Výsledky vyhledávání

Akademický článek

Predictive value of early amplitude integrated electroencephalogram (aEEG) in sleep related problems in children with perinatal hypoxic-ischemia (HIE)

Autor: Qiuyan Tian, Yizhi Pan, Zheng Zhang, Mei Li, Li-xiao Xu, Min Gong, Po Miao, Xiaolu Jiang, Xiaofeng Yang, Chen-Xi Feng, Jian Pan, Yun Yu, Bin Sun, Xin Ding

Publikováno v: BMC Pediatrics, Vol 21, Iss 1, Pp 1-7 (2021)

Abstract Background While great attention has been paid to motor and cognitive impairments in children with neonatal Hypoxic-Ischemic Encephalopathy (HIE), sleep related circadian rhythm problems, although commonly present, are often neglected. Subse

Externí odkaz: https://doaj.org/article/f712f0a2c4934ce588e24f84316cf3ef

Zobrazit plný text záznamu

Akademický článek

TP53-induced glycolysis and apoptosis regulator alleviates hypoxia/ischemia-induced microglial pyroptosis and ischemic brain damage

Autor: Lan-Lan Tan, Xiao-Lu Jiang, Li-Xiao Xu, Gen Li, Chen-Xi Feng, Xin Ding, Bin Sun, Zheng-Hong Qin, Zu-Bin Zhang, Xing Feng, Mei Li

Publikováno v: Neural Regeneration Research, Vol 16, Iss 6, Pp 1037-1043 (2021)

Our previous studies have demonstrated that TP53-induced glycolysis and apoptosis regulator (TIGAR) can protect neurons after cerebral ischemia/reperfusion. However, the role of TIGAR in neonatal hypoxic-ischemic brain damage (HIBD) remains unknown.

Externí odkaz: https://doaj.org/article/5d17489d68fc4386aa1d3ff10a79b467

Zobrazit plný text záznamu

Akademický článek

The role of pineal microRNA-325 in regulating circadian rhythms after neonatal hypoxic-ischemic brain damage

Autor: Ning Sha, Hua-Wei Wang, Bin Sun, Min Gong, Po Miao, Xiao-Lu Jiang, Xiao-Feng Yang, Mei Li, Li-Xiao Xu, Chen-Xi Feng, Yuan-Yuan Yang, Jie Zhang, Wen-Jing Zhu, Yuan-Yuan Gao, Xing Feng, Xin Ding

Publikováno v: Neural Regeneration Research, Vol 16, Iss 10, Pp 2071-2077 (2021)

Circadian rhythm disorder is a common, but often neglected, consequence of neonatal hypoxic-ischemic brain damage (HIBD). However, the underlying molecular mechanisms remain largely unknown. We previously showed that, in a rat model of HIBD, up-regul

Externí odkaz: https://doaj.org/article/83ab8ac6e48f4849a7b56f7904d693e2

Zobrazit plný text záznamu

Akademický článek

Profiling Temporal Changes of the Pineal Transcriptomes at Single Cell Level Upon Neonatal HIBD

Autor: Xin Ding, Tao Pan, Qiuyan Tian, Wenxi Huang, Lauren S Hayashi, Qin Liu, Fuyong Li, Li-Xiao Xu, Po Miao, Xiaofeng Yang, Bin Sun, Chen-Xi Feng, Xing Feng, Mei Li, Jian Huang

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Neonatal hypoxic-ischemic brain damage (HIBD) often results in various neurological deficits. Among them, a common, yet often neglected, symptom is circadian rhythm disorders. Previous studies revealed that the occurrence of cysts in the pineal gland

Externí odkaz: https://doaj.org/article/a07e47c403e64976a21259c66217963e

Zobrazit plný text záznamu

Akademický článek

Knocking down TRPM2 expression reduces cell injury and NLRP3 inflammasome activation in PC12 cells subjected to oxygen-glucose deprivation

Autor: Tao Pan, Qiu-Jiao Zhu, Li-Xiao Xu, Xin Ding, Jian-Qin Li, Bin Sun, Jun Hua, Xing Feng

Publikováno v: Neural Regeneration Research, Vol 15, Iss 11, Pp 2154-2161 (2020)

Transient receptor potential melastatin 2 (TRPM2) is an important ion channel that represents a potential target for treating injury caused by cerebral ischemia. However, it is unclear whether reducing TRPM2 expression can help repair cerebral injury

Externí odkaz: https://doaj.org/article/4ad8c07af5914c60b8c7308537daf599

Zobrazit plný text záznamu

Akademický článek

Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins

Autor: Li-Xiao Xu, Yuan Lv, Yan-Hong Li, Xin Ding, Ying Wang, Xing Han, Ming-Hua Liu, Bin Sun, Xing Feng

Publikováno v: BMC Pediatrics, Vol 17, Iss 1, Pp 1-13 (2017)

Abstract Background Previous studies have indicated edema may be involved in the pathophysiology following hypoxic-ischemic encephalopathy (HIE), and melatonin may exhibit neuro-protection against brain insults. However, little is known regarding the

Externí odkaz: https://doaj.org/article/0978a36d66a742d09cdac8918dc501c7

Zobrazit plný text záznamu

Akademický článek

Neuroprotective effects of autophagy inhibition on hippocampal glutamate receptor subunits after hypoxia-ischemia-induced brain damage in newborn rats

Autor: Li-xiao Xu, Xiao-juan Tang, Yuan-yuan Yang, Mei Li, Mei-fang Jin, Po Miao, Xin Ding, Ying Wang, Yan-hong Li, Bin Sun, Xing Feng

Publikováno v: Neural Regeneration Research, Vol 12, Iss 3, Pp 417-424 (2017)

Autophagy has been suggested to participate in the pathology of hypoxic-ischemic brain damage (HIBD). However, its regulatory role in HIBD remains unclear and was thus examined here using a rat model. To induce HIBD, the left common carotid artery wa

Externí odkaz: https://doaj.org/article/609d9760bac24d038f51f7470d427547

Zobrazit plný text záznamu

Akademický článek

Molecular Targeting of the Oncoprotein PLK1 in Pediatric Acute Myeloid Leukemia: RO3280, a Novel PLK1 Inhibitor, Induces Apoptosis in Leukemia Cells

Publikováno v: International Journal of Molecular Sciences, Vol 16, Iss 1, Pp 1266-1292 (2015)

Polo-like kinase 1 (PLK1) is highly expressed in many cancers and therefore a biomarker of transformation and potential target for the development of cancer-specific small molecule drugs. RO3280 was recently identified as a novel PLK1 inhibitor; howe

Externí odkaz: https://doaj.org/article/734192c36d9241a2821a94c5fc240ac6

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Vyhledávací nástroje:

Upřesnit hledání