chemically defined culture system has been made possible by the development of cyclodextrin-based lipid additives. Batch cultures of NS0 cells in this system demonstrated growth and expression levels equal to or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ad16192c76cfefc50a7e45f1fbf398b
https://doi.org/10.1007/1-4020-3103-3_146
https://doi.org/10.1007/1-4020-3103-3_146