Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Li-nan CHEN"'
Autor:
Xiangyu Ma, Li-Nan Chen, Menghui Liao, Liyan Zhang, Kun Xi, Jiamin Guo, Cangsong Shen, Dan-Dan Shen, Pengjun Cai, Qingya Shen, Jieyu Qi, Huibing Zhang, Shao-Kun Zang, Ying-Jun Dong, Luwei Miao, Jiao Qin, Su-Yu Ji, Yue Li, Jianfeng Liu, Chunyou Mao, Yan Zhang, Renjie Chai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The class C orphan G-protein-coupled receptor (GPCR) GPR156, which lacks the large extracellular region, plays a pivotal role in auditory function through Gi2/3. Here, we firstly demonstrate that GPR156 with high constitutive activity is ess
Externí odkaz:
https://doaj.org/article/eda175ba92a2443a9b31648e453755f1
Autor:
Chunyou Mao, Mengru Gao, Shao-Kun Zang, Yanqing Zhu, Dan-Dan Shen, Li-Nan Chen, Liu Yang, Zhiwei Wang, Huibing Zhang, Wei-Wei Wang, Qingya Shen, Yanhui Lu, Xin Ma, Yan Zhang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Hydroxycarboxylic acids are crucial metabolic intermediates involved in various physiological and pathological processes, some of which are recognized by specific hydroxycarboxylic acid receptors (HCARs). HCAR2 is one such receptor, activate
Externí odkaz:
https://doaj.org/article/3d12386a7f56474cb3159fa3507635cb
Autor:
Su-Yu Ji, Ying-Jun Dong, Li-Nan Chen, Shao-Kun Zang, Jiawei Wang, Dan-Dan Shen, Jia Guo, Jiao Qin, Huibing Zhang, Wei-Wei Wang, Qingya Shen, Yan Zhang, Zhangfa Song, Chunyou Mao
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/a7fc1e0cc4d14a0da525d817e3d4874d
Autor:
Yu Ding, Huibing Zhang, Yu-Ying Liao, Li-Nan Chen, Su-Yu Ji, Jiao Qin, Chunyou Mao, Dan-Dan Shen, Lin Lin, Hao Wang, Yan Zhang, Xiao-Ming Li
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-16 (2022)
Abstract The intestinal hormone and neuromodulator cholecystokinin (CCK) receptors CCK1R and CCK2R act as a signaling hub in brain–gut axis, mediating digestion, emotion, and memory regulation. CCK receptors exhibit distinct preferences for ligands
Externí odkaz:
https://doaj.org/article/e285608cbc6e41eab15696ca955bdfa1
Autor:
Zhehua Shao, Yangxia Tan, Qingya Shen, Li Hou, Bingpeng Yao, Jiao Qin, Peiyu Xu, Chunyou Mao, Li-Nan Chen, Huibing Zhang, Dan-Dan Shen, Chao Zhang, Weijie Li, Xufei Du, Fei Li, Zhi-Hua Chen, Yi Jiang, H. Eric Xu, Songmin Ying, Honglei Ma, Yan Zhang, Huahao Shen
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures of two human CC chemokine receptor–G-protein complexes:
Externí odkaz:
https://doaj.org/article/ddfaf8d72624436ea3ba8d6100f0cbf8
Autor:
Jia Duan, Dan-Dan Shen, Tingting Zhao, Shimeng Guo, Xinheng He, Wanchao Yin, Peiyu Xu, Yujie Ji, Li-Nan Chen, Jinyu Liu, Huibing Zhang, Qiufeng Liu, Yi Shi, Xi Cheng, Hualiang Jiang, H. Eric Xu, Yan Zhang, Xin Xie, Yi Jiang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The basis for the diverse peptide-binding modes and the G protein selectivity of peptide GPCRs remains elusive. Here, the authors offer a structural basis for allosteric-like agonism and G protein selectivity of a neuropeptide GPCR, galanin receptor.
Externí odkaz:
https://doaj.org/article/c377c461f78f4f958ab7e0da1b397e3e
Autor:
Fenghui Zhao, Qingtong Zhou, Zhaotong Cong, Kaini Hang, Xinyu Zou, Chao Zhang, Yan Chen, Antao Dai, Anyi Liang, Qianqian Ming, Mu Wang, Li-Nan Chen, Peiyu Xu, Rulve Chang, Wenbo Feng, Tian Xia, Yan Zhang, Beili Wu, Dehua Yang, Lihua Zhao, H. Eric Xu, Ming-Wei Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Multi-targeting agonists at GIPR, GLP-1R or GCGR are pursued vigorously. Here, the authors report cryo-EM structures of tirzepatide-bound GIPR and GLP-1R, peptide 20-bound GIPR, GLP-1R and GCGR, revealing the molecular basis of their multiplexed phar
Externí odkaz:
https://doaj.org/article/641f94f40fa443e4a6c8bf6fd15fb04c
Autor:
Zhaotong Cong, Li-Nan Chen, Honglei Ma, Qingtong Zhou, Xinyu Zou, Chenyu Ye, Antao Dai, Qing Liu, Wei Huang, Xianqiang Sun, Xi Wang, Peiyu Xu, Lihua Zhao, Tian Xia, Wenge Zhong, Dehua Yang, H. Eric Xu, Yan Zhang, Ming-Wei Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The glucagon-like peptide-1 (GLP-1) receptor is a key regulator of glucose homeostasis and a drug target for type 2 diabetes but available GLP-1R agonists are suboptimal due to several side-effects. Here authors report the cryo-EM structure of GLP-1R
Externí odkaz:
https://doaj.org/article/092caffa900241a1b25c21698353ff0d
Publikováno v:
Tongxin xuebao, Vol 35, Pp 72-75 (2014)
To make KVM virtual machine which have been created in CloudStack platform identified and taken over correctly in CloudStack and OpenStack concomitant environment,propose a method for live migration of KVM virtual machine from CloudStack to OpenStack
Externí odkaz:
https://doaj.org/article/2a72f15783464806a2975d719ae7e16d
Publikováno v:
Tongxin xuebao, Vol 35, Pp 58-64 (2014)
Packet classification algorithms based on decision tree are easy to implement and widely employed in high-speed packet classification.The primary objective of constructing a decision tree is minimal storage and searching time complexity.An improved d
Externí odkaz:
https://doaj.org/article/90bdb684205144229bf5facab8a4f55b