Zobrazeno 1 - 10
of 22
pro vyhledávání: '"LiKang Chin"'
Autor:
Emily L. Rudolph, LiKang Chin
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 7, Pp 7134-7146 (2024)
With the ongoing obesity epidemic, the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is expected to rise and necessitates a greater understanding of how the disease proceeds from benign excess lipid in hepatocytes to
Externí odkaz:
https://doaj.org/article/350c11dc060541d6a734dcdbe593f071
Publikováno v:
Biology, Vol 13, Iss 6, p 434 (2024)
The growing obesity epidemic necessitates increased research on adipocyte and adipose tissue function and disease mechanisms that progress obesity. Historically, adipocytes were viewed simply as storage for excess energy. However, recent studies have
Externí odkaz:
https://doaj.org/article/40fface4c3954b57bd8184d2c652c9ab
Autor:
Maryna Perepelyuk, LiKang Chin, Xuan Cao, Anne van Oosten, Vivek B Shenoy, Paul A Janmey, Rebecca G Wells
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146588 (2016)
Tissues including liver stiffen and acquire more extracellular matrix with fibrosis. The relationship between matrix content and stiffness, however, is non-linear, and stiffness is only one component of tissue mechanics. The mechanical response of ti
Externí odkaz:
https://doaj.org/article/47e36e5b3c6f44fba5bda7cd6eeefbcf
Autor:
Katarzyna Pogoda, LiKang Chin, Penelope C Georges, FitzRoy J Byfield, Robert Bucki, Richard Kim, Michael Weaver, Rebecca G Wells, Cezary Marcinkiewicz, Paul A Janmey
Publikováno v:
New Journal of Physics, Vol 16, Iss 7, p 075002 (2014)
Many cell types, including neurons, astrocytes and other cells of the central nervous system, respond to changes in the extracellular matrix or substrate viscoelasticity, and increased tissue stiffness is a hallmark of several disease states, includi
Externí odkaz:
https://doaj.org/article/4d26c306e56842cbb0f8a3d39587ca0d
Autor:
Bin Wu, Di-Ao Liu, Lei Guan, Phyoe Kyawe Myint, LiKang Chin, Hien Dang, Ye Xu, Jinqi Ren, Ting Li, Ziyan Yu, Sophie Jabban, Gordon B. Mills, Jonathan Nukpezah, Youhai H. Chen, Emma E. Furth, Phyllis A. Gimotty, Rebecca G. Wells, Valerie M. Weaver, Ravi Radhakrishnan, Xin Wei Wang, Wei Guo
Publikováno v:
Nature Cell Biology. 25:415-424
Autor:
Dawid Łysik, Piotr Deptuła, Sylwia Chmielewska, Karol Skłodowski, Katarzyna Pogoda, LiKang Chin, Dawei Song, Joanna Mystkowska, Paul A. Janmey, Robert Bucki
Publikováno v:
ACS biomaterials scienceengineering. 8(11)
Deoxyribonucleic acid (DNA) evolved as a tool for storing and transmitting genetic information within cells, but outside the cell, DNA can also serve as "construction material" present in microbial biofilms or various body fluids, such as cystic fibr
Autor:
Nicholas Arpaia, Florian Hamberger, Raghu Kalluri, Ekihiro Seki, Thomas Savage, Di Zhu, Likang Chin, Ingmar Mederacke, Ajay Nair, Rebecca G. Wells, Maximilian Miller, Naita Maren Wirsik, Silvia Affò, Robert F. Schwabe, Aveline Filliol, Thomas Schmidt, Ben Z. Stanger, Matthias Mack, Kenneth P. Olive, Aashreya Ravichandra, Sonakshi Bhattacharjee, Peter A. Sims, Adam Mehal, Deqi Yin
Publikováno v:
J Clin Invest
The Journal of clinical investigation, vol 131, iss 11
The Journal of clinical investigation, vol 131, iss 11
Cancer-associated fibroblasts (CAF) may exert tumor-promoting and tumor-suppressive functions, but the mechanisms underlying these opposing effects remain elusive. Here, we sought to understand these potentially opposing functions by interrogating fu
Autor:
Aveline Filliol, Yoshinobu Saito, Ajay Nair, Dianne H. Dapito, Le-Xing Yu, Aashreya Ravichandra, Sonakshi Bhattacharjee, Silvia Affo, Naoto Fujiwara, Hua Su, Qiuyan Sun, Thomas M. Savage, John R. Wilson-Kanamori, Jorge M. Caviglia, LiKang Chin, Dongning Chen, Xiaobo Wang, Stefano Caruso, Jin Ku Kang, Amit Dipak Amin, Sebastian Wallace, Ross Dobie, Deqi Yin, Oscar M. Rodriguez-Fiallos, Chuan Yin, Adam Mehal, Benjamin Izar, Richard A. Friedman, Rebecca G. Wells, Utpal B. Pajvani, Yujin Hoshida, Helen E. Remotti, Nicholas Arpaia, Jessica Zucman-Rossi, Michael Karin, Neil C. Henderson, Ira Tabas, Robert F. Schwabe
Publikováno v:
Nature
Hepatocellular carcinoma (HCC), the fourth leading cause of cancer mortality, develops almost exclusively in patients with chronic liver disease (CLD) and advanced fibrosis(1,2). Here we interrogated functions of hepatic stellate cells (HSC), the mai
Autor:
Paul A. Janmey, Katarzyna Pogoda, Xingyu Chen, Alison E. Patteson, Katrina Cruz, Vivek B. Shenoy, Anne van Oosten, Likang Chin
Publikováno v:
Nature. 573:96-101
The viscoelasticity of the crosslinked semiflexible polymer networks—such as the internal cytoskeleton and the extracellular matrix—that provide shape and mechanical resistance against deformation is assumed to dominate tissue mechanics. However,
Autor:
Silvia Affò, Aashreya Ravichandra, Francesco Brundu, Aveline Filliol, LiKang Chin, Wen Wen, Deqi Yin, Sonakshi Bhattacharjee, Raul Rabadan, Raghu Kalluri, Lars Zender, Rebecca Wells, Xin Chen, Robert F. Schwabe
Publikováno v:
Journal of Hepatology. 73:S17-S18