Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Lia Luus"'
Autor:
Walid Kamoun, Elden Swindell, Christine Pien, Lia Luus, Jason Cain, Minh Pham, Irawati Kandela, Zhaohua Richard Huang, Suresh K. Tipparaju, Alexander Koshkaryev, Vasileios Askoxylakis, Dmitri B. Kirpotin, Troy Bloom, Mari Mino-Kenudson, James D. Marks, Alena Zalutskaya, Wiam Bshara, Carl Morrison, Daryl C. Drummond
Publikováno v:
Pharmaceutics, Vol 12, Iss 10, p 996 (2020)
Ephrin receptor A2 (EphA2) is a member of the Ephrin/Eph receptor cell-to-cell signaling family of molecules, and it plays a key role in cell proliferation, differentiation, and migration. EphA2 is overexpressed in a broad range of cancers, and its e
Externí odkaz:
https://doaj.org/article/8d1191f930f84ed890aae26feb4148ee
Autor:
Magali Guffroy, Bruce Trela, Takahito Kambara, Lukasz Stawski, Huidong Chen, Lia Luus, Monica S Montesinos, Lauren Olson, Yupeng He, Kevin Maisonave, Tracy Carr, Min Lu, Adrian S Ray, Lisa A Hazelwood
Publikováno v:
Toxicological Sciences. 191:400-413
Administration of a novel and selective small molecule integrin αvβ6 inhibitor, MORF-627, to young cynomolgus monkeys for 28 days resulted in the rapid induction of epithelial proliferative changes in the urinary bladder of 2 animals, in the absenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a953ca2accf887bc47562b923447851
https://doi.org/10.1093/toxsci/kfac128
https://doi.org/10.1093/toxsci/kfac128
Autor:
Andrew J. Sawyer, Daryl C. Drummond, Zhaohua Richard Huang, Eric Tam, Vasileios Askoxylakis, Gang Sun, Alexander Koshkaryev, Michael Santiago, Lia Luus, James F. Sampson, Ross B. Fulton, Stephanie Grabow, James J. Suchy, Anne-Sophie Dugast, Walid S. Kamoun
Supplemental figures 1, 2, and 3 and supplemental tables 1 and 2, showing the antitumor activity of EphA2-ILS-DTXp and the pharmacokinetics in multiple murine tumor models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc53494c662779c87e655ae0c6423c80
https://doi.org/10.1158/1535-7163.22509429
https://doi.org/10.1158/1535-7163.22509429
Autor:
Ulrik B. Nielsen, Birgit Schoeberl, Arthur J. Kudla, Michael J. Feldhaus, Matt Wallace, Neeraj Kohli, Jinming Gu, Stephanie Nguyen, Ryan Overland, Lia Luus, Bo Zhang, Shinji Oyama, Violette Paragas, Sharlene Adams, Brian D. Harms, Alexandra Huhalov, Charlotte F. McDonagh
PDF file - 189K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740c3b57b3148fec19b2a1932a1c942b
https://doi.org/10.1158/1535-7163.22498605
https://doi.org/10.1158/1535-7163.22498605
Autor:
Andrew J. Sawyer, Daryl C. Drummond, Zhaohua Richard Huang, Eric Tam, Vasileios Askoxylakis, Gang Sun, Alexander Koshkaryev, Michael Santiago, Lia Luus, James F. Sampson, Ross B. Fulton, Stephanie Grabow, James J. Suchy, Anne-Sophie Dugast, Walid S. Kamoun
Combinations of chemotherapy with immunotherapy have seen recent clinical success, including two approvals of anti–PD-1/L1 agents in combination with taxane-based chemotherapy in non–small cell lung cancer and triple-negative breast cancer. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb2072df5200a5c5f8144cbc7a5091df
https://doi.org/10.1158/1535-7163.c.6539295.v1
https://doi.org/10.1158/1535-7163.c.6539295.v1
Autor:
Natalia Reszka-Blanco, Megan Krumpoch, Huidong Chen, Lia Luus, Michaela Mentzer, Aleksey Molodtsov, Adrian Ray, Vinod Yadav, Matthew Clark, Ian Gerken, Justin Snider, Blaise Lippa, Bruce Rogers, Gerard Bain
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a47b68cabb0ef7eaf23ab2b21ddbebe
https://doi.org/10.1136/jitc-2022-sitc2022.0834
https://doi.org/10.1136/jitc-2022-sitc2022.0834
Autor:
Kristen Hurov, Lia Luus, Johanna Lahdenranta, Punit Upadhyaya, Heather Cohen, Chinmayee Shah, Julia Kristensson, Peter Brown, Gemma Mudd, Carly Campbell, Elizabeth Repash, Eric Haines, Sailaja Battula, Mike Kelly, Phil Jeffrey, Paul Beswick, Liuhong Chen, Kevin McDonnell, Philip Brandish, Nicholas Keen
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f969126e40fad5d1270f04621dffbb4
https://doi.org/10.1136/jitc-2022-sitc2022.1340
https://doi.org/10.1136/jitc-2022-sitc2022.1340
Autor:
Punit Upadhyaya, Julia Kristensson, Johanna Lahdenranta, Elizabeth Repash, Jun Ma, Jessica Kublin, Gemma E. Mudd, Lia Luus, Phil Jeffrey, Kristen Hurov, Kevin McDonnell, Nicholas Keen
Publikováno v:
Journal of medicinal chemistry. 65(14)
CD137 (4-1BB) is a co-stimulatory receptor on immune cells and Nectin-4 is a cell adhesion molecule that is overexpressed in multiple tumor types. Using a series of poly(ethylene glycol) (PEG)-based linkers, synthetic bicyclic peptides targeting CD13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c27610ba02170186a7dd0cfd287a4aa
https://pubmed.ncbi.nlm.nih.gov/35819182
https://pubmed.ncbi.nlm.nih.gov/35819182
Autor:
Lia Luus, Kristen Hurov, Johanna Lahdenranta, Chinmayee Shah, Anna Devlen, Julia Kristensson, Peter Brown, Cara Bray, Heather Cohen, Carly Campbell, Gemma Mudd, Punit Upadhyaya, Kevin McDonnell, Hongmei Xu, Phil Jeffrey, Philip E. Brandish, Nicholas Keen
Publikováno v:
Cancer Research. 83:1832-1832
We have developed a new class of modular synthetic drugs, termed Bicycle® tumor-targeted immune cell agonists (Bicycle® TICAs), which are multi-specific molecules composed of constrained bicyclic peptides (Bicycles)1. The first molecule of this cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46754c475147f5c4c10bcd415df05928
https://doi.org/10.1158/1538-7445.am2023-1832
https://doi.org/10.1158/1538-7445.am2023-1832
Autor:
Alexander Koshkaryev, Walid S. Kamoun, Gang Sun, Vasileios Askoxylakis, Lia Luus, Ross B. Fulton, James F. Sampson, Eric M. Tam, Andrew J. Sawyer, Zhaohua Richard Huang, Daryl C. Drummond, Anne-Sophie Dugast, Michael Santiago, James Suchy, Stephanie Grabow
Publikováno v:
Molecular Cancer Therapeutics. 19:270-281
Combinations of chemotherapy with immunotherapy have seen recent clinical success, including two approvals of anti–PD-1/L1 agents in combination with taxane-based chemotherapy in non–small cell lung cancer and triple-negative breast cancer. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d1de2be371c87bef464a4ffd8c4529
https://doi.org/10.1158/1535-7163.mct-19-0414
https://doi.org/10.1158/1535-7163.mct-19-0414