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Publikováno v:
Progress in Lipid Research. 72:55-74
The reaction specificity of lipoxygenases (ALOX) impacts the biological activity of these enzymes and also constitutes the decisive parameter for enzyme classification. ALOX15 orthologs, commonly known as 12/15-lipoxygenases, have recently been sugge
Autor:
Dagmar Heydeck, Hartmut Kühn, Sabine Stehling, Lia Humeniuk, Christoph Ufer, Alexey Golovanov, Nikita Kozlov, Igor Ivanov
Publikováno v:
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1864(3)
Arachidonic acid lipoxygenases (ALOXs) are lipid-metabolizing enzymes that have been implicated in cell differentiation, but also in the pathogenesis of inflammatory, hyperproliferative and neurological diseases. Most mammalian genomes involve six or